Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Hart S Dengler"'
Autor:
Jane R. Kenny, Mathew Williams, Richard Beasley, A. Mcgregor, Maria E. Wilson, Avi Eliahu, Irene Braithwaite, Matthew R. Durk, Jennifer Tom, Fang Cai, Ryan Owen, Joshua Galanter, Hart S. Dengler, Rui Zhu, Mark Zak, Hubert Chen
Publikováno v:
Journal of Allergy and Clinical Immunology. 148:783-789
Background The Janus kinase (JAK) pathway mediates the activity of many asthma-relevant cytokines, including IL-4 and IL-13. GDC-0214 is a potent, inhaled, small-molecule JAK inhibitor being developed for the treatment of asthma. Objective We sought
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5929ba8f48ae2f44a826e35cc263796
https://doi.org/10.1016/j.jaci.2021.02.042
https://doi.org/10.1016/j.jaci.2021.02.042
Autor:
Sarah E. Headland, Hart S. Dengler, Daqi Xu, Grace Teng, Christine Everett, Rojo A. Ratsimandresy, Donghong Yan, Jing Kang, Kirthana Ganeshan, Evgeniya V. Nazarova, Sarah Gierke, Christopher J. Wedeles, Riccardo Guidi, Daryle J. DePianto, Katrina B. Morshead, Alison Huynh, Jessica Mills, Sean Flanagan, Shannon Hambro, Victor Nunez, Joanna E. Klementowicz, Yongchang Shi, Jianyong Wang, Jack Bevers, Vladimir Ramirez-Carrozzi, Rajita Pappu, Alex Abbas, Jason Vander Heiden, David F. Choy, Rajbharan Yadav, Zora Modrusan, Reynold A. Panettieri, Cynthia Koziol-White, William F. Jester, Brendan J. Jenkins, Yi Cao, Christine Clarke, Cary Austin, Daniel Lafkas, Min Xu, Paul J. Wolters, Joseph R. Arron, Nathaniel R. West, Mark S. Wilson
Publikováno v:
Science translational medicine. 14(627)
Exacerbations of symptoms represent an unmet need for people with asthma. Bacterial dysbiosis and opportunistic bacterial infections have been observed in, and may contribute to, more severe asthma. However, the molecular mechanisms driving these exa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46323ac4e1c7c49de3c9a3a4fd365072
https://pubmed.ncbi.nlm.nih.gov/35110748
https://pubmed.ncbi.nlm.nih.gov/35110748
Autor:
Jonathan M. Maher, Rui Zhang, Gopinath Palanisamy, Kimberly Perkins, Lynda Liu, Patrick Brassil, Alexander McNamara, Arthur Lo, Adam D. Hughes, Jitendra Kanodia, Svitlana Kulyk, Kristen J. Nikula, Hart S. Dengler, Amy Scandurra, Ingrid Lua, Eric Harstad
Publikováno v:
Toxicology and Applied Pharmacology. 438:115905
Systemic therapies targeting transforming growth factor beta (TGFβ) or TGFβR1 kinase (ALK5) have been plagued by toxicities including cardiac valvulopathy and bone physeal dysplasia in animals, posing a significant challenge for clinical developmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4606385857511b66512fdf43a79a65bf
https://doi.org/10.1016/j.taap.2022.115905
https://doi.org/10.1016/j.taap.2022.115905
Autor:
John Liu, Stephanie Addo, Gauri Deshmukh, Wyne P. Lee, Mark Zak, Ivan Peng, Hart S. Dengler, Julia Lloyd, Simon Charles Goodacre, Nicholas Charles Ray, Eric Suto, Pawan Bir Kohli, Savita Ubhayakar, Cristine M. Quiason-Huynh, Xiumin Wu, Cornelia H. Rinderknecht, Sheerin K. Shahidi-Latham, Youngsu Kwon, Marya Liimatta, Janet Jackman, Gary Cain, Jane R. Kenny, Gary Salmon, Brent S. McKenzie, Mike Briggs, Adam R. Johnson, Kathy Barrett, Nico Ghilardi
Publikováno v:
Science translational medicine. 10(468)
Preclinical and clinical evidence indicates that a subset of asthma is driven by type 2 cytokines such as interleukin-4 (IL-4), IL-5, IL-9, and IL-13. Additional evidence predicts pathogenic roles for IL-6 and type I and type II interferons. Because
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e75f088b1fe1e780a2e75c42e77ea103
https://pubmed.ncbi.nlm.nih.gov/30463918
https://pubmed.ncbi.nlm.nih.gov/30463918
Autor:
Wenjun Ouyang, Mike Reichelt, Lauri Diehl, Jay K. Kolls, Noelyn M. Kljavin, Nico Ghilardi, Hart S. Dengler, Pawan Kumar, Linda Rangell, Vincent Feng-Sheng Shih, Jennifer H. Cox
Publikováno v:
Proceedings of the National Academy of Sciences. 111:13942-13947
Mammalian hosts are colonized with commensal microbes in various mucosal and epithelial tissues, including the intestinal tract. In mice, the presence of segmented filamentous bacteria (SFB) promotes Th17 differentiation and the development of autoim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f90d5b262ddb659ed072e26ec6bc045f
https://doi.org/10.1073/pnas.1323852111
https://doi.org/10.1073/pnas.1323852111
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:126658
Multiple asthma-relevant cytokines including IL-4, IL-5, IL-13, and TSLP depend upon JAKs for signaling. JAK inhibition may, therefore, offer a novel intervention strategy for patients with disease refractory to current standards of care. Multiple sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a27ba1cb830fa340525357ef60d0fded
https://doi.org/10.1016/j.bmcl.2019.126658
https://doi.org/10.1016/j.bmcl.2019.126658
Autor:
David A. Fulcher, Cecile King, Jennifer H. Cox, Cindy S. Ma, Noelyn M. Kljavin, Nico Ghilardi, Frederic J. de Sauvage, Melanie Wong, Nandhini Ramamoorthi, Dimitry M. Danilenko, Marcel Batten, Matthew C. Cook, Stuart G. Tangye, Hart S. Dengler, Patrick Caplazi
Publikováno v:
The Journal of Experimental Medicine
IL-27 signaling directly into T cells is needed for follicular T helper cell survival, germinal center formation, and the production of T cell–dependent high-affinity antibodies in mice.
Maturation and selection of high-affinity B cell clones
Maturation and selection of high-affinity B cell clones
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::999d4691d389bf302a9eeb255005f202
http://europepmc.org/articles/PMC3005229
http://europepmc.org/articles/PMC3005229
Autor:
Matthew H. Cato, Hart S. Dengler, Christopher J. Del Nagro, Cecille D. Browne, Robert C. Rickert
Publikováno v:
Immunity. 31(5):749-760
SummaryAnergy is a critical physiologic mechanism to censor self-reactive B cells. However, a biochemical understanding of how anergy is achieved and maintained is lacking. Herein, we investigated the role of the phosphoinositide 3-kinase (PI3K) lipi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13f73c371f7c00d4a8878086e2f5a447
Autor:
Sidne A. Omori, Diego H. Castrillon, Robert C. Rickert, G. V. Baracho, Shane Bruckner, Ronald A. DePinho, Karen C. Arden, Hart S Dengler
Publikováno v:
Nature Immunology. 9:1388-1398
The transcription factors Foxo1, Foxo3 and Foxo4 modulate cell fate 'decisions' in diverse systems. Here we show that Foxo1-dependent gene expression was critical at many stages of B cell differentiation. Early deletion of Foxo1 caused a substantial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4bc343d0c77031c7ee37dddd37801cf
https://doi.org/10.1038/ni.1667
https://doi.org/10.1038/ni.1667
Autor:
Hidenobu Kanda, Adam R. Johnson, Christopher A. Hurley, Mark Zak, Yingjie Lai, Kathy Barrett, Janusz J. Kulagowski, Wade S. Blair, Jan Smith, Christine Chang, Wenqian Yang, Sue J. Sohn, Hart S. Dengler, Nicholas Lewin-Koh, Lawren C. Wu, Birong Zhang, Aihe Zhou, Karen Williams, Nico Ghilardi, Jun Liang, Pawan Bir Kohli, Calum Macleod, Steven Magnuson, Anne van Abbema
TYK2 is a JAK family protein tyrosine kinase activated in response to multiple cytokines, including type I IFNs, IL-6, IL-10, IL-12, and IL-23. Extensive studies of mice that lack TYK2 expression indicate that the IFN-α, IL-12, and IL-23 pathways, b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e004314f8e104cfae5a1bf2ac2f051b6
https://europepmc.org/articles/PMC3748334/
https://europepmc.org/articles/PMC3748334/
