Discovery of Small Molecule Interleukin 17A Inhibitors with Novel Binding Mode and Stoichiometry: Optimization of DNA-Encoded Chemical Library Hits to In Vivo Active Compounds.

Autor: Ramos AL; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Goedken ER; AbbVie Bioresearch Center, Worcester, Massachusetts 01605, United States., Frank KE; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Argiriadi MA; AbbVie Bioresearch Center, Worcester, Massachusetts 01605, United States., Bazzaz S; X-Chem, Waltham, Massachusetts 02453, United States., Bian Z; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Brown JTC; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Centrella PA; X-Chem, Waltham, Massachusetts 02453, United States., Chen HJ; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Disch JS; X-Chem, Waltham, Massachusetts 02453, United States., Donner PL; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Duignan DB; AbbVie Bioresearch Center, Worcester, Massachusetts 01605, United States., Gikunju D; X-Chem, Waltham, Massachusetts 02453, United States., Greszler SN; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Guié MA; X-Chem, Waltham, Massachusetts 02453, United States., Habeshian S; X-Chem, Waltham, Massachusetts 02453, United States., Hartl HE; X-Chem, Waltham, Massachusetts 02453, United States., Hein CD; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Hutchins CW; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Jetson R; X-Chem, Waltham, Massachusetts 02453, United States., Keefe AD; X-Chem, Waltham, Massachusetts 02453, United States., Khan H; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Li HQ; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Olszewski A; X-Chem, Waltham, Massachusetts 02453, United States., Ortiz Cardona BJ; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Osuma A; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Panchal SC; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Phelan R; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Qiu W; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Shotwell JB; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Shrestha A; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Srikumaran M; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Su Z; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Sun C; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Upadhyay AK; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Wood MD; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Wu H; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Zhang R; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Zhang Y; X-Chem, Waltham, Massachusetts 02453, United States., Zhao G; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Zhu H; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Webster MP; AbbVie Incorporated, North Chicago, Illinois 60064, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Apr 25; Vol. 67 (8), pp. 6456-6494. Date of Electronic Publication: 2024 Apr 04.

Running-in friction of hip joint replacements can be significantly reduced: The effect of surface-textured acetabular cup.

Autor: Nečas, David, Usami, Hatsuhiko, Niimi, Tatsuya, Sawae, Yoshinori, Křupka, Ivan, Hartl, Martin

Publikováno v: Friction (2223-7704); Dec2020, Vol. 8 Issue 6, p1137-1152, 16p

Trial and error.

Autor: Mason, Michael

Publikováno v: Health (Time Inc. Health). Jan/Feb94, Vol. 8 Issue 1, p76. 8p. 2 Color Photographs.

Chains Versus Independents: IV. The Fighting Independents.

Autor: Ernst, Edward G., Hartl, Emil M.

Publikováno v: Nation; 12/3/1930, Vol. 131 Issue 3413, p606-608, 3p

Lack of biodiesel fuels frustrations.

Autor: Bertola, David

Publikováno v: Business First of Buffalo. 9/7/2007, Vol. 23 Issue 51, p1-56. 2p.