Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Haruhide Kimura"'
Autor:
Kayo Mitsukawa, Michiko Terada, Ryuji Yamada, Taku Monjo, Tetsuaki Hiyoshi, Masanori Nakakariya, Yuichi Kajita, Tatsuya Ando, Tatsuki Koike, Haruhide Kimura
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Narcolepsy type 1 (NT1) is associated with severe loss of orexin neurons and characterized by symptoms including excessive daytime sleepiness and cataplexy. Current medications indicated for NT1 often show limited efficacy, not addressing th
Externí odkaz:
https://doaj.org/article/ac674994309446aba1e2b02d95031521
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Pathological proteins including tau are produced in neurons and released into interstitial fluid (ISF) in a neural activity-dependent manner during wakefulness. Pathological proteins in ISF can be removed from the brain via the glymphatic pa
Externí odkaz:
https://doaj.org/article/3809d99f56e04798901753c69e5f1c61
Publikováno v:
PLoS ONE, Vol 19, Iss 6, p e0306099 (2024)
Orexin-mediated stimulation of orexin receptors 1/2 (OX[1/2]R) may stimulate the diaphragm and genioglossus muscle via activation of inspiratory neurons in the pre-Bötzinger complex, which are critical for the generation of inspiratory rhythm, and p
Externí odkaz:
https://doaj.org/article/1fed6030e2c04f08a5ec9e47f86bf5d5
Autor:
Kayo Mitsukawa, Haruhide Kimura
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Orexin, a neuropeptide, performs various physiological functions, including the regulation of emotion, feeding, metabolism, respiration, and sleep/wakefulness, by activating the orexin 1 receptor and orexin 2 receptor (OX2R). Owing to the pi
Externí odkaz:
https://doaj.org/article/9b7eaf353abc4ad29d16bc55e8b73715
Autor:
Atsushi Suzuki, Akiyoshi Kunugi, Yasukazu Tajima, Noriko Suzuki, Motohisa Suzuki, Masashi Toyofuku, Haruhiko Kuno, Satoshi Sogabe, Yohei Kosugi, Yasuyuki Awasaki, Tomohiro Kaku, Haruhide Kimura
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Agonistic profiles of AMPA receptor (AMPA-R) potentiators may be associated with seizure risk and bell-shaped dose-response effects. Here, we report the pharmacological characteristics of a novel AMPA-R potentiator, TAK-653, which exhibits m
Externí odkaz:
https://doaj.org/article/0d63b239f564462aba95ccd87d503257
Autor:
Li Zhang, Genay Pilarowski, Emilio Merlo Pich, Atsushi Nakatani, John Dunlop, Rina Baba, Satoru Matsuda, Masaki Daini, Yasushi Hattori, Shigemitsu Matsumoto, Mitsuhiro Ito, Haruhide Kimura, Hans Tomas Bjornsson
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss , Pp 779-791 (2021)
Kabuki syndrome (KS) is a rare cause of intellectual disability primarily caused by loss-of-function mutations in lysine-specific methyltransferase 2D (KMT2D), which normally adds methyl marks to lysine 4 on histone 3. Previous studies have shown tha
Externí odkaz:
https://doaj.org/article/6bb431629e2043e29d57edb98e0cfd0f
Autor:
Atsushi Suzuki, Akiyoshi Kunugi, Yasukazu Tajima, Noriko Suzuki, Motohisa Suzuki, Masashi Toyofuku, Haruhiko Kuno, Satoshi Sogabe, Yohei Kosugi, Yasuyuki Awasaki, Tomohiro Kaku, Haruhide Kimura
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-3 (2021)
Externí odkaz:
https://doaj.org/article/8ad097acaf434529807db669202d1f2f
Autor:
Takao Mandai, Yuu Sako, Emi Kurimoto, Yuji Shimizu, Minoru Nakamura, Makoto Fushimi, Ryouta Maeda, Maki Miyamoto, Haruhide Kimura
Publikováno v:
Pharmacology Research & Perspectives, Vol 8, Iss 1, Pp n/a-n/a (2020)
Abstract M1 muscarinic acetylcholine receptor (M1R) activation can be a new therapeutic approach for the treatment of cognitive deficits associated with cholinergic hypofunction. However, M1R activation causes gastrointestinal (GI) side effects in an
Externí odkaz:
https://doaj.org/article/1996db5c1bb74209a2c1a0e72f2d9b18
Publikováno v:
PLoS ONE, Vol 14, Iss 3, p e0207969 (2019)
Activation of the muscarinic M1 receptor is a promising approach to improve cognitive deficits associated with cholinergic dysfunction in Alzheimer's disease, dementia with Lewy bodies, and schizophrenia. TAK-071 is an M1-selective positive allosteri
Externí odkaz:
https://doaj.org/article/9eb42a220ef7469e846e76032424432b
Autor:
Haruhide Kimura, Hiroshi Yukitake, Hirobumi Suzuki, Yasukazu Tajima, Koyo Gomaibashi, Shinji Morimoto, Yasunori Funabashi, Kiyofumi Yamada, Masayuki Takizawa
Publikováno v:
Journal of Pharmacological Sciences, Vol 110, Iss 2, Pp 201-211 (2009)
Abstract.: In a screening program aimed at discovering anti-osteoarthritis (OA) drugs, we identified an imidazo[5,1-c][1,4]thiazine derivative, ITZ-1, that suppressed both interleukin-1β (IL-1β)-induced proteoglycan and collagen release from bovine
Externí odkaz:
https://doaj.org/article/7223aea5d91a48dc9b789423b7d410f2