Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Harry S. Courtney"'
Autor:
Harry S. Courtney, Itzhak Ofek, Thomas Penfound, Victor Nizet, Morgan A. Pence, Bernd Kreikemeyer, Andreas Podbielski, David L. Hasty, James B. Dale
Publikováno v:
PLoS ONE, Vol 4, Iss 1 (2009)
Externí odkaz:
https://doaj.org/article/5adb688430b447458f8f6c432144f0c3
Autor:
Harry S Courtney, Itzhak Ofek, Thomas Penfound, Victor Nizet, Morgan A Pence, Bernd Kreikemeyer, Andreas Podbielski, David L Hasty, James B Dale
Publikováno v:
PLoS ONE, Vol 4, Iss 1, p e4166 (2009)
BackgroundHydrophobicity is an important attribute of bacteria that contributes to adhesion and biofilm formation. Hydrophobicity of Streptococcus pyogenes is primarily due to lipoteichoic acid (LTA) on the streptococcal surface but the mechanism(s)
Externí odkaz:
https://doaj.org/article/c25d60e84c374d7ea659406e8a7a68d0
Autor:
Harry S. Courtney, Joel M Berretta, Warren O. Haggard, Mark S. Smeltzer, Karen E. Beenken, Jessica A. Jennings
Publikováno v:
Clinical Orthopaedics & Related Research. 475:1857-1870
Local drug delivery devices offer a promising method for delivering vancomycin and amikacin for musculoskeletal wounds. However, current local delivery devices such as beads and sponges do not necessarily allow for full coverage of a wound surface wi
Autor:
James B. Dale, Claudia M. Hohn, Shannon E. Niedermeyer, Thomas A. Penfound, Adam Greeley, Harry S. Courtney
Publikováno v:
Clinical and Experimental Vaccine Research
Purpose There is a need to broaden protective coverage of M protein-based vaccines against group A streptococci (GAS) because coverage of the current 30-valent M protein vaccine does not extend to all emm types. An additional GAS antigen and virulenc
Autor:
Jessica A. Jennings, Heather A. Doty, Warren O. Haggard, Harry S. Courtney, Joel D. Bumgardner
Publikováno v:
Biomaterials and Biomechanics in Bioengineering. 2:159-172
Treatment of polymicrobial infected musculoskeletal defects continues to be a challenge in orthopaedics. This research investigated single and dual-delivery of two antibiotics, vancomycin and amikacin, targeting different classes of microorganism fro
Autor:
Warren O. Haggard, Karen E. Beenken, Karen S. Troxel, Jessica A. Jennings, Mark S. Smeltzer, Harry S. Courtney, Daniel P. Carpenter
Publikováno v:
Clinical Orthopaedics & Related Research. 473:2270-2282
Orthopaedic biomaterials are susceptible to biofilm formation. A novel lipid-based material has been developed that may be loaded with antibiotics and applied as an implant coating at point of care. However, this material has not been evaluated for a
Autor:
Yvette Del Rosario, Czarinah Paco, Rong Mu, Harry S. Courtney, Kelly S. Doran, Brandon J. Kim
Publikováno v:
Infection and Immunity. 82:2276-2286
Group B Streptococcus (GBS) is currently the leading cause of neonatal meningitis. This is due to its ability to survive and multiply in the bloodstream and interact with specialized human brain microvascular endothelial cells (hBMEC), which constitu
Autor:
Claudia M. Hohn, Harry S. Courtney, Jerome Baudry, Pierre R. Smeesters, James B. Dale, Jeremy C. Smith, Thomas A. Penfound
Publikováno v:
Vaccine. 35(1)
Background A major obstacle to the development of broadly protective M protein-based group A streptococcal (GAS) vaccines is the variability within the N-terminal epitopes that evoke potent bactericidal antibodies. The concept of M type-specific prot
Autor:
J. Amber Jennings, Harry S. Courtney, Joel M Berretta, Cheyenne S Rhodes, Christopher Alexander, Mark S. Smeltzer, Karen E Beenken, Joel D. Bumgardner, Warren O. Haggard
Publikováno v:
World Journal of Orthopedics
AIM To investigate the efficacy of a chitosan/polyethylene glycol blended paste as a local antibiotic delivery device, particularly in musculoskeletal wounds. METHODS Acidic (A) chitosan sponges and neutralized (N) chitosan/polyethylene glycol (PEG)
Autor:
Joel D. Bumgardner, Warren O. Haggard, Harry S. Courtney, Jessica A. Jennings, Ernö Lindner, A. Parker
Publikováno v:
Journal of Biomedical Materials Research Part B: Applied Biomaterials. :110-123
Local versus systemic antibiotic delivery may be an effective strategy for treating musculoskeletal infections, especially when antibiotic-resistant bacteria are present. Lyophilized uncrosslinked, genipin crosslinked, and genipin crosslinked with po