Zobrazeno 1 - 10
of 214
pro vyhledávání: '"Hartmut H Schmidt"'
Autor:
Sarah Guttmann, Oksana Nadzemova, Inga Grünewald, Malte Lenders, Eva Brand, Andree Zibert, Hartmut H Schmidt
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0230025 (2020)
Intestinal cells control delivery of lipids to the body by adsorption, storage and secretion. Copper (Cu) is an important trace element and has been shown to modulate lipid metabolism. Mutation of the liver Cu exporter ATP7B is the cause of Wilson di
Externí odkaz:
https://doaj.org/article/151f7ce376c84391bfcf6f190e687253
Autor:
Michael Pöhler, Sarah Guttmann, Oksana Nadzemova, Malte Lenders, Eva Brand, Andree Zibert, Hartmut H Schmidt, Vanessa Sandfort
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0239411 (2020)
Wilson's disease (WD) is a monogenetic liver disease that is based on a mutation of the ATP7B gene and leads to a functional deterioration in copper (Cu) excretion in the liver. The excess Cu accumulates in various organs such as the liver and brain.
Externí odkaz:
https://doaj.org/article/706fad175a1d41b39f76ed6dd808173b
Imaging-based diagnosis of sarcopenia for transplant-free survival in primary sclerosing cholangitis
Autor:
Pedram Keshoofi, Philipp Schindler, Florian Rennebaum, Friederike Cordes, Haluk Morgul, Moritz Wildgruber, Hauke S. Heinzow, Andreas Pascher, Hartmut H. Schmidt, Anna Hüsing-Kabar, Michael Praktiknjo, Jonel Trebicka, Leon Louis Seifert
Publikováno v:
BMC Gastroenterology, Vol 24, Iss 1, Pp 1-11 (2024)
Abstract Background Imaging-based assessment of sarcopenia is a well-validated prognostic tool for patients with chronic liver disease. However, little is known about its value in patients with primary sclerosing cholangitis (PSC). This cross-section
Externí odkaz:
https://doaj.org/article/5d904cb42d524456aa6fbff3d7cb3343
Autor:
Sameer A Dhayat, Anna Hüsing, Norbert Senninger, Hartmut H Schmidt, Jörg Haier, Heiner Wolters, Iyad Kabar
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140066 (2015)
In this clinical study, we aimed to evaluate the role of circulating microRNA-200 family as a non-invasive tool to identify patients with cirrhosis-associated hepatocellular carcinoma (HCC).Prognosis of HCC remains poor with increasing incidence worl
Externí odkaz:
https://doaj.org/article/7f17c11ccd884e61a70435dfd25e7af0
Autor:
Stefan Schefczyk, Xufeng Luo, Yaojie Liang, Mike Hasenberg, Bernd Walkenfort, Martin Trippler, Jonas Schuhenn, Kathrin Sutter, Mengji Lu, Heiner Wedemeyer, Hartmut H. Schmidt, Ruth Broering
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Hepatitis B virus (HBV)-transgenic mice exhibit competent innate immunity and are therefore an ideal model for considering intrinsic or cell-based mechanisms in HBV pathophysiology. A highly replicative model that has been little used, let a
Externí odkaz:
https://doaj.org/article/d8033cbdd44a4c2e8375ba24f2d4d013
Autor:
Yaojie Liang, Xufeng Luo, Stefan Schefczyk, Lorraine T. Muungani, Hui Deng, Baoju Wang, Hideo A. Baba, Mengji Lu, Heiner Wedemeyer, Hartmut H. Schmidt, Ruth Broering
Publikováno v:
JHEP Reports, Vol 6, Iss 4, Pp 101012- (2024)
Background & Aims: Hepatitis B surface antigen (HBsAg) drives hepatocarcinogenesis. Factors and mechanisms involved in this progression remain poorly defined, hindering the development of effective therapeutic strategies. Therefore, the mechanisms in
Externí odkaz:
https://doaj.org/article/021c294eb0fa4e82a3c04f7fbcee6c73
Autor:
Ayaz Sapuk, Leonie Steinhoff, Kristin Huenninghaus, Katharina Willuweit, Jassin Rashidi Alavijeh, Benedikt Hild, Lucia Asar, Hartmut H. Schmidt, Christoph Schramm
Publikováno v:
Canadian Journal of Gastroenterology and Hepatology, Vol 2024 (2024)
Bulevirtide (BLV) is approved for the treatment of chronic hepatitis D (CHD). Because only limited long-term experience has been reported, we aimed to evaluate the efficacy and safety of BLV treatment in patients with advanced chronic liver disease (
Externí odkaz:
https://doaj.org/article/9d99b582b695458a9d1559cc5ee2ebc6
Publikováno v:
Journal of Personalized Medicine, Vol 14, Iss 4, p 370 (2024)
Hepatocellular carcinoma (HCC) is a common complication of chronic liver diseases and remains a relevant cause of cancer-related mortality worldwide. The global prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) as a risk
Externí odkaz:
https://doaj.org/article/62d71446a8f44d7ca6ed69dc9cdf8a05
Autor:
Georgios Konstantis, Georgia Tsaousi, Chryssa Pourzitaki, Stefan Kasper-Virchow, Gregor Zaun, Elisavet Kitsikidou, Moritz Passenberg, Vasilis Spyridon Tseriotis, Katharina Willuweit, Hartmut H. Schmidt, Jassin Rashidi-Alavijeh
Publikováno v:
Cancers, Vol 16, Iss 7, p 1280 (2024)
Objective: Gastric carcinoma (GC) is the fifth most commonly diagnosed cancer and the third leading cause of cancer-related deaths globally. The tumor microenvironment plays a significant role in the pathogenesis, prognosis, and response to immunothe
Externí odkaz:
https://doaj.org/article/6ed8dc2832424b6dbc907cdf97d2ee8d
Autor:
Agnese Padula, Raffaella Petruzzelli, Sasha A. Philbert, Stephanie J. Church, Federica Esposito, Severo Campione, Marcello Monti, Filomena Capolongo, Claudia Perna, Edoardo Nusco, Hartmut H. Schmidt, Alberto Auricchio, Garth J.S. Cooper, Roman Polishchuk, Pasquale Piccolo
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 26, Iss , Pp 495-504 (2022)
Wilson disease (WD) is a genetic disorder of copper homeostasis, caused by deficiency of the copper transporter ATP7B. Gene therapy with recombinant adeno-associated vectors (AAV) holds promises for WD treatment. However, the full-length human ATP7B
Externí odkaz:
https://doaj.org/article/9b06f42f269f4eb08bec78339d8b5af7