Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Hartmut H. Niemann"'
Autor:
Yunqing Li, Serena M. Arghittu, Marina S. Dietz, Gabriel J. Hella, Daniel Haße, Davide M. Ferraris, Petra Freund, Hans-Dieter Barth, Luisa Iamele, Hugo de Jonge, Hartmut H. Niemann, Roberto Covino, Mike Heilemann
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Embedding of cell-surface receptors into a membrane defines their dynamics but also complicates experimental characterization of their signaling complexes. The hepatocyte growth factor receptor MET is a receptor tyrosine kinase involved in c
Externí odkaz:
https://doaj.org/article/98dfe12d836b4598a39f3d730b372ba1
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Recruitment of substrates to virulent bacterial type III secretion systems remains enigmatic. Here, a crystal structure reveals two binding sites between a secretion substrate in complex with its chaperone and the cytosolic domain of the export gate.
Externí odkaz:
https://doaj.org/article/563d4199679042c89f7bdd65419b5226
Autor:
Marie‐Lena I. E. Harwardt, Phoebe Young, Willem M. Bleymüller, Timo Meyer, Christos Karathanasis, Hartmut H. Niemann, Mike Heilemann, Marina S. Dietz
Publikováno v:
FEBS Open Bio, Vol 7, Iss 9, Pp 1422-1440 (2017)
The human MET receptor tyrosine kinase contributes to vertebrate development and cell proliferation. As a proto‐oncogene, it is a target in cancer therapies. MET is also relevant for bacterial infection by Listeria monocytogenes and is activated by
Externí odkaz:
https://doaj.org/article/8d1956ed432449619e59ff2f74371592
Publikováno v:
Crystals, Vol 10, Iss 12, p 1135 (2020)
Flavin-dependent halogenases chlorinate or brominate their substrates in an environmentally friendly manner, only requiring the cofactor reduced flavin adenine dinucleotide (FADH2), oxygen, and halide salts. The tryptophan 6-halogenase Thal exhibits
Externí odkaz:
https://doaj.org/article/68a2b5bd29d543478155334b2dbb04a3
Autor:
Frank Lüdel, Sandra Bufe, Willem M. Bleymüller, Hugo de Jonge, Luisa Iamele, Hartmut H. Niemann, Thomas Hellweg
Publikováno v:
Antibodies, Vol 8, Iss 4, p 48 (2019)
Depending on the linker length between the V H and the V L domain, single-chain Fv (scFv) antibody fragments form monomers, dimers (diabodies) or higher oligomers. We aimed at generating a diabody of the anti-MET antibody 3H3 to use it as crystalliza
Externí odkaz:
https://doaj.org/article/2fc6d4794d3a480d9c9d496cb77a24c1
Publikováno v:
Acta Crystallographica Section D Structural Biology. 79
Gram-negative bacteria such as Aeromonas and Yersinia spp. have developed mechanisms to inhibit the immune defense of their host. Effector proteins are directly injected into the host cytoplasm from the bacterial cytosol via type III secretion system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7e3087ddbda66c456d01d00c390df55
https://doi.org/10.1107/s2059798323003248
https://doi.org/10.1107/s2059798323003248
Autor:
Philipp Hansen, Thomas Haubenthal, Caroline Reiter, Jana Kniewel, Karla Bosse-Plois, Hartmut H. Niemann, Kristine von Bargen, Albert Haas
Virulence-associated protein A (VapA) of Rhodococcus equi is a pathogenicity factor required for the multiplication of virulent R. equi strains within spacious macrophage vacuoles. The production of VapA is characteristic for R. equi isolates from pn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eca874ef067bbf8f771873f41df24578
https://doi.org/10.1128/spectrum.03417-22
https://doi.org/10.1128/spectrum.03417-22
Autor:
Christian Schnepel, Ann‐Christin Moritzer, Simon Gäfe, Nicolai Montua, Hannah Minges, Anke Nieß, Hartmut H. Niemann, Norbert Sewald
Publikováno v:
ChemBioChem 24(1), e202200569 (2023). doi:10.1002/cbic.202200569
ChemBioChem 24(1), e202200569 (2023). doi:10.1002/cbic.202200569
The late-stage site-selective derivatisation of peptides has many potential applications in structure-activity relationship studies and postsynthetic modification or conjugation of
The late-stage site-selective derivatisation of peptides has many potential applications in structure-activity relationship studies and postsynthetic modification or conjugation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aaa598dca5a7569a80fd383d1b19ade
https://pubmed.ncbi.nlm.nih.gov/36259362
https://pubmed.ncbi.nlm.nih.gov/36259362
Publikováno v:
Acta crystallographica / Section D 78(3), 310-320 (2022). doi:10.1107/S2059798322000432
Acta crystallographica / Section D 78(3), 310 - 320 (2022). doi:10.1107/S2059798322000432
InlB, a bacterial agonist of the human receptor tyrosine kinase MET, consists of an N-terminal internalin domain, a central B repeat and three C-terminal G
InlB, a bacterial agonist of the human receptor tyrosine kinase MET, consists of an N-terminal internalin domain, a central B repeat and three C-terminal G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dfdf4ba3c6806bb7b65e80310ac2345
https://doi.org/10.1107/s2059798322000432
https://doi.org/10.1107/s2059798322000432
Publikováno v:
Acta crystallographica / F 77(8), 246-253 (2021). doi:10.1107/S2053230X2100738X
Acta Crystallographica. Section F, Structural Biology Communications
Acta Crystallographica. Section F, Structural Biology Communications
Acta crystallographica / F 77(8), 246 - 253 (2021). doi:10.1107/S2053230X2100738X
Virulence-associated proteins (Vaps) contribute to the virulence of the pathogen Rhodococcus equi, but their mode of action has remained elusive. All Vaps share a
Virulence-associated proteins (Vaps) contribute to the virulence of the pathogen Rhodococcus equi, but their mode of action has remained elusive. All Vaps share a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8ae5207dec1158b058e7ef5d4f97848