Zobrazeno 1 - 10
of 493
pro vyhledávání: '"Hartmut, Jaeschke"'
Autor:
Xiaojuan Chao, Mengwei Niu, Shaogui Wang, Xiaowen Ma, Xiao Yang, Hua Sun, Xujia Hu, Hua Wang, Li Zhang, Ruili Huang, Menghang Xia, Andrea Ballabio, Hartmut Jaeschke, Hong-Min Ni, Wen-Xing Ding
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 1, Pp 190-206 (2024)
Macroautophagy (referred to as autophagy hereafter) is a major intracellular lysosomal degradation pathway that is responsible for the degradation of misfolded/damaged proteins and organelles. Previous studies showed that autophagy protects against a
Externí odkaz:
https://doaj.org/article/4b0c2a33eb9b4262a2b3fc740c55ae0b
Autor:
Giselle Sanchez-Guerrero, David S. Umbaugh, Abhay A. Ramachandran, Antonio Artigues, Hartmut Jaeschke, Anup Ramachandran
Publikováno v:
Livers, Vol 4, Iss 1, Pp 15-30 (2023)
The adenosine A2B receptor (A2BAR) is a member of a family of G-protein coupled receptors (GPCRs), which has a low affinity for adenosine and is now implicated in several pathophysiological conditions. We have demonstrated the beneficial effects of A
Externí odkaz:
https://doaj.org/article/ceb664350c874129ba3fca2decf832c9
Autor:
Anup Ramachandran, Hartmut Jaeschke
Publikováno v:
Livers, Vol 3, Iss 2, Pp 219-231 (2023)
Mitochondria are critical organelles responsible for the maintenance of cellular energy homeostasis. Thus, their dysfunction can have severe consequences in cells responsible for energy-intensive metabolic function, such as hepatocytes. Extensive res
Externí odkaz:
https://doaj.org/article/9d79a28a9e934ec2bffd5f11d8c02718
Publikováno v:
Livers, Vol 2, Iss 4, Pp 425-435 (2022)
Acetaminophen (APAP) is a widely used pain reliever that can cause liver injury or liver failure in response to an overdose. Understanding the mechanisms of APAP-induced cell death is critical for identifying new therapeutic targets. In this respect
Externí odkaz:
https://doaj.org/article/7c1cae44c9c84f8198c922efeb97c038
Autor:
Dakota R. Robarts, Steven R. McGreal, David S. Umbaugh, Wendena S. Parkes, Manasi Kotulkar, Sarah Abernathy, Norman Lee, Hartmut Jaeschke, Sumedha Gunewardena, Stephen A. Whelan, John A. Hanover, Natasha E. Zachara, Chad Slawson, Udayan Apte
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 5, Pp 1510-1529 (2022)
Background & Aims: The liver has a unique capacity to regenerate after injury in a highly orchestrated and regulated manner. Here, we report that O-GlcNAcylation, an intracellular post-translational modification regulated by 2 enzymes, O-GlcNAc trans
Externí odkaz:
https://doaj.org/article/ea3c4596c6654707b658a0f0be83e403
Autor:
Hartmut Jaeschke, Anup Ramachandran
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 1 (2023)
Externí odkaz:
https://doaj.org/article/50dff462041c42e2b18b7ea2e103e87b
Autor:
Hartmut Jaeschke, Olamide B. Adelusi, Jephte Y. Akakpo, Nga T. Nguyen, Giselle Sanchez-Guerrero, David S. Umbaugh, Wen-Xing Ding, Anup Ramachandran
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3740-3755 (2021)
Acetaminophen (APAP) is a widely used analgesic and antipyretic drug, which is safe at therapeutic doses but can cause severe liver injury and even liver failure after overdoses. The mouse model of APAP hepatotoxicity recapitulates closely the human
Externí odkaz:
https://doaj.org/article/bd69267488f147738d37afb49958d353
Autor:
Hui Qian, Qingyun Bai, Xiao Yang, Jephte Y. Akakpo, Lili Ji, Li Yang, Thomas Rülicke, Kurt Zatloukal, Hartmut Jaeschke, Hong-Min Ni, Wen-Xing Ding
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3791-3805 (2021)
Acetaminophen (APAP) overdose can induce liver injury and is the most frequent cause of acute liver failure in the United States. We investigated the role of p62/SQSTM1 (referred to as p62) in APAP-induced liver injury (AILI) in mice. We found that t
Externí odkaz:
https://doaj.org/article/11c1a25a9fed4671869e8d06a1fde45d
Autor:
Hartmut Jaeschke
Publikováno v:
Livers, Vol 2, Iss 3, Pp 105-107 (2022)
Acetaminophen (N-acetyl-para-aminophenol (APAP)) is one of the most-studied drugs worldwide [...]
Externí odkaz:
https://doaj.org/article/e479136e666d44038719a721ab27a053
Autor:
Ranjeet S. Kalsi, Alina Ostrowska, Adam Olson, Mubina Quader, Melvin Deutsch, Norma J. Arbujas-Silva, Jen Symmonds, Alejandro Soto-Gutierrez, John J. Crowley, Miguel Reyes-Mugica, Giselle Sanchez-Guerrero, Hartmut Jaeschke, Bruce P. Amiot, Marilia Cascalho, Scott L. Nyberg, Jeffrey L. Platt, Edgar N. Tafaleng, Ira J. Fox
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
Acute hepatic failure is associated with high morbidity and mortality for which the only definitive therapy is liver transplantation. Some fraction of those who undergo emergency transplantation have been shown to recover native liver function when t
Externí odkaz:
https://doaj.org/article/4a6dde84b6564e42889da8c6dbe04394