Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Harsha Krovi"'
Autor:
Ivy K Brown, Nathan Dyjack, Mindy M Miller, Harsha Krovi, Cydney Rios, Rachel Woolaver, Laura Harmacek, Ting-Hui Tu, Brian P O'Connor, Thomas Danhorn, Brian Vestal, Laurent Gapin, Clemencia Pinilla, Max A Seibold, James Scott-Browne, Radleigh G Santos, R Lee Reinhardt
Publikováno v:
PLoS Pathogens, Vol 17, Iss 6, p e1009602 (2021)
The CD4+ T cell response is critical to host protection against helminth infection. How this response varies across different hosts and tissues remains an important gap in our understanding. Using IL-4-reporter mice to identify responding CD4+ T cell
Externí odkaz:
https://doaj.org/article/bfee9113d1934b3d8063baf5f57b2905
Autor:
S. Harsha Krovi, Jingjing Zhang, Mary Jessamine Michaels-Foster, Tonya Brunetti, Liyen Loh, James Scott-Browne, Laurent Gapin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Innate-like T cells such as invariant natural killer T (iNKT) and mucosal-associated invariant T (MAIT) cells both develop in the thymus. Here the authors use single-cell RNA sequencing to show that mouse iNKT and MAIT share components of development
Externí odkaz:
https://doaj.org/article/06e13866d71d4727a0acfddef21305ab
Autor:
Kathryn D. Tuttle, S. Harsha Krovi, Jingjing Zhang, Romain Bedel, Laura Harmacek, Lisa K. Peterson, Leonard L. Dragone, Adam Lefferts, Catherine Halluszczak, Kent Riemondy, Jay R. Hesselberth, Anjana Rao, Brian P. O’Connor, Philippa Marrack, James Scott-Browne, Laurent Gapin
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Invariant natural killer T (iNKT) cells can be subsetted by their cytokine profiles, but how they develop in the thymus is unclear. Here the authors show, by analysing mice carrying mutant Zap70 genes, that T cell receptor signaling strength induces
Externí odkaz:
https://doaj.org/article/9d629b4edd534fecb283ec7b354fbbc7
Autor:
Sai Harsha Krovi, Vijay K. Kuchroo
Publikováno v:
Immunol Rev
Autoimmune diseases are characterized by dysfunctional immune systems that misrecognize self as non-self and cause tissue destruction. Several cell types have been implicated in triggering and sustaining disease. Due to a strong association of major
Autor:
Scott B. Thompson, Eric J. Wigton, Sai Harsha Krovi, Jeffrey W. Chung, Robert A. Long, Jordan Jacobelli
Publikováno v:
Frontiers in Oncology, Vol 8 (2018)
Leukemias typically arise in the bone marrow and then spread to the blood and into other tissues. To disseminate into tissues, leukemia cells migrate into the blood stream and then exit the circulation by migrating across vascular endothelial barrier
Externí odkaz:
https://doaj.org/article/afc9c01cb6db49a2b593407fb3cd88a6
Autor:
S. Harsha Krovi, Laurent Gapin
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Invariant natural killer T (iNKT) cells are a CD1d-restricted T cell population that can respond to lipid antigenic stimulation within minutes by secreting a wide variety of cytokines. This broad functional scope has placed iNKT cells at the frontlin
Externí odkaz:
https://doaj.org/article/f3e61e2efc7b4fbe86bd0258ec651d1d
Autor:
Philippa Marrack, Sai Harsha Krovi, Daniel Silberman, Janice White, Eleanor Kushnir, Maki Nakayama, James Crooks, Thomas Danhorn, Sonia Leach, Randy Anselment, James Scott-Browne, Laurent Gapin, John Kappler
Publikováno v:
eLife, Vol 6 (2017)
Mature T cells bearing αβ T cell receptors react with foreign antigens bound to alleles of major histocompatibility complex proteins (MHC) that they were exposed to during their development in the thymus, a phenomenon known as positive selection. T
Externí odkaz:
https://doaj.org/article/79601c2f9b334c868bec5c43366ddd8c
Publikováno v:
Seminars in immunology. 60
Innate T (T
Autor:
Thomas Danhorn, James P. Scott-Browne, Max A. Seibold, Rachel A. Woolaver, R. Lee Reinhardt, Harsha Krovi, Mindy M. Miller, Laurent Gapin, Brian Vestal, Clemencia Pinilla, Cydney Rios, Brian P. O'Connor, Nathan Dyjack, Ivy K Brown, Ting-Hui Tu, Laura Harmacek, Radleigh Santos
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 6, p e1009602 (2021)
PLoS Pathogens, Vol 17, Iss 6, p e1009602 (2021)
The CD4+ T cell response is critical to host protection against helminth infection. How this response varies across different hosts and tissues remains an important gap in our understanding. Using IL-4-reporter mice to identify responding CD4+ T cell
Publikováno v:
Proceedings of the National Academy of Sciences. 116:22252-22261
The repertoire of αβ T cell antigen receptors (TCRs) on mature T cells is selected in the thymus where it is rendered both self-tolerant and restricted to the recognition of major histocompatibility complex molecules presenting peptide antigens (pM