Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Harshini Neelakantan"'
Autor:
Andrea L. Dimet-Wiley, Christine M. Latham, Camille R. Brightwell, Harshini Neelakantan, Alexander R. Keeble, Nicholas T. Thomas, Haley Noehren, Christopher S. Fry, Stanley J. Watowich
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Human hallmarks of sarcopenia include muscle weakness and a blunted response to exercise. Nicotinamide N-methyltransferase inhibitors (NNMTis) increase strength and promote the regenerative capacity of aged muscle, thus offering a promising
Externí odkaz:
https://doaj.org/article/bd2c80f1e7bf42fd9e877971c7a909b7
Autor:
Andrea Dimet-Wiley, Qinglong Wu, Jerrin T. Wiley, Aditya Eswar, Harshini Neelakantan, Tor Savidge, Stan Watowich
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-18 (2022)
Abstract Treatment with a nicotinamide N-methyltransferase inhibitor (NNMTi; 5-amino-1-methylquinolinium) combined with low-fat diet (LD) promoted dramatic whole-body adiposity and weight loss in diet-induced obese (DIO) mice, rapidly normalizing the
Externí odkaz:
https://doaj.org/article/fd5a732a491e4a779cb2ac5a045ffece
Autor:
Catherine M. Sampson, Andrea L. Dimet, Harshini Neelakantan, Kehinde O. Ogunseye, Heather L. Stevenson, Jonathan D. Hommel, Stanley J. Watowich
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Obesity is a large and growing global health problem with few effective therapies. The present study investigated metabolic and physiological benefits of nicotinamide N-methyltransferase inhibitor (NNMTi) treatment combined with a lean diet
Externí odkaz:
https://doaj.org/article/87f2fa77c3f847f5b4521dfa072c052a
Autor:
Liangsuo Ma, Joel L. Steinberg, Kathryn A. Cunningham, Scott D. Lane, James M. Bjork, Harshini Neelakantan, Amanda E. Price, Ponnada A. Narayana, Thomas R. Kosten, Antoine Bechara, F. Gerard Moeller
Publikováno v:
NeuroImage: Clinical, Vol 7, Iss C, Pp 837-847 (2015)
Cocaine dependence is associated with increased impulsivity in humans. Both cocaine dependence and impulsive behavior are under the regulatory control of cortico-striatal networks. One behavioral laboratory measure of impulsivity is response inhibiti
Externí odkaz:
https://doaj.org/article/1e1adc5022114fb6ad90534c9694479c
Autor:
Christopher S. Fry, Stanley J. Watowich, Camille R. Brightwell, Stanton F. McHardy, Ted G. Graber, Hua Yu Leo Wang, Rosario Maroto, Harshini Neelakantan, John Papaconstantinou
Publikováno v:
Biochem Pharmacol
Aging is accompanied by progressive declines in skeletal muscle mass and strength and impaired regenerative capacity, predisposing older adults to debilitating age-related muscle deteriorations and severe morbidity. Muscle stem cells (muSCs) that pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2e2fcb442be7854f425cd730b6289a1
https://doi.org/10.1016/j.bcp.2019.02.008
https://doi.org/10.1016/j.bcp.2019.02.008
Autor:
Jonathan D. Hommel, Kehinde O. Ogunseye, Catherine M. Sampson, Heather L. Stevenson, Andrea L. Dimet, Stanley J. Watowich, Harshini Neelakantan
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Obesity is a large and growing global health problem with few effective therapies. The present study investigated metabolic and physiological benefits of nicotinamide N-methyltransferase inhibitor (NNMTi) treatment combined with a lean diet substitut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d0a455dd4b0facc100c0edd90ce45cd
https://doi.org/10.1038/s41598-021-85051-6
https://doi.org/10.1038/s41598-021-85051-6
Autor:
Harshini Neelakantan, Lei Wu, Dong Liang, Stanley J. Watowich, Ololade Awosemo, Jing Ma, Diana S.-L. Chow
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 204
5-Amino-1-methyl quinolinium (5-AMQ) is a potent Nicotinamide N-methyl transferase (NNMT) inhibitor. NNMT is an enzyme that catalyzes the N-methylation of the endogenous substrate nicotinamide, as well as exogenous xenobiotics. NNMT is fundamental to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2fb697eb168464474ecad512b391ea0
https://pubmed.ncbi.nlm.nih.gov/34304009
https://pubmed.ncbi.nlm.nih.gov/34304009
Publikováno v:
Experimental and Clinical Psychopharmacology. 24:485-495
This study evaluated the hypothesis that a paclitaxel treatment regimen sufficient to produce mechanical allodynia would alter sensitivities of male and female mice to the conditioned rewarding and reinforcing effects of morphine. Saline or paclitaxe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76bc25baeaae1d8b941e4e986c37a87e
https://doi.org/10.1037/pha0000097
https://doi.org/10.1037/pha0000097
Autor:
Sonja J. Stutz, Haiying Chen, Kathryn A. Cunningham, Joshua D. Snook, Ye Ding, Harshini Neelakantan, Jai S. Rudra, Chunyong Ding, Jia Zhou, Rajagopal Appavu
Publikováno v:
ACS Chemical Neuroscience. 7:546-552
The development of anti-cocaine vaccines that counteract the rewarding effects of the drug are currently being investigated as adjunct therapies for prevention of relapse in abstinent users. However, cocaine is weakly immunogenic and requires conjuga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::007ee1e96cce9f2a46e7305e2c3ec671
https://doi.org/10.1021/acschemneuro.5b00345
https://doi.org/10.1021/acschemneuro.5b00345
Autor:
Harshini Neelakantan, Stan Watowich
Publikováno v:
Diabetes. 67
There is a critical need for new mechanism-of-action drugs that reduce adiposity, a prime driver of type 2 diabetes. A novel target to treat adiposity and reverse type 2 diabetes is nicotinamide-N-methyltransferase (NNMT), a cytosolic enzyme with new
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e5dde04ce957aa31e277d8fc94b04d8
https://doi.org/10.2337/db18-115-lb
https://doi.org/10.2337/db18-115-lb