Atherosclerotic Plaque Epigenetic Age Acceleration Predicts a Poor Prognosis and Is Associated With Endothelial-to-Mesenchymal Transition in Humans.

Autor: Diez Benavente, Ernest, Hartman, Robin J. G., Sakkers, Tim R., Wesseling, Marian, Sloots, Yannicke, Slenders, Lotte, Boltjes, Arjan, Mol, Barend M., de Borst, Gert J., de Kleijn, Dominique P. V., Prange, Koen H. M., de Winther, Menno P. J., Kuiper, Johan, Civelek, Mete, van der Laan, Sander W., Horvath, Steve, Onland-Moret, N. Charlotte, Mokry, Michal, Pasterkamp, Gerard, den Ruijter, Hester M.

Publikováno v: Arteriosclerosis, Thrombosis & Vascular Biology; Jun2024, Vol. 44 Issue 6, p1419-1431, 13p

Female Gene Networks Are Expressed in Myofibroblast-Like Smooth Muscle Cells in Vulnerable Atherosclerotic Plaques.

Autor: Diez Benavente, Ernest, Karnewar, Santosh, Buono, Michele, Mili, Eloi, Hartman, Robin J. G., Kapteijn, Daniek, Slenders, Lotte, Daniels, Mark, Aherrahrou, Redouane, Reinberger, Tobias, Mol, Barend M., de Borst, Gert J., de Kleijn, Dominique P. V., Prange, Koen H. M., Depuydt, Marie A. C., de Winther, Menno P. J., Kuiper, Johan, Björkegren, Johan L. M., Erdmann, Jeanette, Civelek, Mete

Publikováno v: Arteriosclerosis, Thrombosis & Vascular Biology; Oct2023, Vol. 43 Issue 10, p1836-1850, 15p

Sex-Stratified Gene Regulatory Networks Reveal Female Key Driver Genes of Atherosclerosis Involved in Smooth Muscle Cell Phenotype Switching.

Autor: Hartman, Robin J. G., Owsiany, Katie, Lijiang Ma, Koplev, Simon, Ke Hao, Slenders, Lotte, Civelek, Mete, Mokry, Michal, Kovacic, Jason C., Pasterkamp, Gerard, Owens, Gary, Björkegren, Johan L. M., den Ruijter, Hester M., Ma, Lijiang, Hao, Ke

Publikováno v: Circulation; 2/16/2021, Vol. 143 Issue 7, p713-726, 14p

Long noncoding RNA VENTHEART is required for ventricular cardiomyocyte specification and function.

Autor: Yang Y; Cardiovascular Metabolic Disease Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Cardiovascular Research Institute, National University Healthcare Systems, Singapore; NUS Graduate School, National University of Singapore, Singapore., Dashi A; Cardiovascular Metabolic Disease Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Cardiovascular Research Institute, National University Healthcare Systems, Singapore., Soong PL; Cardiovascular Metabolic Disease Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Cardiovascular Research Institute, National University Healthcare Systems, Singapore; Ternion Biosciences, Singapore., Lin KH; Ternion Biosciences, Singapore., Tan WLW; Cardiovascular Metabolic Disease Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Cardiovascular Research Institute, National University Healthcare Systems, Singapore., Pan B; Cardiovascular Metabolic Disease Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Cardiovascular Research Institute, National University Healthcare Systems, Singapore., Autio MI; Cardiovascular Metabolic Disease Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Cardiovascular Research Institute, National University Healthcare Systems, Singapore; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore., Tiang Z; Cardiovascular Metabolic Disease Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Cardiovascular Research Institute, National University Healthcare Systems, Singapore., Hartman RJG; University of Utrecht, Heidelberglaan 8, 3584 CS Utrecht, the Netherlands; Translational Science & Experimental Medicine, Early Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Wei H; National Heart Research Institute Singapore (NHRIS), National Heart Centre, Singapore., Ackers-Johnson MA; Cardiovascular Metabolic Disease Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Cardiovascular Research Institute, National University Healthcare Systems, Singapore., Lim B; Sana Biotechnology, 300 Technology Square, Cambridge, MA 02139, United States of America., Walentinsson A; Translational Science & Experimental Medicine, Early Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Iyer VV; Bioscience Cardiovascular, Early Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden; Uppsala University, Uppsala, Sweden., Jonsson MKB; Cardiovascular Metabolic Disease Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Bioscience Cardiovascular, Early Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Foo RS; Cardiovascular Metabolic Disease Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Cardiovascular Research Institute, National University Healthcare Systems, Singapore; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore. Electronic address: roger.foo@nus.edu.sg.

Publikováno v: Journal of molecular and cellular cardiology [J Mol Cell Cardiol] 2024 Oct 25. Date of Electronic Publication: 2024 Oct 25.

Transcriptomic-based clustering of human atherosclerotic plaques identifies subgroups with different underlying biology and clinical presentation.

Autor: Mokry M; Central Diagnostics Laboratory, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands.; Laboratory of Experimental Cardiology, Department of Cardiology, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands., Boltjes A; Central Diagnostics Laboratory, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands., Slenders L; Central Diagnostics Laboratory, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands., Bel-Bordes G; Central Diagnostics Laboratory, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands., Cui K; Laboratory of Experimental Cardiology, Department of Cardiology, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands., Brouwer E; Central Diagnostics Laboratory, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands., Mekke JM; Department of Vascular Surgery, University Medical Centre Utrecht, Utrecht, The Netherlands., Depuydt MAC; Leiden Academic Centre for Drug Research, Division of Biotherapeutics, Leiden University, Leiden, The Netherlands., Timmerman N; Department of Vascular Surgery, University Medical Centre Utrecht, Utrecht, The Netherlands., Waissi F; Department of Vascular Surgery, University Medical Centre Utrecht, Utrecht, The Netherlands., Verwer MC; Department of Vascular Surgery, University Medical Centre Utrecht, Utrecht, The Netherlands., Turner AW; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA., Khan MD; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA., Hodonsky CJ; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA., Benavente ED; Laboratory of Experimental Cardiology, Department of Cardiology, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands., Hartman RJG; Laboratory of Experimental Cardiology, Department of Cardiology, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands., van den Dungen NAM; Central Diagnostics Laboratory, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands., Lansu N; Central Diagnostics Laboratory, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands., Nagyova E; Central Diagnostics Laboratory, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands., Prange KHM; Amsterdam University Medical Centers - location AMC, University of Amsterdam, Experimental Vascular Biology, Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, Amsterdam Infection and Immunity, Amsterdam, The Netherlands., Kovacic JC; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Victor Chang Cardiac Research Institute, Darlinghurst, Australia; and St Vincent's Clinical School, University of New South Wales, Australia., Björkegren JLM; Department of Medicine, Karolinska Institutet, Karolinska Universitetssjukhuset, Huddinge, Sweden.; Department of Genetics & Genomic Sciences, Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029-6574, USA., Pavlos E; Laboratory of Immunobiology, Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece., Andreakos E; Laboratory of Immunobiology, Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece., Schunkert H; Department of Cardiology, German Heart Centre Munich, Technical University of Munich, Munich, Germany.; German Centre for Cardiovascular Research (DZHK e.V.), Partner Site Munich Heart Alliance, Munich, Germany., Owens GK; Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA, USA.; Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, USA., Monaco C; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford., Finn AV; CVPath Institute, Inc, Gaithersburg, MD, USA., Virmani R; CVPath Institute, Inc, Gaithersburg, MD, USA., Leeper NJ; Department of Surgery, Division of Vascular Surgery, Stanford University School of Medicine, Stanford, CA., de Winther MPJ; Amsterdam University Medical Centers - location AMC, University of Amsterdam, Experimental Vascular Biology, Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, Amsterdam Infection and Immunity, Amsterdam, The Netherlands., Kuiper J; Leiden Academic Centre for Drug Research, Division of Biotherapeutics, Leiden University, Leiden, The Netherlands., de Borst GJ; Department of Vascular Surgery, University Medical Centre Utrecht, Utrecht, The Netherlands., Stroes ESG; Department of Vascular Medicine, Amsterdam University Medical Centers, Location AMC, Amsterdam, the Netherlands., Civelek M; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA., de Kleijn DPV; Department of Vascular Surgery, University Medical Centre Utrecht, Utrecht, The Netherlands., den Ruijter HM; Laboratory of Experimental Cardiology, Department of Cardiology, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands., Asselbergs FW; Department of Cardiology, Division Heart & Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.; Health Data Research UK and Institute of Health Informatics, University College London, London, United Kingdom., van der Laan SW; Central Diagnostics Laboratory, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands., Miller CL; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.; Department of Biomedical Engineering, Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, USA.; Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA., Pasterkamp G; Central Diagnostics Laboratory, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands.

Publikováno v: Nature cardiovascular research [Nat Cardiovasc Res] 2022 Dec; Vol. 1 (12), pp. 1140-1155. Date of Electronic Publication: 2022 Dec 12.