Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

Autor: Aragones J, Schneider M, Van Geyte K, Fraisl P, Dresselaers T, Mazzone M, Dirkx R, Zacchigna S, Lemieux H, Jeoung NH, Lambrechts D, Bishop T, Lafuste P, Diez-Juan A, Harten SK, Van Noten P, De Bock K, Willam C, Tjwa M, Grosfeld A, Navet R, Moons L, Vandendriessche T, Deroose C, Wijeyekoon B, Nuyts J, Jordan B, Silasi-Mansat R, Lupu F, Dewerchin M, Pugh C, Salmon P, Mortelmans L, Gallez B, Gorus F, Buyse J, Sluse F, Harris RA, Gnaiger E, Hespel P, Van Hecke P, Schuit F, Van Veldhoven P, Ratcliffe P, Baes

Publikováno v: Nature Genetics.

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Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation.

Autor: Del Monte-Nieto G; Developmental and Stem Cell Biology Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia. g.delmonte@victorchang.edu.au.; St Vincent's Clinical School, University of New South Wales, Kensington, New South Wales, Australia. g.delmonte@victorchang.edu.au., Ramialison M; Australian Regenerative Medicine Institute, Monash University, Clayton, Victoria, Australia., Adam AAS; Developmental and Stem Cell Biology Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia., Wu B; Departments of Genetics, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York, NY, USA., Aharonov A; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., D'Uva G; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Bourke LM; Epigenetics Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.; School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia., Pitulescu ME; Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, Münster, Germany.; Faculty of Medicine, University of Münster, Münster, Germany., Chen H; Departments of Pediatrics and Medical and Molecular Genetics, Riley Heart Research Center, Wells Center for Pediatric Research, Indiana University, Indianapolis, IN, USA., de la Pompa JL; Intercellular Signalling in Cardiovascular Development and Disease Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.; Ciber cardiovascular, ISCIII, Madrid, Spain., Shou W; Departments of Pediatrics and Medical and Molecular Genetics, Riley Heart Research Center, Wells Center for Pediatric Research, Indiana University, Indianapolis, IN, USA., Adams RH; Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, Münster, Germany.; Faculty of Medicine, University of Münster, Münster, Germany., Harten SK; Epigenetics Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.; School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia., Tzahor E; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Zhou B; Departments of Genetics, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York, NY, USA., Harvey RP; Developmental and Stem Cell Biology Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia. r.harvey@victorchang.edu.au.; St Vincent's Clinical School, University of New South Wales, Kensington, New South Wales, Australia. r.harvey@victorchang.edu.au.; School of Biotechnology and Biomolecular Science, University of New South Wales, Kensington, New South Wales, Australia. r.harvey@victorchang.edu.au.

Publikováno v: Nature [Nature] 2018 May; Vol. 557 (7705), pp. 439-445. Date of Electronic Publication: 2018 May 09.

Loss of Rearranged L-Myc Fusion (RLF) results in defects in heart development in the mouse.

Autor: Bourke LM; Epigenetics Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland 4006, Australia; School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland 4006, Australia., Del Monte-Nieto G; The Victor Chang Cardiac Research Institute, Sydney, NSW 200, Australia; St. Vincent's Clinical School, University of New South Wales, Kensington 2052, Australia., Outhwaite JE; School of Biomedical Sciences, Faculty of Medicine and Biomedical Sciences, The University of Queensland, St. Lucia, Queensland 4072, Australia., Bharti V; Epigenetics Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland 4006, Australia., Pollock PM; School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland 4006, Australia., Simmons DG; School of Biomedical Sciences, Faculty of Medicine and Biomedical Sciences, The University of Queensland, St. Lucia, Queensland 4072, Australia., Adam A; The Victor Chang Cardiac Research Institute, Sydney, NSW 200, Australia., Hur SS; The Victor Chang Cardiac Research Institute, Sydney, NSW 200, Australia., Maghzal GJ; The Victor Chang Cardiac Research Institute, Sydney, NSW 200, Australia., Whitelaw E; Department of Genetics, La Trobe Institute for Molecular Science, Department of Genetics, La Trobe University, Bundoora, Victoria 3086, Australia., Stocker R; The Victor Chang Cardiac Research Institute, Sydney, NSW 200, Australia; School of Medical Sciences, University of New South Wales, Kensington 2052, Australia., Suter CM; The Victor Chang Cardiac Research Institute, Sydney, NSW 200, Australia; St. Vincent's Clinical School, University of New South Wales, Kensington 2052, Australia., Harvey RP; The Victor Chang Cardiac Research Institute, Sydney, NSW 200, Australia; St. Vincent's Clinical School, University of New South Wales, Kensington 2052, Australia; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Kensington 2052, Australia. Electronic address: r.harvey@victorchang.edu.au., Harten SK; Epigenetics Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland 4006, Australia. Electronic address: sarah.harten@qimrberghofer.edu.au.

Publikováno v: Differentiation; research in biological diversity [Differentiation] 2017 Mar - Apr; Vol. 94, pp. 8-20. Date of Electronic Publication: 2016 Dec 05.

Identification of novel hypomorphic and null mutations in Klf1 derived from a genetic screen for modifiers of α-globin transgene variegation.

Autor: Sorolla A; Epigenetics Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia., Tallack MR; Mater-UQ Research Institute, The University of Queensland, Translational Research Institute, Woolloongabba, QLD 4102, Australia; School of Medicine, The University of Queensland, St Lucia, QLD 4072, Australia., Oey H; La Trobe Institute for Molecular Science, Department of Genetics, La Trobe University, Bundoora, VIC 3086, Australia., Harten SK; Epigenetics Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia., Daxinger LC; Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands., Magor GW; Mater-UQ Research Institute, The University of Queensland, Translational Research Institute, Woolloongabba, QLD 4102, Australia., Combes AN; Epigenetics Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia., Ilsley M; Mater-UQ Research Institute, The University of Queensland, Translational Research Institute, Woolloongabba, QLD 4102, Australia., Whitelaw E; Epigenetics Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia; La Trobe Institute for Molecular Science, Department of Genetics, La Trobe University, Bundoora, VIC 3086, Australia. Electronic address: E.Whitelaw@latrobe.edu.au., Perkins AC; Mater-UQ Research Institute, The University of Queensland, Translational Research Institute, Woolloongabba, QLD 4102, Australia; School of Medicine, The University of Queensland, St Lucia, QLD 4072, Australia; Department of Cancer Services, Princess Alexandra Hospital, Woolloongabba, QLD 4102, Australia. Electronic address: andrew.perkins@mater.uq.edu.au.

Publikováno v: Genomics [Genomics] 2015 Feb; Vol. 105 (2), pp. 116-22. Date of Electronic Publication: 2014 Oct 31.