Discovery of Small Molecule Interleukin 17A Inhibitors with Novel Binding Mode and Stoichiometry: Optimization of DNA-Encoded Chemical Library Hits to In Vivo Active Compounds.

Autor: Ramos AL; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Goedken ER; AbbVie Bioresearch Center, Worcester, Massachusetts 01605, United States., Frank KE; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Argiriadi MA; AbbVie Bioresearch Center, Worcester, Massachusetts 01605, United States., Bazzaz S; X-Chem, Waltham, Massachusetts 02453, United States., Bian Z; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Brown JTC; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Centrella PA; X-Chem, Waltham, Massachusetts 02453, United States., Chen HJ; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Disch JS; X-Chem, Waltham, Massachusetts 02453, United States., Donner PL; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Duignan DB; AbbVie Bioresearch Center, Worcester, Massachusetts 01605, United States., Gikunju D; X-Chem, Waltham, Massachusetts 02453, United States., Greszler SN; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Guié MA; X-Chem, Waltham, Massachusetts 02453, United States., Habeshian S; X-Chem, Waltham, Massachusetts 02453, United States., Hartl HE; X-Chem, Waltham, Massachusetts 02453, United States., Hein CD; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Hutchins CW; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Jetson R; X-Chem, Waltham, Massachusetts 02453, United States., Keefe AD; X-Chem, Waltham, Massachusetts 02453, United States., Khan H; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Li HQ; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Olszewski A; X-Chem, Waltham, Massachusetts 02453, United States., Ortiz Cardona BJ; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Osuma A; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Panchal SC; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Phelan R; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Qiu W; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Shotwell JB; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Shrestha A; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Srikumaran M; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Su Z; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Sun C; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Upadhyay AK; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Wood MD; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Wu H; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Zhang R; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Zhang Y; X-Chem, Waltham, Massachusetts 02453, United States., Zhao G; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Zhu H; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Webster MP; AbbVie Incorporated, North Chicago, Illinois 60064, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Apr 25; Vol. 67 (8), pp. 6456-6494. Date of Electronic Publication: 2024 Apr 04.