Dieter Oesterhelt (1940–2022): Life with light and color, pioneer of membrane protein research

Autor: Peter Hegemann, Hartmut Michel

Publikováno v: Biophysics and Physicobiology, Vol 20 (2023)

Externí odkaz: https://doaj.org/article/82f440f16f01415297e1b39f841f7467

The cryo-EM structure of the bd oxidase from M. tuberculosis reveals a unique structural framework and enables rational drug design to combat TB

Autor: Schara Safarian, Helen K. Opel-Reading, Di Wu, Ahmad R. Mehdipour, Kiel Hards, Liam K. Harold, Melanie Radloff, Ian Stewart, Sonja Welsch, Gerhard Hummer, Gregory M. Cook, Kurt L. Krause, Hartmut Michel

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)

M. tuberculosis cytochrome bd oxidase is of interest as a TB drug target. Here, the authors present the 2.5 Å cryo-EM structure of M. tuberculosis cytochrome bd oxidase and identify a disulfide bond within the canonical quinol binding and oxidation

Externí odkaz: https://doaj.org/article/d59d3dd24560451195a1764a95c9ea6d

Isolated Heme A Synthase from Aquifex aeolicus Is a Trimer

Autor: Hui Zeng, Guoliang Zhu, Shuangbo Zhang, Xinmei Li, Janosch Martin, Nina Morgner, Fei Sun, Guohong Peng, Hao Xie, Hartmut Michel

Publikováno v: mBio, Vol 11, Iss 3 (2020)

ABSTRACT The integral membrane protein heme A synthase (HAS) catalyzes the biosynthesis of heme A, which is a prerequisite for cellular respiration in a wide range of aerobic organisms. Previous studies have revealed that HAS can form homo-oligomeric

Externí odkaz: https://doaj.org/article/373e80c3052d423d82f3ea674c8bff61

Structural and functional investigation of ABC transporter STE6-2p from

Autor: E Sabine M, Schleker, Sabine, Buschmann, Hao, Xie, Sonja, Welsch, Hartmut, Michel, Christoph, Reinhart

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 119(43)

Adenosine triphosphate (ATP)-binding cassette (ABC) transporters are multidomain transmembrane proteins, which facilitate the transport of various substances across cell membranes using energy derived from ATP hydrolysis. They are important drug targ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::308a6ffd8e262103c3e1792f9c58fd5c
https://pubmed.ncbi.nlm.nih.gov/36256814

Mechanistic and structural diversity between cytochrome bd isoforms of Escherichia coli

Autor: Tamara N. Grund, Melanie Radloff, Di Wu, Hojjat G. Goojani, Luca F. Witte, Wiebke Jösting, Sabine Buschmann, Hannelore Müller, Isam Elamri, Sonja Welsch, Harald Schwalbe, Hartmut Michel, Dirk Bald, Schara Safarian

Publikováno v: Proc Natl Acad Sci U S A
Grund, T N, Radloff, M, Wu, D, Goojani, H G, Witte, L F, Jösting, W, Buschmann, S, Müller, H, Elamri, I, Welsch, S, Schwalbe, H, Michel, H, Bald, D & Safarian, S 2021, ' Mechanistic and structural diversity between cytochrome bd isoforms of Escherichia coli ', Proceedings of the National Academy of Sciences of the United States of America, vol. 118, no. 50, e2114013118, pp. 1-11 . https://doi.org/10.1073/pnas.2114013118
Proceedings of the National Academy of Sciences of the United States of America, 118(50):e2114013118, 1-11. National Acad Sciences

The treatment of infectious diseases caused by multidrug-resistant pathogens is a major clinical challenge of the 21st century. The membrane-embedded respiratory cytochrome bd-type oxygen reductase is a critical survival factor utilized by pathogenic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0de252d5310ee8dcb6dcd02ad792aac
https://research.vu.nl/en/publications/d0f38fc9-8303-4667-aa17-1eaaba36046b