Výsledky vyhledávání - "Harshita Khedkar"

Akademický článek

mTOR/EGFR/iNOS/MAP2K1/FGFR/TGFB1 Are Druggable Candidates for N-(2,4-Difluorophenyl)-2′,4′-Difluoro-4-Hydroxybiphenyl-3-Carboxamide (NSC765598), With Consequent Anticancer Implications

Autor: Bashir Lawal, Ching-Yu Lee, Ntlotlang Mokgautsi, Maryam Rachmawati Sumitra, Harshita Khedkar, Alexander T.H. Wu, Hsu-Shan Huang

Publikováno v: Frontiers in Oncology, Vol 11 (2021)

BackgroundThe application of computational and multi-omics approaches has aided our understanding of carcinogenesis and the development of therapeutic strategies. NSC765598 is a novel small molecule derivative of salicylanilide. This study aims to in

Externí odkaz: https://doaj.org/article/4e316418df5b40258273fc203b8b814b

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Akademický článek

Pharmacoinformatics and Preclinical Studies of NSC765690 and NSC765599, Potential STAT3/CDK2/4/6 Inhibitors with Antitumor Activities against NCI60 Human Tumor Cell Lines

Autor: Bashir Lawal, Yen-Lin Liu, Ntlotlang Mokgautsi, Harshita Khedkar, Maryam Rachmawati Sumitra, Alexander T. H. Wu, Hsu-Shan Huang

Publikováno v: Biomedicines, Vol 9, Iss 1, p 92 (2021)

Signal transducer and activator of transcription 3 (STAT3) is a transcriptional regulator of a number of biological processes including cell differentiation, proliferation, survival, and angiogenesis, while cyclin-dependent kinases (CDKs) are a criti

Externí odkaz: https://doaj.org/article/2d77ecc0be4a4debbbd7424030dfec5e

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Deciphering the immuno-pathological role of FLT, and evaluation of a novel dual inhibitor of topoisomerases and mutant-FLT3 for treating leukemia

Autor: Bashir, Lawal, Yu-Cheng, Kuo, Harshita, Khedkar, Ntlotlang, Mokgautsi, Maryam Rachmawati, Sumitra, Alexander Th, Wu, Hsu-Shan, Huang

Publikováno v: American journal of cancer research. 12(11)

Acute myeloid leukemia (AML) is a type of leukemia with an aggressive phenotype, that commonly occurs in adults and with disappointing treatment outcomes. Genetic alterations were implicated in the etiology of cancers and form the basis for defining

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::652498516a88c9b275dc24b2d006849f
https://pubmed.ncbi.nlm.nih.gov/36504887

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Network Pharmacological Analysis through a Bioinformatics Approach of Novel NSC765600 and NSC765691 Compounds as Potential Inhibitors of CCND1/CDK4/PLK1/CD44 in Cancer Types

Autor: Bashir Lawal, Ntlotlang Mokgautsi, Maryam Rachmawati Sumitra, Hsu Shan Huang, Yu-Chi Wang, Harshita Khedkar, Alexander T.H. Wu

Publikováno v: Cancers, Vol 13, Iss 2523, p 2523 (2021)
Cancers
Volume 13
Issue 11

Cyclin D1 (CCND1) and cyclin-dependent kinase 4 (CDK4) both play significant roles in regulating cell cycle progression, while polo-like kinase 1 (PLK1) regulates cell differentiation and tumor progression, and activates cancer stem cells (CSCs), wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0d1980e6c70baaa76f8dadae6dbb81c
https://www.mdpi.com/2072-6694/13/11/2523

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Network Pharmacological Analysis through a Bioinformatics Approach of Novel NSC765600 and NSC765691 Compounds as Potential Inhibitors of

Autor: Ntlotlang, Mokgautsi, Yu-Chi, Wang, Bashir, Lawal, Harshita, Khedkar, Maryam Rachmawati, Sumitra, Alexander T H, Wu, Hsu-Shan, Huang

Publikováno v: Cancers

Simple Summary Around 14 million new cancer cases, rate are reported annually, with high mortality worldswide, several mechanisms are associated with complexities in cancer, which leads to resistance to current therapeutic interventions in cancer pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b5c2a851119cd8fec8adde17b0792168
https://pubmed.ncbi.nlm.nih.gov/34063946

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An Integrated Bioinformatics Study of a Novel Niclosamide Derivative, NSC765689, a Potential GSK3β/β-Catenin/STAT3/CD44 Suppressor with Anti-Glioblastoma Properties

Autor: Ntlotlang Mokgautsi, Bashir Lawal, Alexander T.H. Wu, Harshita Khedkar, Maryam Rachmawati Sumitra, Hsu Shan Huang, Ya Ting Wen

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 2464, p 2464 (2021)
Volume 22
Issue 5

Despite management efforts with standard surgery, radiation, and chemotherapy, glioblastoma multiform (GBM) remains resistant to treatment, which leads to tumor recurrence due to glioma stem cells (GSCs) and therapy resistance. In this study, we used

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb0ff07bef83f2798e01f8c76063f7e6
http://europepmc.org/articles/PMC7957701

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Pharmacoinformatics and Preclinical Studies of NSC765690 and NSC765599, Potential STAT3/CDK2/4/6 Inhibitors with Antitumor Activities against NCI60 Human Tumor Cell Lines

Autor: Harshita Khedkar, Hsu Shan Huang, Ntlotlang Mokgautsi, Maryam Rachmawati Sumitra, Bashir Lawal, Alexander T.H. Wu, Yen Lin Liu

Publikováno v: Biomedicines
Volume 9
Issue 1
Biomedicines, Vol 9, Iss 92, p 92 (2021)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24aef494114c7e560c4adfcd77845976
https://pubmed.ncbi.nlm.nih.gov/33477856

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In-Silico Evaluation of Genetic Alterations in Ovarian Carcinoma and Therapeutic Efficacy of NSC777201, as a Novel Multi-Target Agent for TTK, NEK2, and CDK1

Autor: Hsu Shan Huang, Bashir Lawal, Vijesh Kumar Yadav, Alexander T.H. Wu, Harshita Khedkar, Prateeti Srivastava, Yu-Chi Wang, Ntlotlang Mokgautsi, Maryam Rachmawati Sumitra

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 5895, p 5895 (2021)
Volume 22
Issue 11

Ovarian cancer is often detected at the advanced stages at the time of initial diagnosis. Early-stage diagnosis is difficult due to its asymptomatic nature, where less than 30% of 5-year survival has been noticed. The underlying molecular events asso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ea6eb8357f0c7a47170e0fc783defe6
https://doi.org/10.3390/ijms22115895

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Akademický článek

Network Pharmacological Analysis through a Bioinformatics Approach of Novel NSC765600 and NSC765691 Compounds as Potential Inhibitors of CCND1 / CDK4 / PLK1 / CD44 in Cancer Types.

Autor: Mokgautsi, Ntlotlang^1,2 (AUTHOR) d621108006@tmu.edu.tw, Wang, Yu-Chi³ (AUTHOR) yuchitsgh@mail.ndmctsgh.edu.tw, Lawal, Bashir^1,2 (AUTHOR) d621108004@tmu.edu.tw, Khedkar, Harshita^1,2 (AUTHOR) d621108005@tmu.edu.tw, Sumitra, Maryam Rachmawati^1,2 (AUTHOR) d621109006@tmu.edu.tw, Wu, Alexander T. H.^4,5,6,7 (AUTHOR) chaw1211@tmu.edu.tw, Huang, Hsu-Shan^1,2,7,8,9 (AUTHOR) chaw1211@tmu.edu.tw

Publikováno v: Cancers. Jun2021, Vol. 13 Issue 11, p2523. 1p.

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Akademický článek

An Integrated Bioinformatics Study of a Novel Niclosamide Derivative, NSC765689, a Potential GSK3β / β-Catenin / STAT3 / CD44 Suppressor with Anti-Glioblastoma Properties.

Autor: Mokgautsi, Ntlotlang^1,2 (AUTHOR) d621108006@tmu.edu.tw, Wen, Ya-Ting³ (AUTHOR) 98142@w.tmu.edu.tw, Lawal, Bashir^1,2 (AUTHOR) d621108004@tmu.edu.tw, Khedkar, Harshita^1,2 (AUTHOR) d621108005@tmu.edu.tw, Sumitra, Maryam Rachmawati^1,2 (AUTHOR) maryamrachma60@gmail.com, Wu, Alexander T. H.^4,5,6,7 (AUTHOR) chaw1211@tmu.edu.tw, Huang, Hsu-Shan^1,2,7,8,9 (AUTHOR) chaw1211@tmu.edu.tw

Publikováno v: International Journal of Molecular Sciences. Mar2021, Vol. 22 Issue 5, p2464-2464. 1p.

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