Výsledky vyhledávání - "Hartmut H-J Schmidt"

Akademický článek

Evaluation of Therapeutic Oligonucleotides for Familial Amyloid Polyneuropathy in Patient-Derived Hepatocyte-Like Cells.

Autor: Christoph J Niemietz, Vanessa Sauer, Jacqueline Stella, Lutz Fleischhauer, Gursimran Chandhok, Sarah Guttmann, Yesim Avsar, Shuling Guo, Elizabeth J Ackermann, Jared Gollob, Brett P Monia, Andree Zibert, Hartmut H-J Schmidt

Publikováno v: PLoS ONE, Vol 11, Iss 9, p e0161455 (2016)

Familial amyloid polyneuropathy (FAP) is caused by mutations of the transthyretin (TTR) gene, predominantly expressed in the liver. Two compounds that knockdown TTR, comprising a small interfering RNA (siRNA; ALN-TTR-02) and an antisense oligonucleot

Externí odkaz: https://doaj.org/article/1796834c54db428483d9067e5e8d8e11

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Akademický článek

Enhanced monitoring and detection of recent genotype 3 hepatitis E virus infection through urine antigen testing

Autor: Yannick Stahl, Iyad Kabar, Hauke Heinzow, Benjamin Maasoumy, Birgit Bremer, Heiner Wedemeyer, Hartmut H.-J. Schmidt, Thomas Pietschmann, Bernhard Schlevogt, Patrick Behrendt

Publikováno v: Emerging Microbes and Infections, Vol 12, Iss 2 (2023)

Hepatitis E virus (HEV) is the leading cause of acute viral hepatitis. Numerous studies have investigated the dynamics of HEV infection markers, but the most suitable marker for diagnosing ongoing or recent HEV infection remains to be determined. Rec

Externí odkaz: https://doaj.org/article/4bd99d018d8f4f499d2695a8b3e51829

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Akademický článek

In Vitro and In Vivo Effects of SerpinA1 on the Modulation of Transthyretin Proteolysis

Autor: Filipa Bezerra, Christoph Niemietz, Hartmut H. J. Schmidt, Andree Zibert, Shuling Guo, Brett P. Monia, Paula Gonçalves, Maria João Saraiva, Maria Rosário Almeida

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 17, p 9488 (2021)

Transthyretin (TTR) proteolysis has been recognized as a complementary mechanism contributing to transthyretin-related amyloidosis (ATTR amyloidosis). Accordingly, amyloid deposits can be composed mainly of full-length TTR or contain a mixture of bot

Externí odkaz: https://doaj.org/article/9598f61fae504c5d9b4d47465e37d339

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Akademický článek

Non-deletion mutations in Egyptian patients with Duchenne muscular dystrophy

Autor: Rabah M. Shawky, Solaf M. Elsayed, Theodor Todorov, Andree Zibert, Salem Alawbathani, Hartmut H.-J. Schmidt

Publikováno v: Egyptian Journal of Medical Human Genetics, Vol 15, Iss 3, Pp 235-240 (2014)

Duchenne muscular dystrophy (DMD) is the most common form of muscular dystrophies affecting approximately 1:3500 male live births. Deletion of the dystrophin gene accounts for approximately 65% of mutations, duplications occur in 6–10% while the re

Externí odkaz: https://doaj.org/article/cd02fa7c4f684aff8f973309c439155e

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