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Akademický článek

DNA mismatch repair defect and intratumor heterogeneous deficiency differently impact immune responses in diffuse large B-cell lymphoma

Publikováno v: OncoImmunology, Vol 13, Iss 1 (2024)

Deficient (d) DNA mismatch repair (MMR) is a biomarker predictive of better response to PD-1 blockade immunotherapy in solid tumors. dMMR can be caused by mutations in MMR genes or by protein inactivation, which can be detected by sequencing and immu

Externí odkaz: https://doaj.org/article/5de2138da31648e09e4ad55f932a3cf2

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Akademický článek

Targeting a STING agonist to perivascular macrophages in prostate tumors delays resistance to androgen deprivation therapy

Autor: Christopher Bailey, Johann De Bono, Munitta Muthana, Mateus Crespo, Bora Gurel, Pasquale Rescigno, Matthew Fisher, Wayne A Phillips, Richard Allen, Harry Nunns, Janet E Brown, Haider Al-janabi, Katy Moyes, Anna Junker-Jensen, Helen B Pearson, Mary-Ellen Taplin, Claire E Lewis

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 12, Iss 7 (2024)

Background Androgen deprivation therapy (ADT) is a front-line treatment for prostate cancer. In some men, their tumors can become refractory leading to the development of castration-resistant prostate cancer (CRPC). This causes tumors to regrow and m

Externí odkaz: https://doaj.org/article/2f9585a571b74710badae3f4850ddc0f

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Akademický článek

Changes in the immune landscape of TNBC after neoadjuvant chemotherapy: correlation with relapse

Autor: Mohammed Ridha Moamin, Richard Allen, Steven Leslie Woods, Janet Elizabeth Brown, Harry Nunns, Anna Juncker-Jensen, Claire Elizabeth Lewis

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

IntroductionPatients with high-risk, triple negative breast cancer (TNBC) often receive neoadjuvant chemotherapy (NAC) alone or with immunotherapy. Various single-cell and spatially resolved techniques have demonstrated heterogeneity in the phenotype

Externí odkaz: https://doaj.org/article/90b65a0739274753b52ec5008c0fc1b9

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Akademický článek

Genomic complexity is associated with epigenetic regulator mutations and poor prognosis in diffuse large B-cell lymphoma

Publikováno v: OncoImmunology, Vol 10, Iss 1 (2021)

Diffuse large B-cell lymphoma (DLBCL) is the most common type of lymphoma with high mutation burdens but a low response rate to immune checkpoint inhibitors. In this study, we performed targeted next-generation sequencing and fluorescent multiplex im

Externí odkaz: https://doaj.org/article/4cc601ce935d46d6bdaa5d24f1fab423

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Akademický článek

Signaling pathways as linear transmitters

Autor: Harry Nunns, Lea Goentoro

Publikováno v: eLife, Vol 7 (2018)

One challenge in biology is to make sense of the complexity of biological networks. A good system to approach this is signaling pathways, whose well-characterized molecular details allow us to relate the internal processes of each pathway to their in

Externí odkaz: https://doaj.org/article/ec2ae0dc325a414481c8c7c183eaf0a5

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