Zobrazeno 1 - 10
of 271
pro vyhledávání: '"Hartmut J Ehrlich"'
Autor:
Pedro Giavina-Bianchi, MD, PhD, Eric Cua, MD, Karine Risso, MD, Véronique Mondain, MD, Anaïs Vissian, MSc, Cécile Joie, MSc, Philippe Pouletty, MD, Paul Gineste, PharmD, Hartmut J. Ehrlich, MD, PhD, Jorge Kalil, MD, PhD
Publikováno v:
Journal of Allergy and Clinical Immunology: Global, Vol 2, Iss 4, Pp 100140- (2023)
Background: ABX464 (obefazimod) is a small molecule that upregulates a single microRNA (miR-124) in immune cells and reduces the production of various inflammatory cytokines and chemokines. Objective: We assessed the efficacy and safety of the standa
Externí odkaz:
https://doaj.org/article/38018d98dfd24036bb65e23f3e7a3be0
Autor:
Sofie Rutsaert, Jean-Marc Steens, Paul Gineste, Basiel Cole, Sam Kint, P. Noel Barrett, Jamal Tazi, Didier Scherrer, Hartmut J. Ehrlich, Linos Vandekerckhove
Publikováno v:
Journal of Virus Eradication, Vol 5, Iss 1, Pp 10-22 (2019)
Objectives: To assess the safety and tolerability as well as antiretroviral impact of ABX464, an oral investigational drug with a novel mechanism of HIV-1 inhibition (ClinicalTrials.gov NCT02735863). Methods: Randomised, double-blind, placebo-control
Externí odkaz:
https://doaj.org/article/3ef3f0db63364cc288365e8f7330998c
Autor:
Didier Scherrer, Noel Barrett, Luc Teyton, Tillman Pearce, Josianne Nitcheu, Philippe Pouletty, Julien Santo, Hartmut J. Ehrlich
Publikováno v:
Molecular Cancer Therapeutics. 21:1788-1797
Immune checkpoint blockers (ICB) provide a promising approach to antitumor immunotherapy through blockade of immunosuppressive pathways. The synthetic glycolipid, ABX196, is a potent stimulator of invariant natural killer T cells (iNKT), a small subs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9511278906cbb4781ed51358308534dc
https://doi.org/10.1158/1535-7163.mct-22-0183
https://doi.org/10.1158/1535-7163.mct-22-0183
Autor:
Karim Chebli, Laura Papon, Conception Paul, Aude Garcel, Noëlie Campos, Didier Scherrer, Hartmut J. Ehrlich, Michael Hahne, Jamal Tazi
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract The progression of human immunodeficiency virus (HIV) is associated with mucosal damage in the gastrointestinal (GI) tract. This damage enables bacterial translocation from the gut and leads to subsequent inflammation. Dextran sulfate sodium
Externí odkaz:
https://doaj.org/article/908d748ddfcb49b68fb516df8640bcdd
Autor:
Hartmut J. Ehrlich, Julien Santo, Philippe Pouletty, Josianne Nitcheu, Tillman Pearce, Luc Teyton, Noel Barrett, Didier Scherrer
Supplementary Figure from Demonstration of the Antitumor Activity of the iNKT Agonist ABX196, a Novel Enhancer of Cancer Immunotherapy, in Melanoma and Hepatocarcinoma Mouse Models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::756179482cb9b7fcd36a3727c5756534
https://doi.org/10.1158/1535-7163.22523904.v1
https://doi.org/10.1158/1535-7163.22523904.v1
Autor:
Hartmut J. Ehrlich, Julien Santo, Philippe Pouletty, Josianne Nitcheu, Tillman Pearce, Luc Teyton, Noel Barrett, Didier Scherrer
Supplementary Data from Demonstration of the Antitumor Activity of the iNKT Agonist ABX196, a Novel Enhancer of Cancer Immunotherapy, in Melanoma and Hepatocarcinoma Mouse Models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::609130139a65ecaaa5d286825fc3a9af
https://doi.org/10.1158/1535-7163.22523910.v1
https://doi.org/10.1158/1535-7163.22523910.v1
Autor:
Severine Vermeire, Bruce E Sands, Herbert Tilg, Zsolt Tulassay, Radoslaw Kempinski, Silvio Danese, Ivan Bunganič, Josianne Nitcheu, Julien Santo, Didier Scherrer, Sophie Biguenet, Hartmut J Ehrlich, Jean-Marc Steens, Paul Gineste, William J Sandborn
Publikováno v:
The lancet. Gastroenterologyhepatology. 7(11)
ABX464 (obefazimod) is a small molecule that selectively upregulates miR-124 in immune cells. We aimed to assess ABX464 as a treatment for patients with moderate-to-severe, active ulcerative colitis.In this phase 2b, double-blind, randomised, placebo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f4ad9b227f29c184aeae9ac895873a2
https://pubmed.ncbi.nlm.nih.gov/36075248
https://pubmed.ncbi.nlm.nih.gov/36075248
Autor:
Alfred T Welzel, Angela D Williams, Helen P McWilliams-Koeppen, Luis Acero, Alfred Weber, Veronika Blinder, Alex Mably, Sebastian Bunk, Corinna Hermann, Michael A Farrell, Hartmut J Ehrlich, Hans P Schwarz, Dominic M Walsh, Alan Solomon, Brian O'Nuallain
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50317 (2012)
Soluble non-fibrillar assemblies of amyloid-beta (Aβ) and aggregated tau protein are the proximate synaptotoxic species associated with Alzheimer's disease (AD). Anti-Aβ immunotherapy is a promising and advanced therapeutic strategy, but the precis
Externí odkaz:
https://doaj.org/article/b5e5d024a32647f4acc8c5e30db8eff6
Autor:
M Keith Howard, Nicolas Sabarth, Helga Savidis-Dacho, Daniel Portsmouth, Otfried Kistner, Thomas R Kreil, Hartmut J Ehrlich, P Noel Barrett
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23791 (2011)
Vero cell culture-derived whole-virus H5N1 vaccines have been extensively tested in clinical trials and consistently demonstrated to be safe and immunogenic; however, clinical efficacy is difficult to evaluate in the absence of wide-spread human dise
Externí odkaz:
https://doaj.org/article/205eb7c48865410f8d91f4c9ce60e609
Autor:
Annett Hessel, Michael Schwendinger, Georg W Holzer, Klaus K Orlinger, Sogue Coulibaly, Helga Savidis-Dacho, Marie-Luise Zips, Brian A Crowe, Thomas R Kreil, Hartmut J Ehrlich, P Noel Barrett, Falko G Falkner
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e16247 (2011)
BACKGROUND: New highly pathogenic H5N1 influenza viruses are continuing to evolve with a potential threat for an influenza pandemic. So far, the H5N1 influenza viruses have not widely circulated in humans and therefore constitute a high risk for the
Externí odkaz:
https://doaj.org/article/aa02955da4be48a892c3e65736b41f70