Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Harry M Greenblatt"'
Publikováno v:
Nucleic Acids Research.
In eukaryotes, many DNA/RNA-binding proteins possess intrinsically disordered regions (IDRs) with large negative charge, some of which involve a consecutive sequence of aspartate (D) or glutamate (E) residues. We refer to them as D/E repeats. The fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34d0e6a90d222c25c261c76c7832aed7
https://doi.org/10.1093/nar/gkad045
https://doi.org/10.1093/nar/gkad045
Publikováno v:
Biochemistry
DNA mismatch repair (MMR) is an important postreplication process that eliminates mispaired or unpaired nucleotides to ensure genomic replication fidelity. In humans, Msh2-Msh6 and Msh2-Msh3 are the two mismatch repair initiation factors that recogni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89182b5606082700d8779f2f8e698bd7
http://europepmc.org/articles/PMC7872316
http://europepmc.org/articles/PMC7872316
Autor:
Michael Katz, Ron Diskin, Hadas Cohen-Dvashi, Harry M. Greenblatt, Anastasiya Shulman, Yaakov Levy
Publikováno v:
Journal of Molecular Biology. 431:2095-2111
Lassa virus (LASV) is a notorious human pathogen in West Africa. Its class I trimeric spike complex displays a distinct architecture, and its cell entry mechanism involves unique attributes not shared by other related viruses. We determined the cryst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52cfa53fee8d2b98c0f5dff6c73c1c3c
https://doi.org/10.1016/j.jmb.2019.04.012
https://doi.org/10.1016/j.jmb.2019.04.012
Autor:
Binhan Yu, Lavi S. Bigman, Yaakov Levy, Channing C. Pletka, Junji Iwahara, Xi Wang, Harry M. Greenblatt
Publikováno v:
J Mol Biol
Highly negatively charged segments containing only aspartate or glutamate residues (“D/E repeats”) are found in many eukaryotic proteins. For example, the C-terminal 30 residues of the HMGB1 protein are entirely D/E repeats. Using nuclear magneti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3dfa23f5ad0868f985970e31ad3fe66
https://pubmed.ncbi.nlm.nih.gov/34181980
https://pubmed.ncbi.nlm.nih.gov/34181980
Publikováno v:
The Journal of Physical Chemistry. B
DNA-binding proteins rely on linear diffusion along the longitudinal DNA axis, supported by their nonspecific electrostatic affinity for DNA, to search for their target recognition sites. One may therefore expect that the ability to engage in linear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaac25f57feeac16af242c4c4866a54d
https://pubmed.ncbi.nlm.nih.gov/33754737
https://pubmed.ncbi.nlm.nih.gov/33754737
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-3 (2020)
Nature Communications
Nature Communications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36fee6f446b1cbbc314249443c9522c5
https://doi.org/10.1038/s41467-020-18855-1
https://doi.org/10.1038/s41467-020-18855-1
Publikováno v:
Nucleic Acids Research
Several DNA-binding proteins, such as topoisomerases, helicases and sliding clamps, have a toroidal (i.e. ring) shape that topologically traps DNA, with this quality being essential to their function. Many DNA-binding proteins that function, for exam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e601fbac12a02882a2b987f153d39c6f
https://doi.org/10.1093/nar/gky436
https://doi.org/10.1093/nar/gky436
Publikováno v:
The Journal of Physical Chemistry Letters. 6:3572-3577
Glycosylation plays not only a functional role but can also modify the biophysical properties of the modified protein. Usually, natural glycosylation results in protein stabilization; however, in vitro and in silico studies showed that sometimes glyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62fc0d4f93436b81ebfb8570fb4dce9d
https://doi.org/10.1021/acs.jpclett.5b01588
https://doi.org/10.1021/acs.jpclett.5b01588
Autor:
Melanie G. Kirkpatrick, Susan G. Brown, Joel L. Sussman, Harry M. Greenblatt, George W. Buchman, Elena S. Kovaleva, Tamara C. Otto, Douglas M. Cerasoli
Publikováno v:
Acta Crystallographica Section F Structural Biology and Crystallization Communications. 68:269-272
The use of whole insect larvae as a source of recombinant proteins offers a more cost-effective method of producing large quantities of human proteins than conventional cell-culture approaches. Human carboxylesterase 1 has been produced in and isolat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7a8b434b9061d607ec928699e633b4e
https://doi.org/10.1107/s1744309112003326
https://doi.org/10.1107/s1744309112003326
Autor:
Florian Nachon, Patrick Masson, Marie-Thérèse Froment, Israel Silman, Benoît Sanson, Martin Weik, Jacques-Philippe Colletier, Lilly Toker, Yaacov Ashani, Harry M. Greenblatt, Joel L. Sussman
Publikováno v:
Journal of Medicinal Chemistry. 52:7593-7603
Organophosphate compounds (OP) are potent inhibitors of acetylcholinesterases (AChEs) and can cause lethal poisoning in humans. Inhibition of AChEs by the OP soman involves phosphonylation of the catalytic serine, and subsequent dealkylation produces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dec696c55f9211c73bd57bbf0d7284b
https://doi.org/10.1021/jm900433t
https://doi.org/10.1021/jm900433t