Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Harsh Sancheti"'
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract High-fat diet (HFD)-induced obesity is accompanied by insulin resistance and compromised brain synaptic plasticity through the impairment of insulin-sensitive pathways regulating neuronal survival, learning, and memory. Lipoic acid is known
Externí odkaz:
https://doaj.org/article/00abb3e70d59446397a7d5cea45acd64
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0204043 (2018)
Insulin resistance-as observed in aging, diabetes, obesity, and other pathophysiological situations, affects brain function, for insulin signaling is responsible for neuronal glucose transport and control of energy homeostasis and is involved in the
Externí odkaz:
https://doaj.org/article/8b1358831bc5440cb7c88ef3284607cd
Autor:
Zhigang Liu, Ishan Y Patil, Tianyi Jiang, Harsh Sancheti, John P Walsh, Bangyan L Stiles, Fei Yin, Enrique Cadenas
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0128274 (2015)
High-fat diet (HFD)-induced obesity is associated with insulin resistance, which may affect brain synaptic plasticity through impairment of insulin-sensitive processes underlying neuronal survival, learning, and memory. The experimental model consist
Externí odkaz:
https://doaj.org/article/1be50d6f8b234e90a4405d08238056f9
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69830 (2013)
Alzheimer's disease is a progressive neurodegenerative disease that entails impairments of memory, thinking and behavior and culminates into brain atrophy. Impaired glucose uptake (accumulating into energy deficits) and synaptic plasticity have been
Externí odkaz:
https://doaj.org/article/0e6598008b4b40c39c77629847470b9b
Autor:
Harsh Sancheti, Heather S. Johnson, Enrique Cadenas, Madhuri P. Rao, Gary G. Martin, Neil Kaplowitz, Carl W. Decker, Derick Han, Kai H. Silkwood, Kim Tho Nguyen, Joseph G. Casian
Publikováno v:
Free Radical Biology and Medicine. 102:100-110
The feeding of alcohol orally (Lieber-DeCarli diet) to rats has been shown to cause declines in mitochondrial respiration (state III), decreased expression of respiratory complexes, and decreased respiratory control ratios (RCR) in liver mitochondria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::462f572afa5339301b27ae600930fa2f
https://doi.org/10.1016/j.freeradbiomed.2016.11.020
https://doi.org/10.1016/j.freeradbiomed.2016.11.020
Publikováno v:
The Journal of Physiology. 594:2025-2042
Mitochondrial dysfunction entailing decreased energy-transducing capacity and perturbed redox homeostasis is an early and sometimes initiating event in ageing and age-related disorders involving tissues with high metabolic rate such as brain, liver a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54e186e8ce9d49eb9492a56147c9d55e
https://doi.org/10.1113/jp270541
https://doi.org/10.1113/jp270541
Autor:
Tao Feng, Todd E. Morgan, Enrique Cadenas, Harsh Sancheti, Wendy J. Mack, Fei Yin, Jia Yao, Roberta Diaz Brinton, Christian J. Pike, Caleb E. Finch, Roberto Cosimo Melcangi
Publikováno v:
Neurobiology of Aging. 36:2282-2295
The perimenopause is an aging transition unique to the female that leads to reproductive senescence which can be characterized by multiple neurological symptoms. To better understand potential underlying mechanisms of neurological symptoms of perimen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa4b039b42cfa4c106231f0eaa12c315
https://doi.org/10.1016/j.neurobiolaging.2015.03.013
https://doi.org/10.1016/j.neurobiolaging.2015.03.013
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
High-fat diet (HFD)-induced obesity is accompanied by insulin resistance and compromised brain synaptic plasticity through the impairment of insulin-sensitive pathways regulating neuronal survival, learning, and memory. Lipoic acid is known to modula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98033d60f31e7f6036bd9434e2d80855
http://europepmc.org/articles/PMC5511189
http://europepmc.org/articles/PMC5511189
Publikováno v:
Free radical biologymedicine. 100
The high energy demand of the brain renders it sensitive to changes in energy fuel supply and mitochondrial function. Deficits in glucose availability and mitochondrial function are well-known hallmarks of brain aging and are particularly accentuated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e5bf612b8227a76af1f8f2d1c6c1037
https://pubmed.ncbi.nlm.nih.gov/27154981
https://pubmed.ncbi.nlm.nih.gov/27154981
Publikováno v:
Antioxidants & Redox Signaling. 17:1714-1727
Significance: Regulation of mitochondrial H2O2 homeostasis and its involvement in the regulation of redox-sensitive signaling and transcriptional pathways is the consequence of the concerted activities of the mitochondrial energy- and redox systems.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45b8502cbfd6752f908d7b2d28876695
https://doi.org/10.1089/ars.2012.4639
https://doi.org/10.1089/ars.2012.4639