Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Harshita B. Gupta"'
Autor:
Clare E. Murray, Anand V. R. Kornepati, Carlos Ontiveros, Yiji Liao, Bárbara de la Peña Avalos, Cody M. Rogers, Zexuan Liu, Yilun Deng, Haiyan Bai, Suresh Kari, Alvaro S. Padron, Jacob T. Boyd, Ryan Reyes, Curtis A. Clark, Robert S. Svatek, Rong Li, Yanfen Hu, Meiling Wang, José R. Conejo-Garcia, Lauren A. Byers, Kavya Ramkumar, Anil K. Sood, Jung-Min Lee, Christin E. Burd, Ratna K. Vadlamudi, Harshita B. Gupta, Weixing Zhao, Eloïse Dray, Patrick Sung, Tyler J. Curiel
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-24 (2024)
Abstract Background Aside from the canonical role of PDL1 as a tumour surface-expressed immune checkpoint molecule, tumour-intrinsic PDL1 signals regulate non-canonical immunopathological pathways mediating treatment resistance whose significance, me
Externí odkaz:
https://doaj.org/article/324b033e9fa34bbcab45721b8054a03a
Autor:
Deyi Zhang, Ryan M. Reyes, Erica Osta, Suresh Kari, Harshita B. Gupta, Alvaro S. Padron, Anand V. R. Kornepati, Aravind Kancharla, Xiujie Sun, Yilun Deng, Bogang Wu, Ratna Vadlamudi, Rong Li, Robert S. Svatek, Tyler J. Curiel
Publikováno v:
Cancer Medicine, Vol 10, Iss 6, Pp 2137-2152 (2021)
Abstract Tumor cell‐intrinsic programmed death‐ligand 1 (PD‐L1) signals mediate immunopathologic effects in breast, colon, and ovarian cancers and in melanomas, but bladder cancer (BC) effects are unreported. We show here that BC cell‐intrins
Externí odkaz:
https://doaj.org/article/e4a5d1a873db407eb7004100b7129f12
Autor:
Jordan A. Naumann, Prokopios P. Argyris, Michael A. Carpenter, Harshita B. Gupta, Yanjun Chen, Nuri A. Temiz, Yufan Zhou, Cameron Durfee, Joshua Proehl, Brenda L. Koniar, Silvestro G. Conticello, David A. Largaespada, William L. Brown, Hideki Aihara, Rachel I. Vogel, Reuben S. Harris
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 11, p 9305 (2023)
Although the APOBEC3 family of single-stranded DNA cytosine deaminases is well-known for its antiviral factors, these enzymes are rapidly gaining attention as prominent sources of mutation in cancer. APOBEC3′s signature single-base substitutions, C
Externí odkaz:
https://doaj.org/article/ef03e2eadb954f70b563c9dbf4c6b6f9
Autor:
Bogang Wu, Xiujie Sun, Harshita B. Gupta, Bin Yuan, Jingwei Li, Fei Ge, Huai-Chin Chiang, Xiaowen Zhang, Chi Zhang, Deyi Zhang, Jing Yang, Yanfen Hu, Tyler J. Curiel, Rong Li
Publikováno v:
OncoImmunology, Vol 7, Iss 11 (2018)
Programmed death-ligand 1 (PD-L1) and its receptor programmed cell death protein 1 (PD-1) modulate antitumor immunity and are major targets of checkpoint blockade immunotherapy. However, clinical trials of anti-PD-L1 and anti-PD-1 antibodies in breas
Externí odkaz:
https://doaj.org/article/967aa3a780764179b5178d62740cb693
Autor:
Tyler J. Curiel, Ratna Vadlamudi, Rong Li, Vincent Hurez, Kathrin Thedieck, Mary Jo Turk, Yang Liu, Kruthi Murthy, José Conejo-Garcia, Alvaro Padron, Justin M. Drerup, Bin Yuan, Shunhua Lao, Srilakshmi Pandeswara, Gangadhara Sareddy, Harshita B. Gupta, Curtis A. Clark
PD-L1 antibodies produce efficacious clinical responses in diverse human cancers, but the basis for their effects remains unclear, leaving a gap in the understanding of how to rationally leverage therapeutic activity. PD-L1 is widely expressed in tum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::654db7645d5b3a3e69a710be5c177f9f
https://doi.org/10.1158/0008-5472.c.6508806.v1
https://doi.org/10.1158/0008-5472.c.6508806.v1
Autor:
Tyler J. Curiel, Ratna Vadlamudi, Rong Li, Vincent Hurez, Kathrin Thedieck, Mary Jo Turk, Yang Liu, Kruthi Murthy, José Conejo-Garcia, Alvaro Padron, Justin M. Drerup, Bin Yuan, Shunhua Lao, Srilakshmi Pandeswara, Gangadhara Sareddy, Harshita B. Gupta, Curtis A. Clark
Suppl. Fig. 1 confirms that ID8agg is more virulent versus parental ID8 in WT mice. Suppl. Fig. 2 provides relevant details for plasmids used to make recombinant cell lines, and gives Western blot validations for each PD-L1lo clone described. Suppl,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3425089080c9fa577751c54a539adb83
https://doi.org/10.1158/0008-5472.22413750
https://doi.org/10.1158/0008-5472.22413750
Autor:
Haiyan Bai, Alvaro S Padron, Yilun Deng, Yiji J Liao, Clare J Murray, Carlos Ontiveros, Suresh J Kari, Aravind Kancharla, Anand V R Kornepati, Myrna Garcia, Ryan Michael Reyes, Harshita B Gupta, Jose R Conejo-Garcia, Tyler Curiel
Publikováno v:
Journal for ImmunoTherapy of Cancer. 11:e004871
BackgroundTumor intracellular programmed cell death ligand-1 (PDL1) mediates pathologic signals that regulate clinical treatment responses distinctly from surface-expressed PDL1 targeted by αPDL1 immune checkpoint blockade antibodies.MethodsWe perfo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8322ae17119375f7e20f6dd3a8f75a15
https://doi.org/10.1136/jitc-2022-004871
https://doi.org/10.1136/jitc-2022-004871
Autor:
Christian Cervantes, Mustafa Khan, Maria Fernandez, Zexuan Liu, Zainab Hakeem, Suryavathi Viswanadhapalli, Harshita B. Gupta, Tyler J Curiel, Hui Yan, Ratna Vadlamudi, Zhenming Xu
Publikováno v:
The Journal of Immunology. 208:112.11-112.11
The discovery that PD-L1 inhibits PD-1 on CD8+ T cells has led to new mechanistic insights into the regulation of host immune responses. The contribution of PD-L1 expressed by different immune cell types remains poorly understood, partly due to the l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c331cf44f5689e4727c564d3409e08b0
https://doi.org/10.4049/jimmunol.208.supp.112.11
https://doi.org/10.4049/jimmunol.208.supp.112.11
Autor:
Yilun Deng, Justin Michael Drerup, Xinyue Zhang, Ryan M Reyes, Jenny Mendez, Miro E Raeber, Myrna G Garcia, Alvaro S Pardon, Harshita B. Gupta, Onur Boyman, Tyler J Curiel
Publikováno v:
The Journal of Immunology. 206:57.17-57.17
Regulatory T cells (Treg) engage IL-2 by high affinity CD25, and anti-tumor effector T cells (Teff) use intermediate affinity CD122. We studied IL-2 complexes (IL-2c) that selectively activate CD122+ Teff over CD25+ Tregs. We found IL-2c but not aPD-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::898143f4d03a511a85841159ecc263db
https://doi.org/10.4049/jimmunol.206.supp.57.17
https://doi.org/10.4049/jimmunol.206.supp.57.17
Autor:
Anand V Kornepati, Yilun Deng, Eloise Dray, Clare Murray, Suresh C Kari, Erica Osta, Zexuan Liu, Jacob Boyd, Alvaro Padron, Ryan Reyes, Harshita B. Gupta, Curtis A Clark, Rong Li, Weixing Zhao, Ratna Vadlamudi, Patrick Sung, Tyler J. Curiel
Publikováno v:
The Journal of Immunology. 206:67.15-67.15
Tumor PD-L1 mediates non-canonical, intracellular signals including the DNA damage response (DDR), of unclear significance and mechanisms. We show that genetic PD-L1 depletion (PD-L1KO) destabilized the Chk2 protein, a DNA damage response (DDR) facto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc6ed8bfd0cbd2906d19e082016016f8
https://doi.org/10.4049/jimmunol.206.supp.67.15
https://doi.org/10.4049/jimmunol.206.supp.67.15