Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Harrys K.C Jacob"'
Autor:
Bhuwan Giri, Prateek Sharma, Tejeshwar Jain, Anthony Ferrantella, Utpreksha Vaish, Siddharth Mehra, Bharti Garg, Srikanth Iyer, Vrishketan Sethi, Zoe Malchiodi, Rossana Signorelli, Harrys K.C Jacob, John George, Preeti Sahay, Ejas P. Bava, Rajinder Dawra, Sundaram Ramakrishnan, Ashok Saluja, Vikas Dudeja
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
Heat shock protein 70 (Hsp70), a protein chaperone, is known to promote cell survival and tumor progression. However, its role in the tumor microenvironment (TME) is largely unknown. We specifically evaluated Hsp70 in the TME by implanting tumors in
Externí odkaz:
https://doaj.org/article/786c93290f6148c7ab4cff987558f4d1
Autor:
Guillem Paniagua, Harrys K.C. Jacob, Oksana Brehey, Sara García‐Alonso, Carmen G. Lechuga, Tirso Pons, Monica Musteanu, Carmen Guerra, Matthias Drosten, Mariano Barbacid
Publikováno v:
Molecular Oncology, Vol 16, Iss 17, Pp 3066-3081 (2022)
The kinase suppressor of rat sarcoma (RAS) proteins (KSR1 and KSR2) have long been considered as scaffolding proteins required for optimal mitogen‐activated protein kinase (MAPK) pathway signalling. However, recent evidence suggests that they play
Externí odkaz:
https://doaj.org/article/34f5097f0f0941118de6acfad756e9f3
Autor:
Mariano Barbacid, Carmen Guerra, Xosé R. Bustelo, Nicoletta Potenza, Salvatore Fabbiano, Harrys K.C. Jacob, María T. Blasco, Carmen G. Lechuga, Isabel Hernández-Porras, Lucía Simón-Carrasco, Matthias Drosten
Supplementary Figure S1. Generation of conditional knock-in mice that express the H-RasG12V oncoprotein from the K-Ras locus. Supplementary Figure S2. Flow cytometry analysis of myeloid cell expansion in spleens and BM of H-RasG12V expressing mice. S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45ac27a8dc194123871c76b3477e92a8
https://doi.org/10.1158/0008-5472.22414041
https://doi.org/10.1158/0008-5472.22414041
Autor:
Mariano Barbacid, Carmen Guerra, Xosé R. Bustelo, Nicoletta Potenza, Salvatore Fabbiano, Harrys K.C. Jacob, María T. Blasco, Carmen G. Lechuga, Isabel Hernández-Porras, Lucía Simón-Carrasco, Matthias Drosten
Genetic studies in mice have provided evidence that H-Ras and K-Ras proteins are bioequivalent. However, human tumors display marked differences in the association of RAS oncogenes with tumor type. Thus, to further assess the bioequivalence of oncoge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc93e3985cab387761980e1aaaef9af2
https://doi.org/10.1158/0008-5472.c.6508872
https://doi.org/10.1158/0008-5472.c.6508872
Autor:
Mariano Barbacid, Carmen Guerra, Xosé R. Bustelo, Nicoletta Potenza, Salvatore Fabbiano, Harrys K.C. Jacob, María T. Blasco, Carmen G. Lechuga, Isabel Hernández-Porras, Lucía Simón-Carrasco, Matthias Drosten
Supplementary Methods and Supplementary Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ef7433cc7cb4acc3610f6a0cec6a01a
https://doi.org/10.1158/0008-5472.22414038
https://doi.org/10.1158/0008-5472.22414038
Autor:
null Guillem Paniagua, null Harrys K.C. Jacob, null Oksana Brehey, null Sara García‐Alonso, null Carmen G. Lechuga, null Tirso Pons, null Monica Musteanu, null Carmen Guerra, null Matthias Drosten, null Mariano Barbacid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c962c5b2e53e6949af3d4eab951c8a87
https://doi.org/10.1002/1878-0261.13213/v3/response1
https://doi.org/10.1002/1878-0261.13213/v3/response1
Autor:
Beatriz Gomez Aguilar, Srikanth Iyer, Prateek Sharma, Ejas Palathingal Bava, Vrishketan Sethi, Ashok K. Saluja, Tejeshwar Jain, Utpreksha Vaish, Harrys K.C. Jacob, Preeti Sahay, Mohammad Tarique, Dujon B. Edwards, Rajinder Dawra, Vikas Dudeja, Bhuwan Giri, Craig L. Maynard, John George, Anthony Ferrantella
Publikováno v:
JCI Insight. 7
Despite decades of research there is no specific therapy for Acute Pancreatitis (AP). In the current study, we have evaluated the efficacy of pirfenidone, an anti-inflammatory and anti-fibrotic agent which is FDA-approved for treatment of idiopathic
Autor:
Bharti Garg, Ashok K. Saluja, Ejas Palathingal Bava, Vrishketan Sethi, Preeti Sahay, Zoe X. Malchiodi, Harrys K.C. Jacob, John George, Rossana Signorelli, Tejeshwar Jain, Siddharth Mehra, Anthony Ferrantella, Sundaram Ramakrishnan, Srikanth Iyer, Rajinder Dawra, Bhuwan Giri, Vikas Dudeja, Prateek Sharma, Utpreksha Vaish
Publikováno v:
Oncoimmunology
article-version (VoR) Version of Record
OncoImmunology, Vol 10, Iss 1 (2021)
article-version (VoR) Version of Record
OncoImmunology, Vol 10, Iss 1 (2021)
Heat shock protein 70 (Hsp70), a protein chaperone, is known to promote cell survival and tumor progression. However, its role in the tumor microenvironment (TME) is largely unknown. We specifically evaluated Hsp70 in the TME by implanting tumors in
Autor:
Sulagna Banerjee, Harrys K.C. Jacob
Publikováno v:
Gastroenterology
BACKGROUND & AIMS: Intraductal papillary mucinous neoplasms (IPMNs) are lesions that can progress to invasive pancreatic cancer and an important system for studies of pancreatic tumorigenesis. We performed comprehensive genomic analyses of entire IPM
Autor:
Rossana Signorelli, Tyler Kashuv, Harrys K.C. Jacob, Ranjitha Boopathy, Utpreksha Vaish, Ashok K. Saluja, Vikas Dudeja, Shweta Lavania, Ashley Middleton, John Lalith Charles Richard, Melinda Minucci Boone, Ramakrishnan Sundaram
Publikováno v:
Cancers
Cancers, Vol 13, Iss 2727, p 2727 (2021)
Volume 13
Issue 11
Cancers, Vol 13, Iss 2727, p 2727 (2021)
Volume 13
Issue 11
Tumor cells dissociate from the primary site and enter into systemic circulation (circulating tumor cells, CTCs) either alone or as tumor microemboli (clusters)
the latter having an increased predisposition towards forming distal metastases than
the latter having an increased predisposition towards forming distal metastases than