Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Hartford W. Manning"'
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Cyclopentannulation by an Iterative Process of Sequential Claisen Rearrangement and Enyne Radical Closure: Routes to Triquinane and Propellane Systems and Use in the Synthesis of (±)-Ceratopicanol
Autor: Steven R. Magnuson, Derrick L. J. Clive, Darrin L. Mayhew, and Hartford W. Manning
Publikováno v: The Journal of Organic Chemistry. 61:2095-2108
Cycloalkenyl acetylenes 4, which are easily prepared from allylic alcohols by Claisen rearrangement and homologation (1 → 4), generally undergo radical cyclization (4 → 6) on treatment with stannyl radicals. The products (6) can themselves be con
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2827d629684af901a71c99310b4ecc33
https://doi.org/10.1021/jo951930h
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2
Open-chain nitrogen compounds. Part XII. Methanolysis of 3-alkyl-3,4-dihydro-1,2,3-benzotriazin-4-ols: evidence for ring-chain tautomerism with the cytotoxic monoalkyltriazenes
Autor: Hartford W. Manning, Ronald J. LaFrance, Keith Vaughan
Publikováno v: Canadian Journal of Chemistry. 65:292-297
A series of 4-hydroxy-3,4-dihydro-1,2,3-benzotriazines ("triazinols"), potential pro-drugs for the cytotoxic monoalkyltriazenes, have been investigated for anti-tumor activity and have been found to have marginal activity against the TLX5 tumor. The
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c9c2a0565206c5c148e73bf116904089
https://doi.org/10.1139/v87-048
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4
Open chain nitrogen compounds. Part XIII. 1-Aryl-3-arylthiomethyl-3-methyltriazenes and 3-(arylazo)-1,3-thiazolidines
Autor: Hartford W. Manning, Marcus P. Merrin, Keith Vaughan, Donald L. Hooper
Publikováno v: Canadian Journal of Chemistry. 66:2487-2491
Reaction of 3-acetoxymethyl-1-aryl-3-methyltriazenes with sodium thiophenolate or thiocresolate in anhydrous dimethylformamide affords a new series of 3-arylthiomethyltriazenes (2), Ar-S-CH2-NMe-N=N-Ar′. These triazenes are remarkably labile in aqu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f659defd826c0ac7fc081023ed0fa3ac
https://doi.org/10.1139/v88-391
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5
Open-chain nitrogen compounds. Part VI. The formation of bis(1-aryl-3- methyltriazen-3-ylmethyl) methylamines in the reaction of diazonium ions with mixtures of formaldehyde and methylamine
Autor: Hartford W. Manning, Ronald J. LaFrance, Chantal M. Hemens, Keith Vaughan, York Tang
Publikováno v: Canadian Journal of Chemistry. 62:749-754
The synthesis of a series of N,N-bis(1-aryl-3-methyltriazen-3-ylmethyl) methylamines from coupling diazonium salts with mixtures of methylamine and formaldehyde is described. These novel bis-triazenes, or heptazanonadienes, have significant anti-tumo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7b1ad814e3773a8450e1d4cbd6cfd125
https://doi.org/10.1139/v84-126
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6
Open-chain nitrogen compounds. Part V. Hydroxymethyltriazenes: synthesis of some new alkyl homologues of the anti-tumour 3-methyl-3-hydroxymethyltriazenes and preparation of the derived acetoxymethyl-, benzoyloxymethyl-, and methoxymethyltriazenes
Autor: Keith Vaughan, Chantal M. Hemens, Hartford W. Manning, York Tang, Ronald J. LaFrance
Publikováno v: Canadian Journal of Chemistry. 62:741-748
The synthesis of some new 1-aryl-3-alkyl-3-hydroxymethyltriazenes is described. The method of coupling a diazonium salt with an alkylamine/formaldehyde mixture has been extended to (a) some diazonium ions with para substituents other than—M groups,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9d1f54b4c4cba882d6d982298c380a57
https://doi.org/10.1139/v84-125
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7
Open-chain nitrogen compounds. Part IX. 1,2,3-Triazolo[1,5-a]quinazoline and its 5-alkyl and 5-aryl derivatives from alumina-catalysed cyclization of 1-(2′-acylphenyl)-3-cyanomethyltriazene
Autor: Ronald J. LaFrance, Keith Vaughan, Donald L. Hooper, Hartford W. Manning
Publikováno v: Canadian Journal of Chemistry. 64:250-254
Alumina-catalysed cyclization of a series of 1-(2′-acylphenyl)-3-cyanomethyltriazenes (5) affords good yields of the previously unreported 5-alkyl- and 5-aryl-1,2,3-triazolo[1,5-a]quinazolines (8). The parent heterocycle, 1,2,3-triazolo[1,5-a]quina
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f120c44f2671fa5de01abbaf4b05ee4b
https://doi.org/10.1139/v86-043
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8
ChemInform Abstract: OPEN-CHAIN NITROGEN COMPOUNDS. 7. SYNTHESIS AND HIGH-RESOLUTION NUCLEAR MAGNETIC REASONANCE SPECTROSCOPY OF 3-(ARYLAZO)-1,3-OXAZOLIDINES AND 3-(ARYLAZO)TETRAHYDRO-1,3-OXAZINES
Autor: Keith Vaughan, Ronald J. LaFrance, Hartford W. Manning
Publikováno v: Chemischer Informationsdienst. 16
Durch Reaktion der Diazoniumsalze (I) mit Gemischen der Aldehyde (III) und der Ethanolamine (II) werden die Triazene (IV) erhalten, deren Konstitution durch 1H- und 13C-NMR-spektroskopische Untersuchungen gesichert wird.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8b3b6d2677feb6b5e4b309609e770cf9
https://doi.org/10.1002/chin.198543250
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