Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Hartland W. Jackson"'
Autor:
Dzana Dervovic, Ahmad A. Malik, Edward L. Y. Chen, Masahiro Narimatsu, Nina Adler, Somaieh Afiuni-Zadeh, Dagmar Krenbek, Sebastien Martinez, Ricky Tsai, Jonathan Boucher, Jacob M. Berman, Katie Teng, Arshad Ayyaz, YiQing Lü, Geraldine Mbamalu, Sampath K. Loganathan, Jongbok Lee, Li Zhang, Cynthia Guidos, Jeffrey Wrana, Arschang Valipour, Philippe P. Roux, Jüri Reimand, Hartland W. Jackson, Daniel Schramek
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract How the genetic landscape governs a tumor’s response to immunotherapy remains poorly understood. To assess the immune-modulatory capabilities of 573 genes associated with altered cytotoxicity in human cancers, here we perform CRISPR/Cas9 s
Externí odkaz:
https://doaj.org/article/e4b4d4a5470d43e0817e0d24ed7429c7
Autor:
Dzana Dervovic, Ahmad A. Malik, Edward L. Y. Chen, Masahiro Narimatsu, Nina Adler, Somaieh Afiuni-Zadeh, Dagmar Krenbek, Sebastien Martinez, Ricky Tsai, Jonathan Boucher, Jacob M. Berman, Katie Teng, Arshad Ayyaz, YiQing Lü, Geraldine Mbamalu, Sampath K. Loganathan, Jongbok Lee, Li Zhang, Cynthia Guidos, Jeffrey Wrana, Arschang Valipour, Philippe P. Roux, Jüri Reimand, Hartland W. Jackson, Daniel Schramek
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/2c37d159f9ad4586ac8c4e1cbb1c41af
Autor:
Purna A. Joshi, Paul D. Waterhouse, Nagarajan Kannan, Swami Narala, Hui Fang, Marco A. Di Grappa, Hartland W. Jackson, Josef M. Penninger, Connie Eaves, Rama Khokha
Publikováno v:
Stem Cell Reports, Vol 5, Iss 1, Pp 31-44 (2015)
Systemic and local signals must be integrated by mammary stem and progenitor cells to regulate their cyclic growth and turnover in the adult gland. Here, we show RANK-positive luminal progenitors exhibiting WNT pathway activation are selectively expa
Externí odkaz:
https://doaj.org/article/72bc6c94b5b0407bb71fd90f7b2fccfa
Autor:
Yu-Jia Shiah, Pirashaanthy Tharmapalan, Alison E. Casey, Purna A. Joshi, Trevor D. McKee, Hartland W. Jackson, Alexander G. Beristain, Michelle A. Chan-Seng-Yue, Gary D. Bader, John P. Lydon, Paul D. Waterhouse, Paul C. Boutros, Rama Khokha
Publikováno v:
Stem Cell Reports, Vol 4, Iss 3, Pp 313-322 (2015)
Progesterone drives mammary stem and progenitor cell dynamics through paracrine mechanisms that are currently not well understood. Here, we demonstrate that CXCR4, the receptor for stromal-derived factor 1 (SDF-1; CXC12), is a crucial instructor of h
Externí odkaz:
https://doaj.org/article/7ef44eb58c7349ed8180897fb814a2db
Autor:
Ruonan Cao, Nancy T. Li, Simon Latour, Jose L. Cadavid, Cassidy M. Tan, Ari Forman, Hartland W. Jackson, Alison P. McGuigan
Publikováno v:
Advanced Healthcare Materials.
Autor:
Daniel Schramek, Geoffrey M. Wahl, Miguel Angel Pujana, Erik S. Knudsen, Agnieszka K. Witkiewicz, Michael D. Wilson, Hartland W. Jackson, Jeffrey L. Wrana, Therese Sørlie, David W. Cescon, Sean E. Egan, Gary D. Bader, Rod Bremner, Sampath K. Loganathan, Seda Barutcu, Thomas Nguyen, Jeff C. Liu, Masahiro Narimatsu, Daniel Trcka, Katelyn J. Kozma, Robin H. Oh, YiQing Lü, Andrew Elia, Sana Alvi, Ricky Tsai, Somaieh Afiuni-Zadeh, Samah El Ghamrasni, Helga Bergholtz, Ahmad Malik, Katie Teng, Roderic Espin, Liis Uuskula-Reimand, Minggao Liang, Zhibo Ma, Khalid N. Al-Zahrani, Ellen Langille
Systematically investigating the scores of genes mutated in cancer and discerning disease drivers from inconsequential bystanders is a prerequisite for precision medicine but remains challenging. Here, we developed a somatic CRISPR/Cas9 mutagenesis s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f3e88720028d1c1acd19d4e081944a9
https://doi.org/10.1158/2159-8290.c.6549708.v1
https://doi.org/10.1158/2159-8290.c.6549708.v1
Autor:
Daniel Schramek, Geoffrey M. Wahl, Miguel Angel Pujana, Erik S. Knudsen, Agnieszka K. Witkiewicz, Michael D. Wilson, Hartland W. Jackson, Jeffrey L. Wrana, Therese Sørlie, David W. Cescon, Sean E. Egan, Gary D. Bader, Rod Bremner, Sampath K. Loganathan, Seda Barutcu, Thomas Nguyen, Jeff C. Liu, Masahiro Narimatsu, Daniel Trcka, Katelyn J. Kozma, Robin H. Oh, YiQing Lü, Andrew Elia, Sana Alvi, Ricky Tsai, Somaieh Afiuni-Zadeh, Samah El Ghamrasni, Helga Bergholtz, Ahmad Malik, Katie Teng, Roderic Espin, Liis Uuskula-Reimand, Minggao Liang, Zhibo Ma, Khalid N. Al-Zahrani, Ellen Langille
Supplementary Data from Loss of Epigenetic Regulation Disrupts Lineage Integrity, Induces Aberrant Alveogenesis, and Promotes Breast Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a0b4da81cbb00416f796f44e9fdd2b9
https://doi.org/10.1158/2159-8290.22541622.v1
https://doi.org/10.1158/2159-8290.22541622.v1
Autor:
H. Raza Ali, Zsuzsanna Varga, Savas D. Soysal, Walter P. Weber, Simone Muenst, Bernd Bodenmiller, Robert Mechera, Jana R. Fischer, Vito R T Zanotelli, Hartland W. Jackson, Holger Moch
Publikováno v:
Nature. 578:615-620
Single-cell analyses have revealed extensive heterogeneity between and within human tumours1–4, but complex single-cell phenotypes and their spatial context are not at present reflected in the histological stratification that is the foundation of m
Autor:
Zhibo Ma, Ricky Tsai, Miquel Angel Pujana, Geoffrey M. Wahl, Seda Barutcu, Sampath Kumar Loganathan, Katelyn. J. Kozma, Roderic Espín, Rod Bremner, Dan Trcka, Ellen Langille, Daniel Schramek, Ahmad Malik, Thomas Nguyen, Jeff C. Liu, Sean E. Egan, Katie Teng, Erik S. Knudsen, Gary D. Bader, Jeff Wrana, Hartland W. Jackson, Khalid N Al-Zahrani
Systematically investigating the scores of genes mutated in cancer and discerning real drivers from inconsequential bystanders is a prerequisite for Precision Medicine, but remains challenging. Here, we developed a somatic CRISPR/Cas9 mutagenesis scr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26ac8b66e265f67391d390be78544478
https://doi.org/10.1101/2021.10.22.465428
https://doi.org/10.1101/2021.10.22.465428
Autor:
Ellen Langille, Khalid N. Al-Zahrani, Zhibo Ma, Minggao Liang, Liis Uuskula-Reimand, Roderic Espin, Katie Teng, Ahmad Malik, Helga Bergholtz, Samah El Ghamrasni, Somaieh Afiuni-Zadeh, Ricky Tsai, Sana Alvi, Andrew Elia, YiQing Lü, Robin H. Oh, Katelyn J. Kozma, Daniel Trcka, Masahiro Narimatsu, Jeff C. Liu, Thomas Nguyen, Seda Barutcu, Sampath K. Loganathan, Rod Bremner, Gary D. Bader, Sean E. Egan, David W. Cescon, Therese Sørlie, Jeffrey L. Wrana, Hartland W. Jackson, Michael D. Wilson, Agnieszka K. Witkiewicz, Erik S. Knudsen, Miguel Angel Pujana, Geoffrey M. Wahl, Daniel Schramek
Publikováno v:
Cancer Discov
Systematically investigating the scores of genes mutated in cancer and discerning disease drivers from inconsequential bystanders is a prerequisite for precision medicine but remains challenging. Here, we developed a somatic CRISPR/Cas9 mutagenesis s