Relationships and Mendelian Randomization of Gut Microbe-Derived Metabolites with Metabolic Syndrome Traits in the METSIM Cohort.

Autor: Mirzaei S; Department of Medicine, Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90055, USA.; School of Nursing, University of California, Los Angeles, CA 90095, USA., DeVon HA; School of Nursing, University of California, Los Angeles, CA 90095, USA., Cantor RM; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA., Cupido AJ; Department of Vascular Medicine, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam Cardiovascular Sciences, 1007 AZ Amsterdam, The Netherlands., Pan C; Department of Medicine, Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90055, USA., Ha SM; Department of Integrative Biology and Physiology, University of California, Los Angeles, CA 90095, USA., Fernandes Silva L; Department of Medicine, Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90055, USA.; Department of Clinical Medicine, Internal Medicine, University of Eastern Finland, 70210 Kuopio, Finland., Hilser JR; Department of Population & Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA 90032, USA.; Department of Biochemistry & Molecular Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA., Hartiala J; Department of Population & Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA 90032, USA., Allayee H; Department of Population & Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA 90032, USA.; Department of Biochemistry & Molecular Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA., Rey FE; Department of Bacteriology, University of Wisconsin-Madison, Madison, WI 53706, USA., Laakso M; Department of Clinical Medicine, Internal Medicine, University of Eastern Finland, 70210 Kuopio, Finland., Lusis AJ; Department of Medicine, Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90055, USA.; Department of Human Genetics and Microbiology, Immunology & Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.

Publikováno v: Metabolites [Metabolites] 2024 Mar 20; Vol. 14 (3). Date of Electronic Publication: 2024 Mar 20.

Towards automated detection of psychosocial risk factors with text mining.

Autor: Uronen, L, Moen, H, Teperi, S, Martimo, K-P, Hartiala, J, Salanterä, S

Publikováno v: Occupational Medicine; Apr2020, Vol. 70 Issue 3, p203-206, 4p, 2 Charts

Association of Chromosome 9p21 With Subsequent Coronary Heart Disease Events

Autor: Patel, RS, Schmidt, AF, Tragante, V, McCubrey, RO, Holmes, MV, Howe, LJ, Direk, K, Åkerblom, A, Leander, K, Virani, SS, Kaminski, KA, Muehlschlegel, JD, Dubé, M-P, Allayee, H, Almgren, P, Alver, M, Baranova, EV, Behlouli, H, Boeckx, B, Braund, PS, Breitling, LP, Delgado, G, Duarte, NE, Dufresne, L, Eriksson, N, Foco, L, Gijsberts, CM, Gong, Y, Hartiala, J, Heydarpour, M, Hubacek, JA, Kleber, M, Kofink, D, Kuukasjärvi, P, Lee, V-V, Leiherer, A, Lenzini, PA, Levin, D, Lyytikäinen, L-P, Martinelli, N, Mons, U, Nelson, CP, Nikus, K, Pilbrow, AP, Ploski, R, Sun, YV, Tanck, MWT, Tang, WHW, Trompet, S, Van Der Laan, SW, Van Setten, J, Vilmundarson, RO, Anselmi, C, Vlachopoulou, E, Boerwinkle, E, Briguori, C, Carlquist, JF, Carruthers, KF, Casu, G, Deanfield, J, Deloukas, P, Dudbridge, F, Fitzpatrick, N, Gigante, B, James, S, Lokki, M-L, Lotufo, PA, Marziliano, N, Mordi, IR, Muhlestein, JB, Newton-Cheh, C, Pitha, J, Saely, CH, Samman-Tahhan, A, Sandesara, PB, Teren, A, Timmis, A, Van De Werf, F, Wauters, E, Wilde, AAM, Ford, I, Stott, DJ, Algra, A, Andreassi, MG, Ardissino, D, Arsenault, BJ, Ballantyne, CM, Bergmeijer, TO, Bezzina, CR, Body, SC, Bogaty, P, De Borst, GJ, Brenner, H, Burkhardt, R, Carpeggiani, C, Condorelli, G, Cooper-Dehoff, RM, Cresci, S, De Faire, U, Doughty, RN, Drexel, H, Engert, JC, Fox, KAA, Girelli, D, Hagström, E, Hazen, SL, Held, C, Hemingway, H, Hoefer, IE, Hovingh, GK, Johnson, JA, De Jong, PA, Jukema, JW, Kaczor, MP, Kähönen, M, Kettner, J, Kiliszek, M, Klungel, OH, Lagerqvist, B, Lambrechts, D, Laurikka, JO, Lehtimäki, T, Lindholm, D, Mahmoodi, BK, Der Zee, AH, McPherson, R, Melander, O, Metspalu, A, Pepinski, W, Olivieri, O, Opolski, G, Palmer, CN, Pasterkamp, G, Pepine, CJ, Pereira, AC, Pilote, L, Quyyumi, AA, Richards, AM, Sanak, M, Scholz, M, Siegbahn, A, Sinisalo, J, Smith, JG, Spertus, JA, Stewart, AFR, Szczeklik, W, Szpakowicz, A, Berg, JM, Thanassoulis, G, Thiery, J, Van Der Graaf, Y, Visseren, FLJ, Waltenberger, J, Van Der Harst, P, Tardif, J-C, Sattar, N, Lang, CC, Paré, G, Brophy, JM, Anderson, JL, März, W, Wallentin, L, Cameron, VA, Horne, BD, Samani, NJ, Hingorani, AD, Asselbergs, FW

Genetic variation at chromosome 9p21 is a recognized risk factor for coronary heart disease (CHD). However, its effect on disease progression and subsequent events is unclear, raising questions about its value for stratification of residual risk.A va

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::86d67053a6d54128f7e80f8f66460c21
http://hdl.handle.net/11562/1028981

Comparative Genome-Wide Association Studies in Mice and Humans for Trimethylamine N -Oxide, a Proatherogenic Metabolite of Choline and l -Carnitine

Autor: Hartiala, J., Bennett, B.J., Tang, W.H.W., Wang, Z., Stewart, A.F.R., Roberts, R., McPherson, R., CARDIoGRAM Consortium (Döring, A., Illig, T., Klopp, N., Meisinger, C., Meitinger, T., Peters, A., Wichmann, H.-E.), Lusis, A., Hazen, S.L., Allayee, H.

Publikováno v: Arterioscler. Thromb. Vasc. Biol. 34, 1307-1313 (2014)

Objective— Elevated levels of plasma trimethylamine N -oxide (TMAO), the product of gut microbiome and hepatic-mediated metabolism of dietary choline and l -carnitine, have recently been identified as a novel risk factor for the development of athe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::411b4bea7e68356adb7e9109f66f3f50
https://doi.org/10.1161/atvbaha.114.303252

Allergic sensitization is associated with rhinovirus-, but not other virus-, induced wheezing in children.

Autor: Jartti, T., Kuusipalo, H., Vuorinen, T., Söderlund-Venermo, M., Allander, T., Waris, M., Hartiala, J., Ruuskanen, O.

Publikováno v: Pediatric Allergy & Immunology; Nov2010, Vol. 21 Issue 7, p1008-1014, 7p, 1 Chart, 1 Graph