A yeast phenomic model for the influence of Warburg metabolism on genetic buffering of doxorubicin

Autor: Santos, Sean M, Hartman IV, John L

Publikováno v: Cancer & Metabolism, Vol 7, Iss 1, Pp 1-42 (2019)
Cancer & Metabolism

BackgroundSaccharomyces cerevisiaerepresses respiration in the presence of adequate glucose, mimicking the Warburg effect, termed aerobic glycolysis. We conducted yeast phenomic experiments to characterize differential doxorubicin-gene interaction, i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2944d7d05e239804b7a52ff2929f9d7c
https://doi.org/10.1101/517490

Global analysis of phase locking in gene expression during cell cycle: the potential in network modeling.

Autor: Gao, Shouguo^1,2, Hartman, IV, John L.³, Carter, Justin L.¹, Hessner, Martin J.^4,5, Xujing Wang^1,2 xujingw@uab.edu

Publikováno v: BMC Systems Biology. 2010, Vol. 4, p167-182. 16p.

A yeast phenomic model for the gene interaction network modulating F508del-CFTR protein biogenesis

Autor: Louie, Raymond J, Guo, Jingyu, Rodgers, John W, White, Rick, Shah, Najaf A, Pagant, Silvere, Kim, Peter, Livstone, Michael, Dolinski, Kara, McKinney, Brett A, Hong, Jeong, Sorscher, Eric J, Bryan, Jennifer, Miller, Elizabeth A, Hartman IV, John L

Publikováno v: Louie, Raymond J; Guo, Jingyu; Rodgers, John W; White, Rick; Shah, Najaf A; Pagant, Silvere; et al.(2012). A yeast phenomic model for the gene interaction network modulating F508del-CFTR protein biogenesis. Genome Medicine, 4(12), 103. doi: http://dx.doi.org/10.1186/gm404. Retrieved from: http://www.escholarship.org/uc/item/6nj337r3

Background The overall influence of gene interaction in human disease is unknown. In cystic fibrosis (CF) a single allele of the cystic fibrosis transmembrane conductance regulator (CFTR-ΔF508) accounts for most of the disease. In cell models, CFTR-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::ec1af707ddda4a04dab322c32899b6a3
http://www.escholarship.org/uc/item/6nj337r3

Long-range coupling between the extracellular gates and the intracellular ATP binding domains of multidrug resistance protein pumps and cystic fibrosis transmembrane conductance regulator channels.

Autor: Shipeng Wei, Roessler, Bryan C., Icyuz, Mert, Chauvet, Sylvain, Binli Tao, Hartman IV, John L., Kirk, Kevin L.

Publikováno v: FASEB Journal; Mar2016, Vol. 30 Issue 3, p1247-1262, 16p

The SWI/SNF Chromatin Remodeling Complex Influences Transcription by RNA Polymerase I in Saccharomyces cerevisiae.

Autor: Zhang, Yinfeng, Anderson, Susan J., French, Sarah L., Sikes, Martha L., Viktorovskaya, Olga V., Huband, Jacalyn, Holcomb, Katherine, Hartman IV, John L., Beyer, Ann L., Schneider, David A.

Publikováno v: PLoS ONE; Feb2013, Vol. 8 Issue 2, p1-11, 11p