HOIL1 regulates group 2 innate lymphoid cell numbers and type 2 inflammation in the small intestine

Autor: Wood, Matthew J., Marshall, Jeffrey N., Hartley, Victoria L., Liu, Ta-Chiang, Iwai, Kazuhiro, Stappenbeck, Thaddeus S., MacDuff, Donna A.

Publikováno v: In Mucosal Immunology April 2022 15(4):642-655

Investigating the Role of HOIL1 in Controlling Citrobacter rodentium Pathogenesis

Autor: Hartley, Victoria L

HOIL1-deficient patients experience chronic intestinal inflammation and diarrhea as well as increased susceptibility to certain bacterial infections. HOIL1 is a component of the linear ubiquitin chain assembly complex (LUBAC) that regulates immune si

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HOIL1 Regulates Group 3 Innate Lymphoid Cells in the Colon and Protects against Systemic Dissemination, Colonic Ulceration, and Lethality from Citrobacter rodentium Infection.

Autor: Hartley VL; Department of Microbiology and Immunology, University of Illinois Chicago College of Medicine, Chicago, IL., Qaqish AM; Department of Microbiology and Immunology, University of Illinois Chicago College of Medicine, Chicago, IL., Wood MJ; Department of Microbiology and Immunology, University of Illinois Chicago College of Medicine, Chicago, IL., Studnicka BT; Department of Microbiology and Immunology, University of Illinois Chicago College of Medicine, Chicago, IL., Iwai K; Department of Molecular and Cellular Physiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Liu TC; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO., MacDuff DA; Department of Microbiology and Immunology, University of Illinois Chicago College of Medicine, Chicago, IL.

Publikováno v: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2023 Dec 15; Vol. 211 (12), pp. 1823-1834.