Zobrazeno 1 - 10
of 235
pro vyhledávání: '"Hartmut, Geiger"'
Autor:
Sara Montserrat-Vazquez, Noelle J. Ali, Francesca Matteini, Javier Lozano, Tu Zhaowei, Eva Mejia-Ramirez, Gina Marka, Angelika Vollmer, Karin Soller, Mehmet Sacma, Vadim Sakk, Loris Mularoni, Jan Philipp Mallm, Mireya Plass, Yi Zheng, Hartmut Geiger, M. Carolina Florian
Publikováno v:
npj Regenerative Medicine, Vol 7, Iss 1, Pp 1-17 (2022)
Abstract One goal of regenerative medicine is to rejuvenate tissues and extend lifespan by restoring the function of endogenous aged stem cells. However, evidence that somatic stem cells can be targeted in vivo to extend lifespan is still lacking. He
Externí odkaz:
https://doaj.org/article/a4bb8c5a146d41029eb29433f0022be5
Autor:
Cuiping Zhang, Xiaojing Cui, Yi Liu, Fang Wang, Robert Signer, Kapana Nattamai, Daohong Zhou, Yi Zheng, Hartmut Geiger, Fengyi Wan, Ying Liang
Publikováno v:
Haematologica, Vol 108, Iss 12 (2023)
Externí odkaz:
https://doaj.org/article/7306213419db47d5a4b95623dd5f3604
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Aging of mice can be tracked by DNA methylation changes at specific sites in the genome. In this study, we used the recently released Infinium Mouse Methylation BeadChip to compare such epigenetic modifications in C57BL/6 (B6) and DBA/2J (DBA) mice.
Externí odkaz:
https://doaj.org/article/a0bfefb01b12498cafaf7056008f853c
Autor:
Julian D. Schwab, Nensi Ikonomi, Silke D. Werle, Felix M. Weidner, Hartmut Geiger, Hans A. Kestler
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 5321-5332 (2021)
Regulatory dependencies in molecular networks are the basis of dynamic behaviors affecting the phenotypical landscape. With the advance of high throughput technologies, the detail of omics data has arrived at the single-cell level. Nevertheless, new
Externí odkaz:
https://doaj.org/article/02ac09438f424fe7b43b675397ba34ea
Autor:
Yang Han, Miloš Nikolić, Michael Gobs, Julia Franzen, Gerald de Haan, Hartmut Geiger, Wolfgang Wagner
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Abstract Age-associated DNA methylation reflects aspect of biological aging—therefore epigenetic clocks for mice can elucidate how the aging process in this model organism is affected by specific treatments or genetic background. Initially, age-pre
Externí odkaz:
https://doaj.org/article/3775f630f6454da794ff215f2b0461c3
Immunological history governs human stem cell memory CD4 heterogeneity via the Wnt signaling pathway
Autor:
Hassen Kared, Shu Wen Tan, Mai Chan Lau, Marion Chevrier, Crystal Tan, Wilson How, Glenn Wong, Marie Strickland, Benoit Malleret, Amanda Amoah, Karolina Pilipow, Veronica Zanon, Naomi Mc Govern, Josephine Lum, Jin Miao Chen, Bernett Lee, Maria Carolina Florian, Hartmut Geiger, Florent Ginhoux, Ezequiel Ruiz-Mateos, Tamas Fulop, Reena Rajasuriar, Adeeba Kamarulzaman, Tze Pin Ng, Enrico Lugli, Anis Larbi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Aging is associated with immune attrition that may impact the effectiveness of the immune system to protect the host from pathogens. Here the authors show that immune aging is associated with alterations in the Wnt/β-catenin signaling and reduced st
Externí odkaz:
https://doaj.org/article/d05913b802064e6bbba5a639e2f712a7
Autor:
Tanja Schuster, Hartmut Geiger
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Septins were first described in yeast. Due to extensive research in non-yeast cells, Septins are now recognized across all species as important players in the regulation of the cytoskeleton, in the establishment of polarity, for migration, vesicular
Externí odkaz:
https://doaj.org/article/767abd5f372e4e85bf75a4f86d63a3bf
Publikováno v:
iScience, Vol 24, Iss 4, Pp 102362- (2021)
Summary: Homeostasis in the intestinal epithelium is maintained by Lgr5-positive intestinal stem cells (ISCs) located at the base of the crypt. The function of ISCs is reduced upon aging which leads to a decline of regeneration of the intestinal epit
Externí odkaz:
https://doaj.org/article/95436dc61a1d4093bd1bee9e836db57a
Autor:
Juana Serrano-Lopez, Shailaja Hegde, Sachin Kumar, Josefina Serrano, Jing Fang, Ashley M Wellendorf, Paul A Roche, Yamileth Rangel, Leolene J Carrington, Hartmut Geiger, H Leighton Grimes, Sanjiv Luther, Ivan Maillard, Joaquin Sanchez-Garcia, Daniel T Starczynowski, Jose A Cancelas
Publikováno v:
eLife, Vol 10 (2021)
Innate immune cellular effectors are actively consumed during systemic inflammation, but the systemic traffic and the mechanisms that support their replenishment remain unknown. Here, we demonstrate that acute systemic inflammation induces the emerge
Externí odkaz:
https://doaj.org/article/08b4f0f9fe184ce5b3fbfcccc7aca175
Autor:
Yossi Ovadya, Tomer Landsberger, Hanna Leins, Ezra Vadai, Hilah Gal, Anat Biran, Reut Yosef, Adi Sagiv, Amit Agrawal, Alon Shapira, Joseph Windheim, Michael Tsoory, Reinhold Schirmbeck, Ido Amit, Hartmut Geiger, Valery Krizhanovsky
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Senescent cells accumulate with aging contributing to age-related disease and the role of the immune system in removing senescent cells is not completely understood. Here, the authors show that perforin deficient mice accumulate more senescent cells
Externí odkaz:
https://doaj.org/article/a1ec80e65b354c269b44d215e404c1cc