DeepCLIP: predicting the effect of mutations on protein-RNA binding with deep learning.

Autor: Grønning AGB; Department of Biochemistry and Molecular Biology, University of Southern Denmark, 5230 Odense M, Denmark.; Villum Center for Bioanalytical Sciences, University of Southern Denmark, 5230 Odense M, Denmark.; Department of Mathematics and Computer Science, University of Southern Denmark, 5230 Odense M, Denmark., Doktor TK; Department of Biochemistry and Molecular Biology, University of Southern Denmark, 5230 Odense M, Denmark.; Villum Center for Bioanalytical Sciences, University of Southern Denmark, 5230 Odense M, Denmark., Larsen SJ; Department of Mathematics and Computer Science, University of Southern Denmark, 5230 Odense M, Denmark., Petersen USS; Department of Biochemistry and Molecular Biology, University of Southern Denmark, 5230 Odense M, Denmark.; Villum Center for Bioanalytical Sciences, University of Southern Denmark, 5230 Odense M, Denmark., Holm LL; Department of Biochemistry and Molecular Biology, University of Southern Denmark, 5230 Odense M, Denmark.; Villum Center for Bioanalytical Sciences, University of Southern Denmark, 5230 Odense M, Denmark., Bruun GH; Department of Biochemistry and Molecular Biology, University of Southern Denmark, 5230 Odense M, Denmark.; Villum Center for Bioanalytical Sciences, University of Southern Denmark, 5230 Odense M, Denmark., Hansen MB; Department of Biochemistry and Molecular Biology, University of Southern Denmark, 5230 Odense M, Denmark.; Villum Center for Bioanalytical Sciences, University of Southern Denmark, 5230 Odense M, Denmark., Hartung AM; Department of Biochemistry and Molecular Biology, University of Southern Denmark, 5230 Odense M, Denmark.; Villum Center for Bioanalytical Sciences, University of Southern Denmark, 5230 Odense M, Denmark., Baumbach J; Department of Mathematics and Computer Science, University of Southern Denmark, 5230 Odense M, Denmark.; Chair of Experimental Bioinformatics, TUM School of Life Sciences Weihenstephan, Technical University of Munich, 85354 Freising, Germany., Andresen BS; Department of Biochemistry and Molecular Biology, University of Southern Denmark, 5230 Odense M, Denmark.; Villum Center for Bioanalytical Sciences, University of Southern Denmark, 5230 Odense M, Denmark.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2020 Jul 27; Vol. 48 (13), pp. 7099-7118.

The Splicing Efficiency of Activating HRAS Mutations Can Determine Costello Syndrome Phenotype and Frequency in Cancer.

Autor: Hartung AM; Department of Biochemistry and Molecular Biology and The Villum Center for Bioanalytical Sciences, University of Southern Denmark, Odense M, Denmark., Swensen J; Caris Life Sciences, Phoenix, Arizona, United States of America.; Department of Pathology, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.; ARUP Laboratories, Salt Lake City, Utah, United States of America., Uriz IE; Department of Biochemistry and Molecular Biology and The Villum Center for Bioanalytical Sciences, University of Southern Denmark, Odense M, Denmark., Lapin M; Department of Biochemistry and Molecular Biology and The Villum Center for Bioanalytical Sciences, University of Southern Denmark, Odense M, Denmark., Kristjansdottir K; Department of Biochemistry and Molecular Biology and The Villum Center for Bioanalytical Sciences, University of Southern Denmark, Odense M, Denmark., Petersen US; Department of Biochemistry and Molecular Biology and The Villum Center for Bioanalytical Sciences, University of Southern Denmark, Odense M, Denmark., Bang JM; Department of Biochemistry and Molecular Biology and The Villum Center for Bioanalytical Sciences, University of Southern Denmark, Odense M, Denmark., Guerra B; Department of Biochemistry and Molecular Biology and The Villum Center for Bioanalytical Sciences, University of Southern Denmark, Odense M, Denmark., Andersen HS; Department of Biochemistry and Molecular Biology and The Villum Center for Bioanalytical Sciences, University of Southern Denmark, Odense M, Denmark., Dobrowolski SF; Department of Pathology, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, United States of America., Carey JC; Department of Pediatrics, University of Utah, Salt Lake City, Utah, United States of America., Yu P; ARUP Laboratories, Salt Lake City, Utah, United States of America., Vaughn C; ARUP Laboratories, Salt Lake City, Utah, United States of America., Calhoun A; Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, United States of America., Larsen MR; Department of Biochemistry and Molecular Biology and The Villum Center for Bioanalytical Sciences, University of Southern Denmark, Odense M, Denmark., Dyrskjøt L; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark., Stevenson DA; Division of Medical Genetics, Stanford University, Stanford, California, United States of America., Andresen BS; Department of Biochemistry and Molecular Biology and The Villum Center for Bioanalytical Sciences, University of Southern Denmark, Odense M, Denmark.

Publikováno v: PLoS genetics [PLoS Genet] 2016 May 19; Vol. 12 (5), pp. e1006039. Date of Electronic Publication: 2016 May 19 (Print Publication: 2016).

A selective delta opioid receptor antagonist based on a stilbene core.

Autor: Hartung AM; Department of Chemistry, The University of Iowa, Chemistry Building, Iowa City, IA 52242-1294, United States., Navarro HA; Discovery Sciences, RTI International, Research Triangle Park, NC 27709, United States., Wiemer DF; Department of Chemistry, The University of Iowa, Chemistry Building, Iowa City, IA 52242-1294, United States., Neighbors JD; Department of Chemistry, The University of Iowa, Chemistry Building, Iowa City, IA 52242-1294, United States; Department of Pharmacology, Pennsylvania State University Hershey College of Medicine, Hershey, PA 17033, United States; Penn State Hershey Cancer Institute, Hershey, PA 17033, United States.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2015 Dec 01; Vol. 25 (23), pp. 5532-5. Date of Electronic Publication: 2015 Oct 23.