Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Harsha D Devalla"'
Autor:
Alexandra Wiesinger, Jiuru Li, Lianne Fokkert, Priscilla Bakker, Arie O Verkerk, Vincent M Christoffels, Gerard JJ Boink, Harsha D Devalla
Publikováno v:
eLife, Vol 11 (2022)
Each heartbeat is triggered by the sinoatrial node (SAN), the primary pacemaker of the heart. Studies in animal models have revealed that pacemaker cells share a common progenitor with the (pro)epicardium, and that the pacemaker cardiomyocytes furthe
Externí odkaz:
https://doaj.org/article/17bc9b7e4c9f4f619baccc66fec6fcc9
Autor:
Harsha D Devalla, Roselle Gélinas, Elhadi H Aburawi, Abdelaziz Beqqali, Philippe Goyette, Christian Freund, Marie‐A Chaix, Rafik Tadros, Hui Jiang, Antony Le Béchec, Jantine J Monshouwer‐Kloots, Tom Zwetsloot, Georgios Kosmidis, Frédéric Latour, Azadeh Alikashani, Maaike Hoekstra, Jurg Schlaepfer, Christine L Mummery, Brian Stevenson, Zoltan Kutalik, Antoine AF deVries, Léna Rivard, Arthur AM Wilde, Mario Talajic, Arie O Verkerk, Lihadh Al‐Gazali, John D Rioux, Zahurul A Bhuiyan, Robert Passier
Publikováno v:
EMBO Molecular Medicine, Vol 8, Iss 12, Pp 1390-1408 (2016)
Abstract Genetic causes of many familial arrhythmia syndromes remain elusive. In this study, whole‐exome sequencing (WES) was carried out on patients from three different families that presented with life‐threatening arrhythmias and high risk of
Externí odkaz:
https://doaj.org/article/fbd3c37951794a57a006bfdb37a6a0d0
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Atrial fibrillation (AF) is the most common cardiac arrhythmia. About 5–15% of AF patients have a mutation in a cardiac gene, including mutations in KCNA5, encoding the Kv1.5 α-subunit of the ion channel carrying the atrial-specific ultrarapid del
Externí odkaz:
https://doaj.org/article/aa1aa59cfbe9421f97bece334704b108
Autor:
Verena Schwach, Arie O. Verkerk, Mervyn Mol, Jantine J. Monshouwer-Kloots, Harsha D. Devalla, Valeria V. Orlova, Konstantinos Anastassiadis, Christine L. Mummery, Richard P. Davis, Robert Passier
Publikováno v:
Stem Cell Reports, Vol 9, Iss 6, Pp 1765-1779 (2017)
Summary: Reporter cell lines have already proven valuable in identifying, tracking, and purifying cardiac subtypes and progenitors during differentiation of human pluripotent stem cells (hPSCs). We previously showed that chick ovalbumin upstream prom
Externí odkaz:
https://doaj.org/article/86741319e29f4ce69b257080865b7f66
Autor:
Matthew J. Birket, Marcelo C. Ribeiro, Georgios Kosmidis, Dorien Ward, Ana Rita Leitoguinho, Vera van de Pol, Cheryl Dambrot, Harsha D. Devalla, Richard P. Davis, Pier G. Mastroberardino, Douwe E. Atsma, Robert Passier, Christine L. Mummery
Publikováno v:
Cell Reports, Vol 13, Iss 4, Pp 733-745 (2015)
Maximizing baseline function of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) is essential for their effective application in models of cardiac toxicity and disease. Here, we aimed to identify factors that would promote an adequate le
Externí odkaz:
https://doaj.org/article/43333fc490814a07a17c18b2123d6b0b
Autor:
Anthonius de Boer, Gerard J.J. Boink, Patrick C. Souverein, Lixia Jia, Hanno L. Tan, Arie O. Verkerk, Marieke T. Blom, Harsha D. Devalla, Talip E Eroglu
Publikováno v:
British Journal of Clinical Pharmacology
British Journal of Clinical Pharmacology, 87(9), 3588. NLM (Medline)
British journal of clinical pharmacology, 87(9), 3588-3598. Wiley-Blackwell
British Journal of Clinical Pharmacology, 87(9), 3588-3598. Wiley-Blackwell
Eroglu, T E, Jia, L, Blom, M T, Verkerk, A O, Devalla, H D, Boink, G J J, Souverein, P C, de Boer, A & Tan, H L 2021, ' Sulfonylurea antidiabetics are associated with lower risk of out-of-hospital cardiac arrest : Real-world data from a population-based study ', British Journal of Clinical Pharmacology, vol. 87, no. 9, pp. 3588-3598 . https://doi.org/10.1111/bcp.14774
British Journal of Clinical Pharmacology, 87(9), 3588. NLM (Medline)
British journal of clinical pharmacology, 87(9), 3588-3598. Wiley-Blackwell
British Journal of Clinical Pharmacology, 87(9), 3588-3598. Wiley-Blackwell
Eroglu, T E, Jia, L, Blom, M T, Verkerk, A O, Devalla, H D, Boink, G J J, Souverein, P C, de Boer, A & Tan, H L 2021, ' Sulfonylurea antidiabetics are associated with lower risk of out-of-hospital cardiac arrest : Real-world data from a population-based study ', British Journal of Clinical Pharmacology, vol. 87, no. 9, pp. 3588-3598 . https://doi.org/10.1111/bcp.14774
Aims Out-of-hospital cardiac arrest (OHCA) mostly results from ventricular tachycardia/ventricular fibrillation (VT/VF), often triggered by acute myocardial infarction (AMI). Sulfonylurea (SU) antidiabetics can block myocardial ATP-regulated K+ chann
Autor:
Matthias S. Roost, Liesbeth van Iperen, Yavuz Ariyurek, Henk P. Buermans, Wibowo Arindrarto, Harsha D. Devalla, Robert Passier, Christine L. Mummery, Françoise Carlotti, Eelco J.P. de Koning, Erik W. van Zwet, Jelle J. Goeman, Susana M. Chuva de Sousa Lopes
Publikováno v:
Stem Cell Reports, Vol 4, Iss 6, Pp 1112-1124 (2015)
Differentiated derivatives of human pluripotent stem cells in culture are generally phenotypically immature compared to their adult counterparts. Their identity is often difficult to determine with certainty because little is known about their human
Externí odkaz:
https://doaj.org/article/984f0c77ca5649fba29f84474cb4b634
Autor:
Alexandra Wiesinger, Jiuru Li, Lianne Fokkert, Priscilla Bakker, Arie O Verkerk, Vincent M Christoffels, Gerard JJ Boink, Harsha D Devalla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c55349d1c3a52c4c65081c1e04501f35
https://doi.org/10.7554/elife.76781.sa2
https://doi.org/10.7554/elife.76781.sa2
Autor:
Jiuru Li, Alexandra Wiesinger, Lianne Fokkert, Bastiaan J. Boukens, Arie O. Verkerk, Vincent M. Christoffels, Gerard J.J. Boink, Harsha D. Devalla
Publikováno v:
Journal of Tissue Engineering
Journal of Tissue Engineering, 13. SAGE-Hindawi Access to Research
Journal of Tissue Engineering, 13. SAGE-Hindawi Access to Research
Paucity of physiologically relevant cardiac models has limited the widespread application of human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes in drug development. Here, we performed comprehensive characterization of hiPSC-derived ca
Autor:
Alexandra Wiesinger, Jiuru Li, Lianne Fokkert, Priscilla Bakker, Arie O. Verkerk, Vincent M. Christoffels, Gerard J.J. Boink, Harsha D. Devalla
Each heartbeat is triggered by the sinoatrial node, the natural pacemaker of the heart. Animal models have revealed that pacemaker cells share a common progenitor with the (pro)epicardium, and that the pacemaker cardiomyocytes further diversify into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::afe0e99abde858785b1698af922201ba
https://doi.org/10.1101/2021.12.28.474383
https://doi.org/10.1101/2021.12.28.474383