Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Harry M. Olson"'
Publikováno v:
Toxicological Sciences. 34:5-14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4746c25167a751ba6dea51ae2c3ecd37
https://doi.org/10.1093/toxsci/34.1.5
https://doi.org/10.1093/toxsci/34.1.5
Publikováno v:
Toxicology letters.
This project was undertaken by the International Life Sciences Institute's Health and Environmental Sciences Institute (ILSI-HESI) to develop an improved understanding of the extent to which various types of human toxicities (HTs) manifested during c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f03fa1d626b83dcfd8250e5400686f6
https://pubmed.ncbi.nlm.nih.gov/10022308
https://pubmed.ncbi.nlm.nih.gov/10022308
Autor:
Harry M Olson, Jack H Dean
Publikováno v:
Biology of the cell. 77(1)
Summary Integrating toxicology early in the drug discovery process adds value by providing the earliest possible identification of a compound's potential for toxicological and pathological effects relevant to intended clinical use. With this approach
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16109ced86cfe8e65bde172c9fc5711d
https://pubmed.ncbi.nlm.nih.gov/8518743
https://pubmed.ncbi.nlm.nih.gov/8518743
Autor:
Charles C. Capen, Harry M. Olson
Publikováno v:
Cardiovascular and Musculoskeletal Systems ISBN: 9783642765353
Initiation and development of osteosarcomas in rats inoculated into the tibia with a standard viral preparation of Moloney sarcoma virus at 1 day of age (less than 24 h old) is observed as early as 10–12 days after injection. Initially, a small rad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::362d0bcfab7eada227bb3412d7954e51
https://doi.org/10.1007/978-3-642-76533-9_29
https://doi.org/10.1007/978-3-642-76533-9_29
Publikováno v:
JNCI: Journal of the National Cancer Institute. 55:191-194
After one dose of adriamycin, a subacute cardiomyopathy was observed in the mouse by both light and electron microscopy. The microscopic alterations were characterized by single-cell necrosis and mitochondrial degeneration. These lesions were similar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4599a168bd7554b12a57f885617ae19
https://doi.org/10.1093/jnci/55.1.191
https://doi.org/10.1093/jnci/55.1.191
Autor:
Charles C. Capen, Harry M. Olson
Publikováno v:
JNCI: Journal of the National Cancer Institute. 58:433-437
Osteosarcomas were induced in approximately 80% of young New Zealand Black rats by the intratibial inoculation of Moloney murine sarcoma virus from day 1 to day 5 after birth. The neoplasms were composed of a spectrum of well-differentiated to poorly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83b84cf9649ee568a09d1e597f367b51
https://doi.org/10.1093/jnci/58.2.433
https://doi.org/10.1093/jnci/58.2.433
Autor:
Charles C. Capen, Harry M. Olson
Publikováno v:
Toxicology and Applied Pharmacology. 44:605-616
A cardiotoxic response similar to that occurring with chronic doxorubicin (Adriamycin, ADR) administration in man and rabbits has been produced in the new Zealand Black (NZB) rat. ADR was given by the iv or ip route in groups of rats at 2 mg/kg/week
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c970a39f758c569b348f475ffe80ebe
https://doi.org/10.1016/0041-008x(78)90268-5
https://doi.org/10.1016/0041-008x(78)90268-5
Publikováno v:
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 144(2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d28366b868b15b382516b165397d5a5d
https://pubmed.ncbi.nlm.nih.gov/4746944
https://pubmed.ncbi.nlm.nih.gov/4746944