Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Harry Nisén"'
Autor:
Moon Hee Lee, Essi Laajala, Anna Kreutzman, Petrus Järvinen, Harry Nísen, Tuomas Mirtti, Maija Hollmén, Satu Mustjoki
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Renal cell carcinoma (RCC) accounts for 90% of all renal cancers and is considered highly immunogenic. Although many studies have reported the circulating peripheral cytokine profiles, the signatures between the tumor tissue and matching hea
Externí odkaz:
https://doaj.org/article/4a93417b438340b78c35c73444c21f35
Autor:
Moon Hee Lee, Petrus Järvinen, Harry Nísen, Oscar Brück, Mette Ilander, Ilona Uski, Jason Theodoropoulos, Matti Kankainen, Tuomas Mirtti, Satu Mustjoki, Anna Kreutzman
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
Renal cell carcinoma (RCC) is considered as an immunogenic cancer. Because not all patients respond to current immunotherapies, we aimed to investigate the immunological heterogeneity of RCC tumors. We analyzedthe immunophenotype of the circulating,
Externí odkaz:
https://doaj.org/article/1532d0f16bb447e093cf3ccc83e2be64
Autor:
Kalle E. Mattila, Teemu D. Laajala, Sara V. Tornberg, Tuomas P. Kilpeläinen, Paula Vainio, Otto Ettala, Peter J. Boström, Harry Nisen, Laura L. Elo, Panu M. Jaakkola
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract After surgery of localized renal cell carcinoma, over 20% of the patients will develop distant metastases. Our aim was to develop an easy-to-use prognostic model for predicting metastasis-free survival after radical or partial nephrectomy of
Externí odkaz:
https://doaj.org/article/f097036ba65447a59e243f07da006031
Autor:
Sara Feola, Manlio Fusciello, Beatriz Martins, Erkko Ylösmäki, Vincenzo Cerullo, Firas Hamdan, Jacopo Chiaro, Yvonne Giannoula, Maeve Long, Michaela Feodoroff, Gabriella Antignani, Salvatore Russo, Otto Kari, Petrus Järvinen, Harry Nisen, Anna Kreutzman, Satu Mustjoki, Thomas G McWilliams, Mikaela Grönholm, Moon Hee Lee
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 8 (2021)
Background Despite the success of immune checkpoint inhibitors against PD-L1 in the clinic, only a fraction of patients benefit from such therapy. A theoretical strategy to increase efficacy would be to arm such antibodies with Fc-mediated effector m
Externí odkaz:
https://doaj.org/article/75228aef30a64c3b90f489f356c51753
Autor:
Victor Cervera-Carrascon, Dafne C.A. Quixabeira, Joao Manuel Santos, Riikka Havunen, Sadia Zafar, Otto Hemminki, Camilla Heiniö, Eleonora Munaro, Mikko Siurala, Suvi Sorsa, Tuomas Mirtti, Petrus Järvinen, Markus Mildh, Harry Nisen, Antti Rannikko, Marjukka Anttila, Anna Kanerva, Akseli Hemminki
Publikováno v:
OncoImmunology, Vol 9, Iss 1 (2020)
Checkpoint inhibitors have revolutionized cancer therapy and validated immunotherapy as an approach. Unfortunately, responses are seen in a minority of patients. Our objective is to use engineered adenoviruses designed to increase lymphocyte traffick
Externí odkaz:
https://doaj.org/article/427bcd24283e4f45b2cfc17fdcf816b7
Autor:
Lassi Luomala, Kalle Mattila, Paula Vainio, Harry Nisén, Teijo Pellinen, Jouni Lohi, Teemu D. Laajala, Petrus Järvinen, Anna‐Riina Koskenniemi, Panu Jaakkola, Tuomas Mirtti
Publikováno v:
Cancer Medicine, Vol 13, Iss 3, Pp n/a-n/a (2024)
Abstract Background Hypoxia inducible factors, HIF‐1α and HIF‐2α, and their main regulators, the prolyl hydroxylase domain proteins (PHDs), mediate cellular response to hypoxia and contribute to tumor progression in clear cell renal cell carcin
Externí odkaz:
https://doaj.org/article/c03724c045a9453491bfbda1ba93dc88
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-7 (2022)
Abstract There may be surgical overtreatment of complex cystic renal masses (CRM). Growing evidence supports active surveillance (AS) for the management for Bosniak IIF–III CRMs. We aimed to evaluate and compare oncological and pathological outcome
Externí odkaz:
https://doaj.org/article/d8763d0634124bdba81686152755f656
Publikováno v:
Duodecim; laaketieteellinen aikakauskirja. 132(16)
The incidence of small nephromas of less than four centimeters in size has increased over the past decades with the increasing number of imaging studies. The majority of these tumors are kidney cancers exhibiting large variation in their aggressivene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4607209d7d0d51e0f5546fc0794078a3
https://pubmed.ncbi.nlm.nih.gov/29188704
https://pubmed.ncbi.nlm.nih.gov/29188704
Autor:
Rim Bouslama, Vincent Dumont, Sonja Lindfors, Lassi Paavolainen, Jukka Tienari, Harry Nisen, Tuomas Mirtti, Moin A. Saleem, Daniel Gordin, Per-Henrik Groop, Shiro Suetsugu, Sanna Lehtonen
Publikováno v:
Cells, Vol 12, Iss 11, p 1487 (2023)
Changes in the dynamic architecture of podocytes, the glomerular epithelial cells, lead to kidney dysfunction. Previous studies on protein kinase C and casein kinase 2 substrates in neurons 2 (PACSIN2), a known regulator of endocytosis and cytoskelet
Externí odkaz:
https://doaj.org/article/051c46658c344b7d80aa86068b022ab4