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Entry of substances into perilymph through the bone of the otic capsule after intratympanic applications in guinea pigs: implications for local drug delivery in humans.

Autor: Mikulec AA, Plontke SK, Hartsock JJ, Salt AN, Mikulec, Anthony A, Plontke, Stefan K, Hartsock, Jared J, Salt, Alec N

Publikováno v: Otology & Neurotology; 2009 Feb, Vol. 30 Issue 2, p131-138, 8p

A Guinea Pig Model Suggests That Objective Assessment of Acoustic Hearing Preservation in Human Ears With Cochlear Implants Is Confounded by Shifts in the Spatial Origin of Acoustically Evoked Potential Measurements Along the Cochlear Length.

Autor: Lee C; Department of Otolaryngology, University of Rochester, Rochester, New York, USA., Hartsock JJ; Department of Cochlear Surgery, Turner Scientific, Inc., Jacksonville, Illinois, USA., Salt AN; Department of Pharmacokinetics, Turner Scientific, Inc., Jacksonville, Illinois, USA., Lichtenhan JT; Department of Otolaryngology, University of South Florida Morsani School of Medicine, Tampa, Florida, USA.

Publikováno v: Ear and hearing [Ear Hear] 2024 May-Jun 01; Vol. 45 (3), pp. 666-678. Date of Electronic Publication: 2024 Jan 05.

Improved Speech Intelligibility in Subjects With Stable Sensorineural Hearing Loss Following Intratympanic Dosing of FX-322 in a Phase 1b Study.

Autor: McLean WJ; Frequency Therapeutics, Woburn, MA & Farmington, CT.; Department of Surgery, University of Connecticut School of Medicine, Farmington, CT., Hinton AS; Frequency Therapeutics, Woburn, MA & Farmington, CT., Herby JTJ; Frequency Therapeutics, Woburn, MA & Farmington, CT., Salt AN; Department of Otolaryngology, Central Institute for the Deaf, Fay and Carl Simons Center for Hearing and Deafness, Washington University School of Medicine, Saint Louis, MO., Hartsock JJ; Department of Otolaryngology, Central Institute for the Deaf, Fay and Carl Simons Center for Hearing and Deafness, Washington University School of Medicine, Saint Louis, MO., Wilson S; Frequency Therapeutics, Woburn, MA & Farmington, CT., Lucchino DL; Frequency Therapeutics, Woburn, MA & Farmington, CT., Lenarz T; Department of Otolaryngology and Cluster of Excellence of the German Research Foundation 'Hearing4all', Hannover Medical School, Hannover, Germany., Warnecke A; Department of Otolaryngology and Cluster of Excellence of the German Research Foundation 'Hearing4all', Hannover Medical School, Hannover, Germany., Prenzler N; Department of Otolaryngology and Cluster of Excellence of the German Research Foundation 'Hearing4all', Hannover Medical School, Hannover, Germany., Schmitt H; Department of Otolaryngology and Cluster of Excellence of the German Research Foundation 'Hearing4all', Hannover Medical School, Hannover, Germany., King S; Ear Medical Group., Jackson LE; Ear Institute of Texas, San Antonio, TX., Rosenbloom J; Alamo ENT Associates, San Antonio, TX., Atiee G; Worldwide Clinical Trials, San Antonio, TX., Bear M; Forsythe and Bear LLC, Woodland Hills, CA., Runge CL; Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, WI., Gifford RH; Department of Hearing and Speech Sciences, Vanderbilt University Medical Center, Nashville, TN., Rauch SD; Department of Otolaryngology, Harvard Medical School and Massachusetts Eye and Ear, Boston., Lee DJ; Department of Otolaryngology, Harvard Medical School and Massachusetts Eye and Ear, Boston., Langer R; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA., Karp JM; Center for Nanomedicine, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School Boston MA.; Harvard-MIT Division of Health Science and Technology.; Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA., Loose C; Frequency Therapeutics, Woburn, MA & Farmington, CT., LeBel C; Frequency Therapeutics, Woburn, MA & Farmington, CT.

Publikováno v: Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology [Otol Neurotol] 2021 Aug 01; Vol. 42 (7), pp. e849-e857.

Permeation Enhancers for Intratympanically-applied Drugs Studied Using Fluorescent Dexamethasone as a Marker.

Autor: Li W; Department of Otolaryngology, Eye, Ear, Nose, & Throat Hospital, Fudan University, Shanghai, China., Hartsock JJ; Department of Otolaryngology, Washington University School of Medicine, St Louis, Missouri., Dai C; Department of Otolaryngology, Eye, Ear, Nose, & Throat Hospital, Fudan University, Shanghai, China., Salt AN; Department of Otolaryngology, Washington University School of Medicine, St Louis, Missouri.

Publikováno v: Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology [Otol Neurotol] 2018 Jun; Vol. 39 (5), pp. 639-647.