Pulmonary immunization: deposition site is of minor relevance for influenza vaccination but deep lung deposition is crucial for hepatitis B vaccination

Autor: Jasmine Tomar, Wouter F. Tonnis, Harshad P. Patil, Anne H. de boer, Paul Hagedoorn, Rita Vanbever, Henderik W. Frijlink, Wouter L.J. Hinrichs

Publikováno v: Acta Pharmaceutica Sinica B, Vol 9, Iss 6, Pp 1231-1240 (2019)

Vaccination via the pulmonary route could be an attractive alternative to parenteral administration. Research towards the best site of antigen deposition within the lungs to induce optimal immune responses has conflicting results which might be depen

Externí odkaz: https://doaj.org/article/e79481a79611462b9c54db7a3e21991f

Adjuvantation of Pulmonary-Administered Influenza Vaccine with GPI-0100 Primarily Stimulates Antibody Production and Memory B Cell Proliferation

Autor: Harshad P. Patil, José Herrera Rodriguez, Jacqueline de Vries-Idema, Tjarko Meijerhof, Henderik W. Frijlink, Wouter L. J. Hinrichs, Anke Huckriede

Publikováno v: Vaccines, Vol 5, Iss 3, p 19 (2017)

Adjuvants are key components in vaccines, they help in reducing the required antigen dose but also modulate the phenotype of the induced immune response. We previously showed that GPI-0100, a saponin-derived adjuvant, enhances antigen-specific mucosa

Externí odkaz: https://doaj.org/article/b6b0f2c48095449f8125a519889b7a19

Isolation and genetic characterization of SARS-CoV-2 from Indian patients in a single family without H/O travel abroad

Autor: Akhilesh Chandra Mishra, Sanjay Lalwani, Vidya A. Arankalle, Shubham Shrivastava, Harshad P. Patil, Suhas T. Mhaske, Sonali Palkar

Publikováno v: Virus Genes

In view of the rapidly progressing COVID-19 pandemic, our aim was to isolate and characterize SARS-CoV-2 from Indian patients. SARS-CoV-2 was isolated from nasopharyngeal swabs collected from the two members of a family without any history of (H/O) t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cef8aee573a9f759388b71aaf9e64a3a
https://doi.org/10.1007/s11262-021-01826-z

Evaluation of monophosphoryl lipid A as an adjuvanted for inactivated chikungunya virus

Autor: Mrunal Gosavi, Harshad P. Patil

Publikováno v: Vaccine. 40(34)

Currently there is no clinically approved chikungunya virus (CHIKV) vaccine for immunization. Though definite need is felt, long disappearance of CHIKV has been a concern. Inactivated CHIKV (I-CHIKV) is an attractive antigen to develop effective vacc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::544a8283ef46495b21c6b1e3cf272251
https://pubmed.ncbi.nlm.nih.gov/35871870

Pulmonary immunization

Autor: Rita Vanbever, Anne H. de Boer, Harshad P. Patil, Henderik W. Frijlink, Wouter L. J. Hinrichs, Paul Hagedoorn, Wouter F. Tonnis, Jasmine Tomar

Publikováno v: Acta Pharmaceutica Sinica B, Vol 9, Iss 6, Pp 1231-1240 (2019)
Acta Pharmaceutica Sinica B, 9(6), 1231-1240. Chinese Academy of Medical Sciences
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, (2019)

Vaccination via the pulmonary route could be an attractive alternative to parenteral administration. Research towards the best site of antigen deposition within the lungs to induce optimal immune responses has conflicting results which might be depen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d5a794613c7a9d4d4089e321c0084da
https://hdl.handle.net/11370/5da93227-90e1-4a77-b15a-73f30f1cb5f3