Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Harry Mager"'
Autor:
Harry Mager, Gernot Göller
Publikováno v:
Journal of Pharmaceutical Sciences. 87:372-378
Toxicokinetic studies often require destructive sampling and the determination of drug concentrations in the various organs. Classically, the corresponding information is summarized in one mean concentration-time profile, which is regarded as represe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb0b980577cfd8db1c9cf65551cffea3
https://doi.org/10.1021/js970114h
https://doi.org/10.1021/js970114h
Autor:
Erich Sander, Eberhard Karbe, E. Bomhard, Harry Mager, H.J. Ahr, Gerhard Schlüter, Harald Enzmann
Publikováno v:
Cardiovascular Drugs and Therapy. 12:157-169
The preclinical evidence for a potential influence of calcium channel blockers (CCBs) on carcinogenesis is discussed in the light of a broad database from rodent carcinogenicity studies as well as literature data. In all bioassays performed in rats a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6641a615b187236be28f79707cb94acf
https://doi.org/10.1023/a:1007727010076
https://doi.org/10.1023/a:1007727010076
Autor:
Gernot Göller, Harry Mager
Publikováno v:
Drug Information Journal. 31:551-562
This paper provides a brief review of the properties shared by chemical kinetics, clinical pharmacokinetics, and toxicokinetics and on where they differ. The special situation of toxicokinetics and some methods for estimating secondary pharmacokineti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::990f3581466eaa9ea9b61392e0d324eb
https://doi.org/10.1177/009286159703100223
https://doi.org/10.1177/009286159703100223
Autor:
Gernot Göller, Harry Mager
Publikováno v:
Statistics in Medicine. 14:1009-1024
In general, the pharmacokinetic model parameters, like rate constants, area under the curve (AUC) etc. are estimated via a two-stage procedure, where the values obtained from concentration-time relationships within one subject (experimental unit) are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::109368001b60c0b761841fbe0dcb5c06
https://doi.org/10.1002/sim.4780140920
https://doi.org/10.1002/sim.4780140920
Autor:
Harry Mager, Peter P. Mager
Publikováno v:
Quantitative Structure-Activity Relationships. 11:518-521
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62444a7a26b1ea074893d7b6a4deed96
https://doi.org/10.1002/qsar.2660110409
https://doi.org/10.1002/qsar.2660110409
Autor:
Harry Mager
Publikováno v:
Advances in Quantative Structure-Property Relationships Volume 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc5595243fac2116554eba0b69b4557e
https://doi.org/10.1016/s1874-527x(96)80007-7
https://doi.org/10.1016/s1874-527x(96)80007-7
Autor:
Harry Mager
Publikováno v:
Quantitative Structure-Activity Relationships. 3:147-153
Cross-validation methods in which a portion of the data is used to estimate the model coefficients, and the remainder of the data is used to measure the prediction accuracy of the model are of outstanding significance in QSAR work. The concept of dat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b6a153e3316913c43b664b401f75369
https://doi.org/10.1002/qsar.19840030405
https://doi.org/10.1002/qsar.19840030405