Výsledky vyhledávání - "Harsimar B. Kaur"

Clonal relationships of adjacent Gleason pattern 3 and Gleason pattern 5 lesions in Gleason Scores 3+5=8 and 5+3=8

Autor: Hasim Bakbak, Erolcan Sayar, Harsimar B. Kaur, Daniela C. Salles, Radhika A. Patel, Jessica Hicks, Tamara L. Lotan, Angelo M. De Marzo, Roman Gulati, Jonathan I. Epstein, Michael C. Haffner

Publikováno v: Human Pathology. 130:18-24

Genomic studies have demonstrated a high level of intra-tumoral heterogeneity in prostate cancer. There is strong evidence suggesting that individual tumor foci can arise as genetically distinct, clonally independent lesions. However, recent studies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f30c2f8a3cb92ec86dede4feff29b4a
https://doi.org/10.1016/j.humpath.2022.10.010

Zobrazit plný text záznamu

Homologous recombination deficiency (HRD) score in germline BRCA2- versus ATM-altered prostate cancer

Autor: Harsimar B. Kaur, Kirsten Timms, Sanjana Murali, Edward M. Schaeffer, Daniela C. Salles, Olivier Cussenot, Robert S. Brown, Geraldine Cancel-Tassin, William B. Isaacs, Emmanuel S. Antonarakis, Tamara L. Lotan, Jerry S. Lanchbury, Andrea L. Richardson

Publikováno v: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

The homologous recombination deficiency (HRD) score integrates three DNA-based measures of genomic instability, and has been understudied in prostate cancer. Given the recent FDA approval of two PARP inhibitors for prostate cancer, HRD score analysis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6de67da26bee656592b7f528616d9a5d
https://doi.org/10.1038/s41379-020-00731-4

Zobrazit plný text záznamu

PIN‐like ductal carcinoma of the prostate has frequent activating RAS/RAF mutations

Autor: Tamara L. Lotan, Harsimar B. Kaur, Jonathan I. Epstein, James R. Eshleman, Adina Paulk, Daniela C. Salles

Publikováno v: Histopathology

AIMS Prostatic intraepithelial neoplasia-like (PIN-like) ductal carcinoma is a rare tumour characterised by often cystically dilated glands architecturally resembling high-grade PIN, but lacking basal cells. These tumours are frequently accompanied b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a8aa0ce46f8ec0a1888d8db62284e1f
https://doi.org/10.1111/his.14224

Zobrazit plný text záznamu

Genomic and Clinicopathologic Characterization ofATM-deficient Prostate Cancer

Autor: Kirsten Timms, Emmanuel S. Antonarakis, Jessica Hicks, Colin C. Pritchard, Bruce J. Trock, Angelo M. De Marzo, Tamara L. Lotan, Daniela C. Salles, Harsimar B. Kaur, William B. Isaacs, Minh Nguyen, Jerry S. Lanchbury, Sanjana Murali

Publikováno v: Clinical Cancer Research. 26:4869-4881

Purpose:The ATM (ataxia telangiectasia mutated) gene is mutated in a subset of prostate cancers, and ATM mutation may confer specific therapeutic vulnerabilities, although ATM-deficient prostate cancers have not been well-characterized.Experimental D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8de327d31e6624bb2979135861899bdf
https://doi.org/10.1158/1078-0432.ccr-20-0764

Zobrazit plný text záznamu

Neuroendocrine differentiation in usual‐type prostatic adenocarcinoma: Molecular characterization and clinical significance

Autor: Iryna Samarska, Jonathan I. Epstein, Tamara L. Lotan, Harsimar B. Kaur, Mohamed Alshalalfa, Edward M. Schaeffer, Sanjana Murali, Jiayun Lu, Benjamin L. Maughan, Emmanuel S. Antonarakis, Corinne E. Joshu, Juan Miguel Mosquera, Farzana A. Faisal, Kaushal Asrani

Publikováno v: Prostate

BACKGROUND Small cell neuroendocrine (NE) carcinomas of the prostate classically lose androgen receptor (AR) expression, may harbor loss of the RB1, TP53, and PTEN tumor suppressor genes, and are associated with a poor prognosis. However usual-type a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8142c179aafca5494bfa53c7bbca5d5c
https://doi.org/10.1002/pros.24035

Zobrazit plný text záznamu

Association between pathogenic germline mutations in BRCA2 and ATM and tumor-infiltrating lymphocytes in primary prostate cancer

Autor: Thiago Vidotto, Harsimar B. Kaur, Daniela C. Salles, Emmanuel S. Antonarakis, William B. Isaacs, Tamara L. Lotan, Adrianna A. Mendes

Publikováno v: Cancer Immunol Immunother

Pathogenic mutations in homologous recombination (HR) DNA repair genes may be associated with increased tumor mutational burden and numbers of tumor-infiltrating lymphocytes (TIL). Though HR-deficient prostate tumors have been anecdotally associated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb4d722df3c005707de7ce11187926c7
https://europepmc.org/articles/PMC9254167/

Zobrazit plný text záznamu

TP53 missense mutation is associated with increased tumor-infiltrating T cells in primary prostate cancer

Autor: Tamara L. Lotan, John R. Barber, Edward M. Schaeffer, Laneisha Maldonado, Angelo M. De Marzo, Corinne E. Joshu, Liana B. Guedes, Mario A. Eisenberger, Jiayun Lu, Harsimar B. Kaur, Scott A. Tomlins, Karen S. Sfanos, Logan Reitz

Publikováno v: Hum Pathol

Summary The makeup of the tumor immune microenvironment may be associated with tumor somatic genomic alterations and plays a key role in tumor progression and response to immunotherapy. We examined the association of tumor-infiltrating T-cell density

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7342d29ae3e93e9af8ac2068facdf689
https://doi.org/10.1016/j.humpath.2019.02.006

Zobrazit plný text záznamu

DNA damage repair alterations are frequent in prostatic adenocarcinomas with focal pleomorphic giant‐cell features

Autor: Abdullah M Alharbi, Harsimar B. Kaur, Tamara L. Lotan, Colin C. Pritchard, Jonathan I. Epstein

Publikováno v: Histopathology

Aims Prostatic adenocarcinomas with focal pleomorphic giant-cell features constitute a rare tumour subtype with abysmal clinical outcomes. More than one-third of patients with this histology die within a year of the initial diagnosis of prostate canc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8019e244cf765654279eddb1f6ea9dfd
https://doi.org/10.1111/his.13806

Zobrazit plný text záznamu

Plný text ve formátu HTML

SPINK1 expression is enriched in African American prostate cancer but is not associated with altered immune infiltration or oncologic outcomes post-prostatectomy

Autor: Jeffrey J. Tosoian, Farzana A. Faisal, Tamara L. Lotan, Harsimar B. Kaur, Scott A. Tomlins, Edward M. Schaeffer

Publikováno v: Prostate Cancer and Prostatic Diseases. 22:552-559

The SPINK1 molecular subtype is more common in African-American (AA) men with prostatic adenocarcinoma (PCa) than European Americans (EA). Studies have suggested that SPINK1 expression is associated with more aggressive disease. However, the size, fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9fe1c8e1eb35151b57fc2702da85c69d
https://doi.org/10.1038/s41391-019-0139-0

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání