Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Harsimran D. Singh"'
Autor:
Harsimran D. Singh, Itziar Otano, Krista Rombouts, Kasha P. Singh, Dimitra Peppa, Upkar S. Gill, Katrin Böttcher, Patrick T. F. Kennedy, Jude Oben, Massimo Pinzani, Henning Walczak, Giuseppe Fusai, William M. C. Rosenberg, Mala K. Maini
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract The TRAIL pathway can mediate apoptosis of hepatic stellate cells to promote the resolution of liver fibrosis. However, TRAIL has the capacity to bind to regulatory receptors in addition to death-inducing receptors; their differential roles
Externí odkaz:
https://doaj.org/article/0c84e0f5a1504bfe85b9a7ea0c3a5f5a
Autor:
Florent Ginhoux, David Tai, Joe Yeong, Evan W. Newell, Jerry Kok Yen Chan, Chiew Yee Loh, Xiaomeng Zhang, Hong Kai Lee, Seng Gee Lim, Weiwei Zhai, Yang Cheng, Su Pin Choo, Etienne Becht, Chung Yip Chan, Wan Jun Lim, Brian K. P. Goh, Alexander Y. F. Chung, Jinmiao Chen, Bernett Lee, Jeremy Chase Crawford, Harsimran D. Singh, Jia Qi Lim, Bavani Gunasegaran, Pierce K. H. Chow, Charles-Antoine Dutertre
Publikováno v:
SSRN Electronic Journal.
In the context of hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC), despite a range of possibilities, the antigen specificities of tumor-infiltrating T cells and their relevance to control of is largely unknown. Using highly multiple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88f09db7d97d448e2c7eb4d227c28d2e
https://doi.org/10.2139/ssrn.3760654
https://doi.org/10.2139/ssrn.3760654
Autor:
Upkar S Gill, Dimitra Peppa, Lorenzo Micco, Harsimran D Singh, Ivana Carey, Graham R Foster, Mala K Maini, Patrick T F Kennedy
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 12, Iss 8, p e1005788 (2016)
PLoS Pathogens, Vol 12, Iss 8, p e1005788 (2016)
NK cells are important antiviral effectors, highly enriched in the liver, with the potential to regulate immunopathogenesis in persistent viral infections. Here we examined whether changes in the NK pool are induced when patients with eAg-positive CH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::fadb7ef332106e827b075cc13b239e80
https://doi.org/10.1371/journal.ppat.1005788
https://doi.org/10.1371/journal.ppat.1005788
Autor:
Upkar S Gill, Dimitra Peppa, Lorenzo Micco, Harsimran D Singh, Ivana Carey, Graham R Foster, Mala K Maini, Patrick T F Kennedy
Publikováno v:
PLoS Pathogens, Vol 12, Iss 8, p e1005788 (2016)
NK cells are important antiviral effectors, highly enriched in the liver, with the potential to regulate immunopathogenesis in persistent viral infections. Here we examined whether changes in the NK pool are induced when patients with eAg-positive CH
Externí odkaz:
https://doaj.org/article/9aebe2de77234f2391741401188b7e4c
Autor:
Anna Schurich, Laura J Pallett, Marcin Lubowiecki, Harsimran D Singh, Upkar S Gill, Patrick T Kennedy, Eleni Nastouli, Sudeep Tanwar, William Rosenberg, Mala K Maini
Publikováno v:
PLoS Pathogens, Vol 9, Iss 3, p e1003208 (2013)
Optimal immune activation of naïve CD8 T cells requires signal 1 mediated by the T cell receptor, signal 2 mediated by co-stimulation and signal 3 provided by pro-inflammatory cytokines. However, the potential for signal 3 cytokines to rescue anti-v
Externí odkaz:
https://doaj.org/article/ecbda8d131c8405d80876dbb21268402
Autor:
Gaia Nebbia, Dimitra Peppa, Anna Schurich, Pooja Khanna, Harsimran D Singh, Yang Cheng, William Rosenberg, Geoffrey Dusheiko, Richard Gilson, Joanne ChinAleong, Patrick Kennedy, Mala K Maini
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47648 (2012)
The S-type lectin galectin-9 binds to the negative regulatory molecule Tim-3 on T cells and induces their apoptotic deletion or functional inactivation. We investigated whether galectin-9/Tim-3 interactions contribute to the deletion and exhaustion o
Externí odkaz:
https://doaj.org/article/2616534aec354213b70fe6071ec31027