Restoring thalamocortical circuit dysfunction by correcting HCN channelopathy in Shank3 mutant mice.

Autor: Guo B; Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an 710032, China; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Liu T; School of Biomedical Engineering and Technology, Tianjin Medical University, Tianjin 300070, China., Choi S; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, MIT, Cambridge, MA 02139, USA., Mao H; Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an 710032, China., Wang W; Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an 710032, China., Xi K; Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an 710032, China., Jones C; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Hartley ND; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, MIT, Cambridge, MA 02139, USA., Feng D; Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an 710032, China., Chen Q; McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, MIT, Cambridge, MA 02139, USA., Liu Y; Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an 710032, China., Wimmer RD; McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, MIT, Cambridge, MA 02139, USA., Xie Y; Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an 710032, China., Zhao N; Xi'an TCM Hospital of Encephalopathy, Shaanxi University of Chinese Medicine, Xi'an 710032, China., Ou J; Department of Psychiatry, The Second Xiangya Hospital of Central South University, National Clinical Research Center for Mental Disorders, Changsha 410011, China., Arias-Garcia MA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Malhotra D; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Liu Y; Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an 710032, China., Lee S; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Pasqualoni S; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Kast RJ; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, MIT, Cambridge, MA 02139, USA., Fleishman M; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Halassa MM; McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, MIT, Cambridge, MA 02139, USA., Wu S; Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an 710032, China. Electronic address: shengxi@fmmu.edu.cn., Fu Z; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, MIT, Cambridge, MA 02139, USA. Electronic address: zfu@broadinstitute.org.

Publikováno v: Cell reports. Medicine [Cell Rep Med] 2024 May 21; Vol. 5 (5), pp. 101534. Date of Electronic Publication: 2024 Apr 25.

CB1R dysfunction of inhibitory synapses in the ACC drives chronic social isolation stress-induced social impairments in male mice.

Autor: Guo B; Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an 710032, China. Electronic address: baolguo@fmmu.edu.cn., Xi K; Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an 710032, China., Mao H; Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an 710032, China., Ren K; Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an 710032, China., Xiao H; Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an 710032, China., Hartley ND; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; McGovern Institute for Brain Research in the Department of Brain and Cognitive Sciences at MIT, Cambridge, MA 02139, USA., Zhang Y; Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an 710032, China., Kang J; Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an 710032, China., Liu Y; Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an 710032, China., Xie Y; Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an 710032, China., Zhou Y; Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an 710032, China., Zhu Y; Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an 710032, China., Zhang X; Department of Neurology, West China Hospital, Sichuan University, Chengdu 610041, China., Fu Z; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; McGovern Institute for Brain Research in the Department of Brain and Cognitive Sciences at MIT, Cambridge, MA 02139, USA., Chen JF; State Key Laboratory of Ophthalmology, Optometry and Vision Science, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China., Hu H; School of Brain Science and Brain Medicine, New Cornerstone Science Laboratory, Zhejiang University School of Medicine, Hangzhou 310058, China., Wang W; Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an 710032, China. Electronic address: wwt0657@fmmu.edu.cn., Wu S; Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an 710032, China. Electronic address: shengxi@fmmu.edu.cn.

Publikováno v: Neuron [Neuron] 2024 Feb 07; Vol. 112 (3), pp. 441-457.e6. Date of Electronic Publication: 2023 Nov 21.

An endocannabinoid-regulated basolateral amygdala-nucleus accumbens circuit modulates sociability.

Autor: Folkes OM; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Pharmacology and., Báldi R; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Kondev V; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Vanderbilt Brain Institute, Vanderbilt University School of Medicine, Nashville, Tennessee, USA., Marcus DJ; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Vanderbilt Brain Institute, Vanderbilt University School of Medicine, Nashville, Tennessee, USA., Hartley ND; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Vanderbilt Brain Institute, Vanderbilt University School of Medicine, Nashville, Tennessee, USA., Turner BD; Vanderbilt Brain Institute, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.; Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Ayers JK; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Baechle JJ; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Misra MP; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Altemus M; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Grueter CA; Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Grueter BA; Vanderbilt Brain Institute, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.; Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Patel S; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Pharmacology and.; Vanderbilt Brain Institute, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.; Vanderbilt Center for Addiction Research, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2020 Apr 01; Vol. 130 (4), pp. 1728-1742.

Functional Redundancy Between Canonical Endocannabinoid Signaling Systems in the Modulation of Anxiety.

Autor: Bedse G; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee., Hartley ND; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Vanderbilt Brain Institute, Vanderbilt University School of Medicine, Nashville, Tennessee., Neale E; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee., Gaulden AD; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee., Patrick TA; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee., Kingsley PJ; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee; Department of Chemistry, Vanderbilt University School of Medicine, Nashville, Tennessee; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee; Department of A.B. Hancock Jr. Memorial Laboratory for Cancer Research, Vanderbilt University School of Medicine, Nashville, Tennessee; Department of Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine, Nashville, Tennessee., Uddin MJ; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee; Department of Chemistry, Vanderbilt University School of Medicine, Nashville, Tennessee; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee; Department of A.B. Hancock Jr. Memorial Laboratory for Cancer Research, Vanderbilt University School of Medicine, Nashville, Tennessee; Department of Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine, Nashville, Tennessee., Plath N; Department of H. Lundbeck A/S, Copenhagen, Denmark., Marnett LJ; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee; Department of Chemistry, Vanderbilt University School of Medicine, Nashville, Tennessee; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee; Department of A.B. Hancock Jr. Memorial Laboratory for Cancer Research, Vanderbilt University School of Medicine, Nashville, Tennessee; Department of Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine, Nashville, Tennessee., Patel S; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee. Electronic address: sachin.patel@vanderbilt.edu.

Publikováno v: Biological psychiatry [Biol Psychiatry] 2017 Oct 01; Vol. 82 (7), pp. 488-499. Date of Electronic Publication: 2017 Mar 15.

Endocannabinoid signalling modulates susceptibility to traumatic stress exposure.

Autor: Bluett RJ; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.; The Vanderbilt Brain Institute, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA., Báldi R; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA., Haymer A; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA., Gaulden AD; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA., Hartley ND; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.; The Vanderbilt Brain Institute, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA., Parrish WP; Department of Molecular Physiology &Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA., Baechle J; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA., Marcus DJ; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.; The Vanderbilt Brain Institute, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA., Mardam-Bey R; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA., Shonesy BC; Department of Molecular Physiology &Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA., Uddin MJ; A.B. Hancock Jr. Memorial Laboratory for Cancer Research and Vanderbilt Institute of Chemical Biology, Nashville, Tennessee 37232, USA., Marnett LJ; A.B. Hancock Jr. Memorial Laboratory for Cancer Research and Vanderbilt Institute of Chemical Biology, Nashville, Tennessee 37232, USA.; Departments of Biochemistry, Chemistry and Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA., Mackie K; Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana 47405, USA., Colbran RJ; The Vanderbilt Brain Institute, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.; Department of Molecular Physiology &Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.; Vanderbilt Kennedy Center for Human Development, Nashville, Tennessee 37232, USA.; Vanderbilt Center for Addiction Research, Vanderbilt University, Nashville, Tennessee 37232, USA., Winder DG; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.; The Vanderbilt Brain Institute, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.; Department of Molecular Physiology &Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.; Vanderbilt Kennedy Center for Human Development, Nashville, Tennessee 37232, USA.; Vanderbilt Center for Addiction Research, Vanderbilt University, Nashville, Tennessee 37232, USA., Patel S; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.; The Vanderbilt Brain Institute, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.; Department of Molecular Physiology &Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.; Vanderbilt Kennedy Center for Human Development, Nashville, Tennessee 37232, USA.; Vanderbilt Center for Addiction Research, Vanderbilt University, Nashville, Tennessee 37232, USA.

Publikováno v: Nature communications [Nat Commun] 2017 Mar 28; Vol. 8, pp. 14782. Date of Electronic Publication: 2017 Mar 28.