Akt and mTOR signalling in WHO grade II and III meningiomas

Autor: Baumgarten, P, Bernatz, S, Senft, C, Seifert, V, Wagner, M, Steinbach, J, Harter, PN, Ronellenfitsch, M

Publikováno v: 70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie; 20190512-20190515; Würzburg; DOCP087 /20190508/

Objective: Surgical resection and radiotherapy are still the main pillars of meningioma treatment. WHO Grade I meningiomas are benign and complete resection can be curative. Complete resection for atypical (WHO°II) and malignant (WHO °III) meningio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c742566e4f459f4b86827abda3fb174

Ki67 proliferation rate, macroscopic brain invasion and Simpson Score are predictors for tumor recurrence in WHO grade II meningiomas

Autor: Baumgarten, P, Bernatz, S, Senft, C, Seifert, V, Mittelbronn, M, Harter, PN

Publikováno v: 67. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 1. Joint Meeting mit der Koreanischen Gesellschaft für Neurochirurgie (KNS); 20160612-20160615; Frankfurt am Main; DOCMO.11.05 /20160608/

Objective: According to the current WHO classification, meningiomas are classified as grade II if they display (I) signs of atypia, (II) chordoid or clear cell differentiation, (III) increased mitotic activity or (IV) histopathological brain invasion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cff5570e7d936e4f91c73344d1196c2

VEGF-receptor 3 as promising therapeutic target in malignant gliomas

Autor: Gieser, E, Albrecht, V, Harter, PN, Tonn, JC, Schichor, C, Glass, R

Publikováno v: 64. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC); 20130526-20130529; Düsseldorf; DOCMO.05.06 /20130521/

Objective: VEGF-R3 plays an important role in developmental and lymphatic angiogenesis and is expressed in high-grade gliomas, but not in the normal brain. Herein, we investigated the role of VEGF-R3 as a potential specific and direct marker for tumo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca145e389e38f3f951a792bfd740eec1

Taxane treatment reduces peripheral tumor growth but is associated with increased CNS metastases in a murine model of HER2-positive breast cancer

Autor: Harter, PN, Mischo, A, Müller, K, Kleber, S, Zachskorn, C, Renner, C, Steeg, PS, Pestalozzi, B, Mittelbronn, M

Publikováno v: 57th Annual Meeting of the German Society for Neuropathology and Neuroanatomy (DGNN); 20120912-20120915; Erlangen; DOC12dgnnPP5.8 /20120911/

Breast cancer is the most frequent neoplasm in females and frequently associated with CNS-metastases. While the overall incidence of CNS-metastases reaches approximately 15%, much higher rates are observed in patients with HER2-positive breast cancer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de0d7f7190b92cb846ac4ed2c6fb0a96

Far Upstream Element [FUSE] Binding Protein 1 (FUBP1) expression is associated with increased proliferative activity, p53 accumulation and the presence of mutations in human gliomas

Autor: Baumgarten, P, Harter, PN, Tönjes, M, Capper, D, Blank, AE, Schwamb, B, Rabenhorst, U, Kögel, D, Rieker, RJ, Plate, KH, Ohgaki, H, Radlwimmer, B, Zörnig, M, Mittelbronn, M

Publikováno v: 57th Annual Meeting of the German Society for Neuropathology and Neuroanatomy (DGNN); 20120912-20120915; Erlangen; DOC12dgnnPP3.14 /20120911/

The Far Upstream Element [FUSE] Binding Protein 1 (FUBP1) regulates target genes, such as the cell cycle regulators MYC and p21. FUBP1 is upregulated in many solid tumors and functions as an oncoprotein by stimulating proliferation and inhibiting apo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c05cb4fa20a369fc4696fad66f6e6523