Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Hart Amy C"'
Publikováno v:
Burger's Medicinal Chemistry and Drug Discovery. :1-86
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::346314e8fd3ddb9cb747245e50d6ae4f
https://doi.org/10.1002/0471266949.bmc279
https://doi.org/10.1002/0471266949.bmc279
Autor:
Charu Chaudhry, Ping Zhang, Kyoung S. Kim, William J. Pitts, Cornelius Lyndon A M, Lynn M. Abell, Hart Amy C, Kevin O’Malley, Junqing Guo, Brian Carpenter, Hao Lu, Ramesh Padmanabha, Patrick J. Shaw, Mertzman Michael E, Kevin Kish, Andrew E Douglas, Matthew Pokross, John E. Macor, Deepa Calambur, Carolyn A. Weigelt
Publikováno v:
ACS Med Chem Lett
[Image: see text] Necroptosis has been implicated in a variety of disease states, and RIPK3 is one of the kinases identified to play a critical role in this signaling pathway. In an effort to identify RIPK3 kinase inhibitors with a novel profile, mec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e2ff1dc1b611e09babd108893b9d371
https://doi.org/10.1021/acsmedchemlett.9b00065
https://doi.org/10.1021/acsmedchemlett.9b00065
Autor:
M. Jure-Kunkel, Jay A. Markwalder, Weifang Shan, Bin Chen, Steven P. Seitz, Andrew Nation, John T. Hunt, Lauren Haque, Gregory D. Vite, Jennifer Donnell, David K. Williams, Kelly L. Covello, Aaron Balog, Hart Amy C, Sunil Kumar Mandal, Libing Chen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:732-736
A novel series of o-phenylenediamine-based inhibitors of indoleamine 2,3-dioxygenase (IDO) has been identified. IDO is a heme-containing enzyme, overexpressed in the tumor microenvironment of many cancers, which can contribute to the suppression of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bfe04a99487884193ada10912d2f182
https://doi.org/10.1016/j.bmcl.2018.01.010
https://doi.org/10.1016/j.bmcl.2018.01.010
Akademický článek
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Autor:
Williams, David K., Markwalder, Jay A., Balog, Aaron J., Chen, Bin, Chen, Libing, Donnell, Jennifer, Haque, Lauren, Hart, Amy C., Mandal, Sunil K., Nation, Andrew, Shan, Weifang, Vite, Gregory D., Covello, Kelly, Hunt, John T., Jure-Kunkel, Maria N., Seitz, Steven P.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 15 February 2018 28(4):732-736
Publikováno v:
In Tetrahedron 2002 58(10):2011-2026
Autor:
Hart Amy C, Javed Khan, Grebinski James W, James Kempson, Jonathan Lippy, Gretchen M. Schroeder, Theresa M. McDevitt, Ashok V. Purandare, Ragini Vuppugalla, John S. Tokarski, George L. Trainor, Junqing Guo, Jennifer Inghrim, Matthew V. Lorenzi, Dan You, Honghe Wan, John S. Sack, William J. Pitts, Yueping Zhang, Louis J. Lombardo
Publikováno v:
ACS Medicinal Chemistry Letters. 6:845-849
Early hit to lead work on a pyrrolopyridine chemotype provided access to compounds with biochemical and cellular potency against Janus kinase 2 (JAK2). Structure-based drug design along the extended hinge region of JAK2 led to the identification of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::012e89c2b8ac320dc2991a1451732264
https://doi.org/10.1021/acsmedchemlett.5b00225
https://doi.org/10.1021/acsmedchemlett.5b00225
Autor:
Patrick J. Shaw, Hart Amy C
Publikováno v:
Medicinal Chemistry Reviews ISBN: 9780996293235
Medicinal Chemistry Reviews
Medicinal Chemistry Reviews
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e9fe993299a38325e536e33bee67ac6
https://doi.org/10.29200/acsmedchemrev-v51.ch7
https://doi.org/10.29200/acsmedchemrev-v51.ch7
Autor:
Ayalew Tefferi, Theresa M. McDevitt, Ashok V. Purandare, Stuart Emanuel, Becky Penhallow, Grebinski James W, George L. Trainor, Marco M. Gottardis, Francis Y. Lee, Jennifer Hosbach, Honghe Wan, Animesh Pardanani, Terra L. Lasho, Stefan Ruepp, Dan You, John S. Tokarski, Gretchen M. Schroeder, Jennifer Inghrim, Hart Amy C, Louis J. Lombardo, Yueping Zhang, Matthew V. Lorenzi, Ragini Vuppugalla, Xia Han, Elizabeth Fitzpatrick
Publikováno v:
Cancer Research. 71:DDT01-03
Myeloproliferative diseases (MPDs) are a subset of myeloid malignancies that are characterized by the expansion of a multipotent hematopoietic stem cell. Chronic MPDs can be classified into two categories, those harboring the BCR-ABL oncogene and tho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c627273340d9262ad04f607368721c3c
https://doi.org/10.1158/1538-7445.am2011-ddt01-03
https://doi.org/10.1158/1538-7445.am2011-ddt01-03
Publikováno v:
e-EROS Encyclopedia of Reagents for Organic Synthesis
[538-75-0] C13H22N2 (MW 206.33) InChI = 1/C13H22N2/c1-3-7-12(8-4-1)14-11-15-13-9-5-2-6-10-13/h12-13H,1-10H2 InChIKey = QOSSAOTZNIDXMA-UHFFFAOYAO (powerful dehydrating agent commonly used for the preparation of amides,2 esters,3 and anhydrides;4 used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c199c98bf3e6b661438865102445e50e
https://doi.org/10.1002/047084289x.rd146.pub2
https://doi.org/10.1002/047084289x.rd146.pub2