Výsledky vyhledávání - "Hartmut, Koeppen"

Akademický článek

CEA-CD3 bispecific antibody cibisatamab with or without atezolizumab in patients with CEA-positive solid tumours: results of two multi-institutional Phase 1 trials

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)

Abstract Cibisatamab is a bispecific antibody-based construct targeting carcinoembryonic antigen (CEA) on tumour cells and CD3 epsilon chain as a T-cell engager. Here we evaluated cibisatamab for advanced CEA-positive solid tumours in two open-label

Externí odkaz: https://doaj.org/article/c7ab25df143a4df7a0b711f295ef7d2c

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Akademický článek

Selective PROTAC-mediated degradation of SMARCA2 is efficacious in SMARCA4 mutant cancers

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)

SMARCA2 has been identified as a synthetic lethal target in SMARCA4 mutated tumors, however, homology between the two has hindered the development of selective SMARCA2 inhibitors. Here, the authors synthesize a proteolysis targeting chimera (PROTAC)

Externí odkaz: https://doaj.org/article/8a0e9dc628914f238a2a801adba2571a

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Akademický článek

Distinct resistance mechanisms arise to allosteric vs. ATP-competitive AKT inhibitors

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)

How resistance to different classes of AKT inhibitors can emerge is unclear. Here, the authors show that resistance to allosteric inhibitors is mainly due to mutation of AKT1 while the ATP competitive resistance is driven by activation of PIM kinases

Externí odkaz: https://doaj.org/article/942eedd4f9f14214ba862fbc21b1991f

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Akademický článek

Decoding non-canonical mRNA decay by the endoplasmic-reticulum stress sensor IRE1α

Autor: Adrien Le Thomas, Elena Ferri, Scot Marsters, Jonathan M. Harnoss, David A. Lawrence, Iratxe Zuazo-Gaztelu, Zora Modrusan, Sara Chan, Margaret Solon, Cécile Chalouni, Weihan Li, Hartmut Koeppen, Joachim Rudolph, Weiru Wang, Thomas D. Wu, Peter Walter, Avi Ashkenazi

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

IRE1 helps mitigate endoplasmic-reticulum stress by cleaving specific mRNAs at a conserved sequence endomotif via regulated IRE1-dependent decay (RIDD). Here the authors discover a more promiscuous IRE1 activity dubbed RIDD lacking endomotif (RIDDLE)

Externí odkaz: https://doaj.org/article/bef46ea29dad4d2bbd29966c9a96665b

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Akademický článek

Integrated digital pathology and transcriptome analysis identifies molecular mediators of T-cell exclusion in ovarian cancer

Autor: Mélanie Desbois, Akshata R. Udyavar, Lisa Ryner, Cleopatra Kozlowski, Yinghui Guan, Milena Dürrbaum, Shan Lu, Jean-Philippe Fortin, Hartmut Koeppen, James Ziai, Ching-Wei Chang, Shilpa Keerthivasan, Marie Plante, Richard Bourgon, Carlos Bais, Priti Hegde, Anneleen Daemen, Shannon Turley, Yulei Wang

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)

The exclusion of T cells from solid tumours is a potentially important mechanism that regulates whether or not cancer patients respond well to checkpoint blocking immunotherapies. Here the authors identify immune phenotypes and mediators of T cell ex

Externí odkaz: https://doaj.org/article/e31d51185c324442b45c5107128325ef

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Akademický článek

Intratumoral CD103+ CD8+ T cells predict response to PD-L1 blockade

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 4 (2021)

Background CD8+ tissue-resident memory T (TRM) cells, marked by CD103 (ITGAE) expression, are thought to actively suppress cancer progression, leading to the hypothesis that their presence in tumors may predict response to immunotherapy.Methods Here,

Externí odkaz: https://doaj.org/article/ccc1e210948b41af9f921790f0cfde0d

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Akademický článek

Tumour and host cell PD-L1 is required to mediate suppression of anti-tumour immunity in mice

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)

PD-L1, the ligand for T-cell inhibitory receptor PD-1, can be expressed by various cell types in the tumour microenvironment. Here, the authors show that, in mouse models, the expression of PD-L1 from both cancerous and normal host immune cells is im

Externí odkaz: https://doaj.org/article/1afbaeea25fd48089e499f52e8e8af6d

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Immune contexture of paediatric cancers

Autor: Meghna Das, Thakur, Carl J, Franz, Laura, Brennan, Jurriaan, Brouwer-Visser, Rachel, Tam, Konstanty, Korski, Hartmut, Koeppen, James, Ziai, Galina, Babitzki, Dominique, Ranchere-Vince, Alexandre, Vasiljevic, Frédérique, Dijoud, Perrine, Marec-Bérard, Isabelle, Rochet, Michael A, Cannarile, Aurélien, Marabelle

Publikováno v: European Journal of Cancer. 170:179-193

The clinical development of immune checkpoint-targeted immunotherapies has been disappointing so far in paediatric solid tumours. However, as opposed to adults, very little is known about the immune contexture of paediatric malignancies.We investigat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b5c58d3a040b268045f4a933669361f
https://doi.org/10.1016/j.ejca.2022.03.012

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