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Favorable Antiviral Effect of Metformin on SARS-CoV-2 Viral Load in a Randomized, Placebo-Controlled Clinical Trial of COVID-19.

Autor: Bramante CT; General Internal Medicine, University of Minnesota, Minneapolis, Minnesota, USA., Beckman KB; Genomics Center, University of Minnesota, Minneapolis, Minnesota, USA., Mehta T; Division of Biostatistics and Health Data Science, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA., Karger AB; Department of Laboratory Medicine and Pathology, Medical School, University of Minnesota, Minneapolis, Minnesota, USA., Odde DJ; Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota, USA., Tignanelli CJ; Department of Surgery, Medical School, University of Minnesota, Minneapolis, Minnesota, USA., Buse JB; Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA., Johnson DM; Genomics Center, University of Minnesota, Minneapolis, Minnesota, USA., Watson RHB; Genomics Center, University of Minnesota, Minneapolis, Minnesota, USA., Daniel JJ; Genomics Center, University of Minnesota, Minneapolis, Minnesota, USA., Liebovitz DM; General Internal Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Nicklas JM; General Internal Medicine, University of Colorado, School of Medicine, Aurora, Colorado, USA., Cohen K; UnitedHealth Group, Optum Labs, Minnetonka, Minnesota, USA., Puskarich MA; Emergency Medicine, Hennepin County Medical Center, Minneapolis, Minnesota, USA., Belani HK; Department of Medicine, Olive View-University of California, Los Angeles, California, USA., Siegel LK; Division of Biostatistics and Health Data Science, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA., Klatt NR; Department of Surgery, Medical School, University of Minnesota, Minneapolis, Minnesota, USA., Anderson B; Atlanta Veterans Affairs Medical Center, Atlanta, Georgia, USA.; Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA., Hartman KM; General Internal Medicine, University of Minnesota, Minneapolis, Minnesota, USA., Rao V; General Internal Medicine, University of Minnesota, Minneapolis, Minnesota, USA., Hagen AA; General Internal Medicine, University of Minnesota, Minneapolis, Minnesota, USA., Patel B; General Internal Medicine, University of Minnesota, Minneapolis, Minnesota, USA., Fenno SL; General Internal Medicine, University of Minnesota, Minneapolis, Minnesota, USA., Avula N; General Internal Medicine, University of Minnesota, Minneapolis, Minnesota, USA., Reddy NV; General Internal Medicine, University of Minnesota, Minneapolis, Minnesota, USA., Erickson SM; General Internal Medicine, University of Minnesota, Minneapolis, Minnesota, USA., Fricton RD; General Internal Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Lee S; General Internal Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Griffiths G; General Internal Medicine, University of Minnesota, Minneapolis, Minnesota, USA., Pullen MF; Division of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA., Thompson JL; Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Sherwood NE; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA., Murray TA; Division of Biostatistics and Health Data Science, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA., Rose MR; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Boulware DR; Division of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA., Huling JD; Division of Biostatistics and Health Data Science, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA.

Publikováno v: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2024 Aug 16; Vol. 79 (2), pp. 354-363.

Strategies used for the COVID-OUT decentralized trial of outpatient treatment of SARS-CoV-2.

Autor: Avula N; Department of Medicine, Medical School, University of Minnesota, Minneapolis, MN, USA., Kakach D; Investigational Drug Service, Fairview Health Services, University of Minnesota Medical Center, Minneapolis, MN, USA., Tignanelli CJ; Department of Surgery, Medical School, University of Minnesota, Minneapolis, MN, USA., Liebovitz DM; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Nicklas JM; Department of Medicine, School of Medicine, University of Colorado-Anschutz Medical Campus, Aurora, CO, USA., Cohen K; UnitedHealth Group, Optum Health, Minnetonka, MN, USA., Puskarich MA; Department of Emergency Medicine, School of Medicine, University of Minnesota, Minneapolis, MN, USA.; Department of Emergency Medicine, Hennepin County Medical Center, Minneapolis, MN, USA., Belani HK; Department of Medicine, Olive View - University of California, Los Angeles, CA, USA., Buse JB; Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC, USA., Klatt NR; Department of Surgery, Medical School, University of Minnesota, Minneapolis, MN, USA., Anderson B; Atlanta Veterans Affairs Medical Center and the Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA., Karger AB; Department of Laboratory Medicine and Pathology, Medical School, University of Minnesota, Minneapolis, MN, USA., Hartman KM; Department of Medicine, Medical School, University of Minnesota, Minneapolis, MN, USA., Patel B; Department of Medicine, Medical School, University of Minnesota, Minneapolis, MN, USA., Fenno SL; Department of Medicine, Medical School, University of Minnesota, Minneapolis, MN, USA., Reddy NV; Department of Medicine, Medical School, University of Minnesota, Minneapolis, MN, USA., Erickson SM; Department of Medicine, Medical School, University of Minnesota, Minneapolis, MN, USA., Boulware DR; Department of Medicine, Medical School, University of Minnesota, Minneapolis, MN, USA., Murray TA; Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, USA., Bramante CT; Department of Medicine, Medical School, University of Minnesota, Minneapolis, MN, USA.

Publikováno v: Journal of clinical and translational science [J Clin Transl Sci] 2023 Nov 07; Vol. 7 (1), pp. e242. Date of Electronic Publication: 2023 Nov 07 (Print Publication: 2023).

Metformin reduces SARS-CoV-2 in a Phase 3 Randomized Placebo Controlled Clinical Trial.

Autor: Bramante CT; General Internal Medicine, University of Minnesota, Minneapolis, MN., Beckman KB; Genomics Center, University of Minnesota, Minneapolis, MN., Mehta T; Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN., Karger AB; Department of Laboratory Medicine and Pathology, Medical School, University of Minnesota, Minneapolis, MN., Odde DJ; Department of Biomedical Engineering University of Minnesota, Minneapolis, MN., Tignanelli CJ; Department of Surgery, Medical School, University of Minnesota, Minneapolis, MN., Buse JB; Endocrinology, University of North Carolina, Chapel Hill, NC., Johnson DM; Genomics Center, University of Minnesota, Minneapolis, MN., Watson RHB; Genomics Center, University of Minnesota, Minneapolis, MN., Daniel JJ; Genomics Center, University of Minnesota, Minneapolis, MN., Liebovitz DM; General Internal Medicine, Northwestern University, Chicago, IL., Nicklas JM; General Internal Medicine, University of Colorado, Denver, CO., Cohen K; UnitedHealth Group, Optum Labs, Minnetonka, MN., Puskarich MA; Emergency Medicine, Hennepin County Medical Center, Minneapolis, MN., Belani HK; Department of Medicine, Olive View - University of California, Los Angeles, CA., Siegel LK; Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN., Klatt NR; Department of Surgery, Medical School, University of Minnesota, Minneapolis, MN., Anderson B; Atlanta Veterans Affairs Medical Center, Atlanta, Georgia; Department of Medicine, Emory University School of Medicine, Atlanta, GA., Hartman KM; General Internal Medicine, University of Minnesota, Minneapolis, MN., Rao V; General Internal Medicine, University of Minnesota, Minneapolis, MN., Hagen AA; General Internal Medicine, University of Minnesota, Minneapolis, MN., Patel B; General Internal Medicine, University of Minnesota, Minneapolis, MN., Fenno SL; General Internal Medicine, University of Minnesota, Minneapolis, MN., Avula N; General Internal Medicine, University of Minnesota, Minneapolis, MN., Reddy NV; General Internal Medicine, University of Minnesota, Minneapolis, MN., Erickson SM; General Internal Medicine, University of Minnesota, Minneapolis, MN., Fricton RD; General Internal Medicine, Northwestern University, Chicago, IL., Lee S; General Internal Medicine, Northwestern University, Chicago, IL., Griffiths G; General Internal Medicine, University of Minnesota, Minneapolis, MN., Pullen MF; Division of Infectious Diseases and International Medicine, University of Minnesota, Minneapolis, MN., Thompson JL; Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, TN., Sherwood N; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN., Murray TA; Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN., Rose MR; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN., Boulware DR; Division of Infectious Diseases and International Medicine, University of Minnesota, Minneapolis, MN., Huling JD; Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2023 Jun 07. Date of Electronic Publication: 2023 Jun 07.