Zobrazeno 1 - 10 of 45 pro vyhledávání: '"Hartmut M. Hanauske-Abel"'
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Akademický článek
Drug-Based Lead Discovery: The Novel Ablative Antiretroviral Profile of Deferiprone in HIV-1-Infected Cells and in HIV-Infected Treatment-Naive Subjects of a Double-Blind, Placebo-Controlled, Randomized Exploratory Trial.
Autor: Deepti Saxena, Michael Spino, Fernando Tricta, John Connelly, Bernadette M Cracchiolo, Axel-Rainer Hanauske, Darlene D'Alliessi Gandolfi, Michael B Mathews, Jonathan Karn, Bart Holland, Myung Hee Park, Tsafi Pe'ery, Paul E Palumbo, Hartmut M Hanauske-Abel
Publikováno v: PLoS ONE, Vol 11, Iss 5, p e0154842 (2016)
UNLABELLED:Antiretrovirals suppress HIV-1 production yet spare the sites of HIV-1 production, the HIV-1 DNA-harboring cells that evade immune detection and enable viral resistance on-drug and viral rebound off-drug. Therapeutic ablation of pathogenic
Externí odkaz: https://doaj.org/article/e17e5bea35ab4969b437207695534e81
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5
Akademický článek
Drug-induced reactivation of apoptosis abrogates HIV-1 infection.
Autor: Hartmut M Hanauske-Abel, Deepti Saxena, Paul E Palumbo, Axel-Rainer Hanauske, Augusto D Luchessi, Tavane D Cambiaghi, Mainul Hoque, Michael Spino, Darlene D'Alliessi Gandolfi, Debra S Heller, Sukhwinder Singh, Myung Hee Park, Bernadette M Cracchiolo, Fernando Tricta, John Connelly, Anthony M Popowicz, Richard A Cone, Bart Holland, Tsafi Pe'ery, Michael B Mathews
Publikováno v: PLoS ONE, Vol 8, Iss 9, p e74414 (2013)
HIV-1 blocks apoptosis, programmed cell death, an innate defense of cells against viral invasion. However, apoptosis can be selectively reactivated in HIV-infected cells by chemical agents that interfere with HIV-1 gene expression. We studied two glo
Externí odkaz: https://doaj.org/article/6c8d6c50e71847d2ba0749f5c2b0cea3
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6
Matrix recruitment by malignant cells (MRMC) in uterine serous carcinoma (USC)-derived ARK1 identifies the procurement of vessel wall components (VWCs) as novel therapeutic target
Autor: Axel-Rainer Hanauske, Seema Husain, Hartmut M. Hanauske-Abel, Patricia Soteropoulos, Bernadette Cracchiolo, Sukhwinder Singh, Mainul Hoque
Publikováno v: Gynecologic Oncology. 162:S204
Objectives: USC and its ovarian counterpart (OSC), the most lethal gynecologic malignancies, are resistant to current therapies. We noted that the highly annotated USC-derived cell line ARK1 lacks expression of collagen type III (COL3), the master or
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::55a245ee0d53446c3c0a0535b711d49d
https://doi.org/10.1016/s0090-8258(21)01039-8
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7
Abstract 2030: Oncological relevance of protein hydroxylase inhibitors (PHI): results of testing an emerging concept with an orally active pioneer medicine that blocks the hydroxylations of proline and lysine residues
Autor: Bernadette Cracchiolo, Sukhwinder Singh, Axel-Rainer Hanauske, Hartmut M. Hanauske-Abel
Publikováno v: Cancer Research. 81:2030-2030
Background & Objectives: 40 years ago, the HAG mechanism specified the sequence of orbital interactions that underlie the synthesis of peptide-bound hydroxyproline and hydroxylysine by ketoglutarate-utilizing dioxygenases. Instantly reducing this ins
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::148c86c819f650eb6f6354c0ca5076c4
https://doi.org/10.1158/1538-7445.am2021-2030
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8
Blocking eIF5A Modification in Cervical Cancer Cells Alters the Expression of Cancer-Related Genes and Suppresses Cell Proliferation
Autor: Hartmut M. Hanauske-Abel, Tsafi Pe'ery, Hong Li, Elisabeth Mémin, Bernadette Cracchiolo, Debra S. Heller, Mohit Jain, Michael B. Mathews, Mainul Hoque
Publikováno v: Cancer Research. 74:552-562
Cancer etiology is influenced by alterations in protein synthesis that are not fully understood. In this study, we took a novel approach to investigate the role of the eukaryotic translation initiation factor eIF5A in human cervical cancers, where it
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbba65be4df88ecb7a1bca10c4a913f0
https://doi.org/10.1158/0008-5472.can-13-0474
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9
Correlations of mRNA expression and in vitro chemosensitivity to enzastaurin in freshly explanted human tumor cells
Autor: Hartmut M. Hanauske-Abel, Victor J. Chen, Doreen Ma, Michael Lahn, Heike Pospisil, Ulrike Eismann, Axel-Rainer Hanauske, Olaf Oberschmidt, J. Blatter
Publikováno v: Investigational New Drugs. 26:215-222
Purpose: Enzastaurin (LY317615) is a novel serine/threonine kinase inhibitor, targeting Protein Kinase C-beta (PKC-β), and PI3K/AKT pathways to inhibit angiogenesis and tumor cell proliferation. The aims of this study were to determine whether Enzas
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ed361a79f7e04910fe4ec6ea34bcc0e
https://doi.org/10.1007/s10637-007-9095-y
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In vitro chemosensitivity of freshly explanted tumor cells to pemetrexed is correlated with target gene expression
Autor: Doreen Ma, Paolo Paoletti, Steve Hoffmann, Olaf Oberschmidt, Heike Pospisil, Clet Niyikiza, Hartmut M. Hanauske-Abel, Victor J. Chen, Axel-Rainer Hanauske, Ulrike Eismann
Publikováno v: Investigational New Drugs. 25:417-423
mRNA expression of genes involved in the mechanism of action of pemetrexed was correlated with in vitro chemosensitivity of freshly explanted human tumor specimens.Chemosensitivity to pemetrexed was studied in soft-agar. Multiplex rtPCR experiments f
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d143c61687cd6d6d7611ce26eaf7e6be
https://doi.org/10.1007/s10637-007-9060-9
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