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pro vyhledávání: '"Harry N White"'
Autor:
Harry N White
Publikováno v:
Viruses, Vol 13, Iss 4, p 565 (2021)
A central feature of vertebrate immune systems is the ability to form antigen-specific immune memory in response to microbial challenge and so provide protection against future infection. In conflict with this process is the ability that many viruses
Externí odkaz:
https://doaj.org/article/70dd4ef160684977b16ac4b3f6f577c5
Autor:
Bronwen R Burton, Richard K Tennant, John Love, Richard W Titball, David C Wraith, Harry N White
Publikováno v:
eLife, Vol 7 (2018)
Vaccines induce memory B-cells that provide high affinity secondary antibody responses to identical antigens. Memory B-cells can also re-instigate affinity maturation, but how this happens against antigenic variants is poorly understood despite its p
Externí odkaz:
https://doaj.org/article/7ff664d7460643c98acaea77787e8bda
Publikováno v:
Immunology
Summary Designing improved vaccines against mutable viruses such as dengue and influenza would be helped by a better understanding of how the B‐cell memory compartment responds to variant antigens. Towards this we have recently shown, after seconda
A powerful vaccine against mutable viruses might induce memory antibodies that either strongly bound antigenic variants or that could rapidly undergo secondary affinity maturation to achieve this. We have recently shown after secondary immunization o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c4f09ad2d608683138d1ed41893a455
https://doi.org/10.1101/438184
https://doi.org/10.1101/438184
Autor:
Richard W. Titball, Richard K. Tennant, Bronwen R Burton, Harry N White, David C. Wraith, John Love
Publikováno v:
eLife, Vol 7 (2018)
eLife
Burton, B 2018, ' Variant proteins stimulate more IgM+ GC B-cells revealing a mechanism of cross-reactive recognition by antibody memory ', eLife, vol. 7, e26832 . https://doi.org/10.7554/eLife.26832
eLife
Burton, B 2018, ' Variant proteins stimulate more IgM+ GC B-cells revealing a mechanism of cross-reactive recognition by antibody memory ', eLife, vol. 7, e26832 . https://doi.org/10.7554/eLife.26832
Vaccines induce memory B-cells that provide high affinity secondary antibody responses to identical antigens. Memory B-cells can also re-instigate affinity maturation, but how this happens against antigenic variants is poorly understood despite its p
Autor:
Qing-Hai, Meng, Harry N, White
Publikováno v:
Immunology
Summary CD21int CD23+ IgM+ mouse follicular B cells comprise the bulk of the mature B‐cell compartment, but it is not known whether these cells contribute to the humoral antibody response. We show using a direct RT‐PCR method for antigen‐specif
Autor:
Roland J. Levinsky, Kimberly Gilmour, Manfred Schmidt, Joanna Sinclair, John L. Smith, Abdulaziz Al Ghonaium, H. Bobby Gaspar, Marianne Antonius Jakobsen, Christine Kinnon, Kathryn L. Parsley, Doug King, Christof von Kalle, Torben Barington, Robin R. Ali, Harry N White, Gaby Brouns, Hans Ole Christensen, Adrian J. Thrasher, Steven J. Howe
Publikováno v:
The Lancet. 364:2181-2187
X-linked severe combined immunodeficiency (SCID-X1) is caused by mutations in the common cytokine-receptor gamma chain (gamma(c)), resulting in disruption of development of T lymphocytes and natural-killer cells. B-lymphocyte function is also intrins
Autor:
P Woo, David C. Linch, Rachel Jeffery, Anand Patel, Hemlata Varsani, Lucy R. Wedderburn, Harry N White, K. J. Murray
Publikováno v:
Rheumatology. 40:1299-1307
We have studied immune reconstitution in a patient with paediatric-onset polyarteritis nodosa treated with high-dose immunosuppressive agents followed by stem cell rescue. The patient developed several new autoimmune phenomena over the 18 months afte
Autor:
Harry N White, Zadie Davis, Freda K. Stevenson, David Goldblatt, Helen Baxendale, M B Spellerberg
Publikováno v:
European Journal of Immunology. 30:1214-1223
Pneumococcal serotype-specific anti-capsular polysaccharide antibodies protect against invasive pneumococcal disease. Within an individual the diversity of these antibodies is limited. To evaluate the repertoire of antibodies to pneumococcus and dete