Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Hartmut Kuhn"'
Autor:
Christian M. Zobel, Hartmut Kuhn, Maximilian Schreiner, Werner Wenzel, Jasper Wendtland, Cengiz Goekeri, Lorenz Scheit, Klaas Oltmanns, Dominic Rauschning, Marica Grossegesse, Natalie Hofmann, Hubert Wirtz, Sebastian Spethmann, BwKrhs-Covid-Research-Group
Publikováno v:
Virology Journal, Vol 21, Iss 1, Pp 1-13 (2024)
Abstract Background The coronavirus disease 2019 (COVID-19) pandemic is driven by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, which has led to an enormous burden on patient morbidity and mortality. The renin–angiotensin
Externí odkaz:
https://doaj.org/article/b8222daaad684eb7a26865861c22f3e5
Autor:
Florian Reisch, Dagmar Heydeck, Marjann Schäfer, Michael Rothe, Jiaxing Yang, Sabine Stehling, Gerhard P. Püschel, Hartmut Kuhn
Publikováno v:
Cellular & Molecular Biology Letters, Vol 28, Iss 1, Pp 1-25 (2023)
Abstract Arachidonic acid 15-lipoxygenases (ALOX15) play a role in mammalian erythropoiesis but they have also been implicated in inflammatory processes. Seven intact Alox genes have been detected in the mouse reference genome and the mouse Alox15 ge
Externí odkaz:
https://doaj.org/article/7c83cbe123094749a3d3a36998b23f6e
Autor:
Xiaoke Wu, Chi Chiu Wang, Yijuan Cao, Jian Li, Zhiqiang Li, Hongli Ma, Jingshu Gao, Hui Chang, Duojia Zhang, Jing Cong, Yu Wang, Qi Wu, Xiaoxiao Han, Pui Wah Jacqueline Chung, Yiran Li, Xu Zheng, Lingxi Chen, Lin Zeng, Astrid Borchert, Hartmut Kuhn, Zi-Jiang Chen, Ernest Hung Yu Ng, Elisabet Stener-Victorin, Heping Zhang, Richard S. Legro, Ben Willem J. Mol, Yongyong Shi
Publikováno v:
Engineering, Vol 23, Iss , Pp 103-111 (2023)
Ovulation induction is a first-line medical treatment for infertility in polycystic ovary syndrome (PCOS). Poor ovulation responses are assumed to be due to insulin resistance and hyperandrogenism. In a prospective cohort (PCOSAct) of 1000 infertile
Externí odkaz:
https://doaj.org/article/e1bddde78ec94cbb9a3e291e00022b2f
Publikováno v:
Antioxidants, Vol 13, Iss 2, p 242 (2024)
Ferroptosis is a special kind of programmed cell death that has been implicated in the pathogenesis of a large number of human diseases. It involves dysregulated intracellular iron metabolism and uncontrolled lipid peroxidation, which together initia
Externí odkaz:
https://doaj.org/article/336ec8a3b1504c0b941aab9b9ba60fe3
Autor:
Bernhard Dumoulin, Dagmar Heydeck, Desiree Jähn, Moritz Lassé, Sajad Sofi, Christoph Ufer, Hartmut Kuhn
Publikováno v:
Cell & Bioscience, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract The guanine-rich RNA sequence binding factor 1 (GRSF1) is an RNA-binding protein of the heterogenous nuclear ribonucleoprotein H/F (hnRNP H/F) family that binds to guanine-rich RNA sequences forming G-quadruplex structures. In mice and human
Externí odkaz:
https://doaj.org/article/89779ebe5f85492f9caae2074e54b6eb
Autor:
Sophie Roigas, Kumar R. Kakularam, Michael Rothe, Dagmar Heydeck, Polamarasetty Aparoy, Hartmut Kuhn
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 18, p 14154 (2023)
The human genome involves six functional arachidonic acid lipoxygenase (ALOX) genes and the corresponding enzymes (ALOX15, ALOX15B, ALOX12, ALOX12B, ALOXE3, ALOX5) have been implicated in cell differentiation and in the pathogenesis of inflammatory,
Externí odkaz:
https://doaj.org/article/e72034ee2d2341fdb90dd246eeebf133
Autor:
Hartmut Kuhn, Armin Frille, Marie Anna Petersen, Jonas Oberhuber-Kurth, Lukas Hofmann, Albrecht Gläser, Sabine Taubenheim, Sabine Klagges, Sebastian Kraemer, Johannes Broschewitz, Maximilian von Laffert, Hubert Wirtz
Publikováno v:
Translational Oncology, Vol 27, Iss , Pp 101566- (2023)
The insulin-like growth factor (IGF)-pathway is involved in tumor cell proliferation, metastasis, and survival. We aimed to find out what effects IGF binding protein 3 (IGFBP3) exerted on H1299 lung cancer (LC) cells in terms of tumor growth and inva
Externí odkaz:
https://doaj.org/article/ab51f75008454de5b1b889c501a93717
Autor:
Alexander Zhuravlev, Alejandro Cruz, Vladislav Aksenov, Alexey Golovanov, José M. Lluch, Hartmut Kuhn, Àngels González-Lafont, Igor Ivanov
Publikováno v:
Molecules, Vol 28, Iss 14, p 5418 (2023)
Mammalian 15-lipoxygenases (ALOX15) are lipid peroxidizing enzymes that exhibit variable functionality in different cancer and inflammation models. The pathophysiological role of linoleic acid- and arachidonic acid-derived ALOX15 metabolites rendered
Externí odkaz:
https://doaj.org/article/b3192ec52c6a4506b2e37cd8615decaa
Autor:
Marjann Schäfer, Florian Reisch, Dominika Labuz, Halina Machelska, Sabine Stehling, Gerhard P. Püschel, Michael Rothe, Dagmar Heydeck, Hartmut Kuhn
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 11034 (2023)
Mammalian arachidonic acid lipoxygenases (ALOXs) have been implicated in the pathogenesis of inflammatory diseases, and its pro- and anti-inflammatory effects have been reported for different ALOX-isoforms. Human ALOX15B oxygenates arachidonic acid t
Externí odkaz:
https://doaj.org/article/9dea358c140149189ab9d2eb5e3daf46
Autor:
Kumar R. Kakularam, Miquel Canyelles-Niño, Xin Chen, José M. Lluch, Àngels González-Lafont, Hartmut Kuhn
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 12, p 10046 (2023)
The arachidonic acid lipoxygenase 15B (ALOX15B) orthologs of men and mice form different reaction products when arachidonic acid is used as the substrate. Tyr603Asp+His604Val double mutation in mouse arachidonic acid lipoxygenase 15b humanized the pr
Externí odkaz:
https://doaj.org/article/4a9bba2dd3ea48e68f9ffd1ebb2a59d9