Zobrazeno 1 - 10
of 356
pro vyhledávání: '"Harry L T Mobley"'
Autor:
Harry L T Mobley, Mark T Anderson, Bridget S Moricz, Geoffrey B Severin, Caitlyn L Holmes, Elizabeth N Ottosen, Tad Eichler, Surbhi Gupta, Santosh Paudel, Ritam Sinha, Sophia Mason, Stephanie D Himpsl, Aric N Brown, Margaret Gaca, Christina M Kiser, Thomas H Clarke, Derrick E Fouts, Victor J DiRita, Michael A Bachman
Publikováno v:
PLoS Pathogens, Vol 20, Iss 8, p e1012495 (2024)
There is a critical gap in knowledge about how Gram-negative bacterial pathogens, using survival strategies developed for other niches, cause lethal bacteremia. Facultative anaerobic species of the Enterobacterales order are the most common cause of
Externí odkaz:
https://doaj.org/article/790cb40716724b9980c96102427a6fde
Autor:
Mark T Anderson, Stephanie D Himpsl, Lindsay A Mitchell, Leandra G Kingsley, Elizabeth P Snider, Harry L T Mobley
Publikováno v:
PLoS Pathogens, Vol 18, Iss 3, p e1010423 (2022)
Serratia marcescens is a versatile opportunistic pathogen that can cause a variety of infections, including bacteremia. Our previous work established that the capsule polysaccharide (CPS) biosynthesis and translocation locus contributes to the surviv
Externí odkaz:
https://doaj.org/article/7096f0dbe46d4182beaf3659cbfe5336
Autor:
Laura A Mike, Andrew J Stark, Valerie S Forsyth, Jay Vornhagen, Sara N Smith, Michael A Bachman, Harry L T Mobley
Publikováno v:
PLoS Pathogens, Vol 17, Iss 3, p e1009376 (2021)
Hypervirulent K. pneumoniae (hvKp) is a distinct pathotype that causes invasive community-acquired infections in healthy individuals. Hypermucoviscosity (hmv) is a major phenotype associated with hvKp characterized by copious capsule production and p
Externí odkaz:
https://doaj.org/article/9c527e2000c44b9c93b2cdaf8183b5c6
Autor:
Wangshu Jiang, Wimal Ubhayasekera, Michael C Breed, Allison N Norsworthy, Nina Serr, Harry L T Mobley, Melanie M Pearson, Stefan D Knight
Publikováno v:
PLoS Pathogens, Vol 16, Iss 8, p e1008707 (2020)
Proteus mirabilis, a Gram-negative uropathogen, is a major causative agent in catheter-associated urinary tract infections (CAUTI). Mannose-resistant Proteus-like fimbriae (MR/P) are crucially important for P. mirabilis infectivity and are required f
Externí odkaz:
https://doaj.org/article/fd82efa38e6245fdb58119c198e16692
Autor:
Stephanie D Himpsl, Allyson E Shea, Jonathan Zora, Jolie A Stocki, Dannielle Foreman, Christopher J Alteri, Harry L T Mobley
Publikováno v:
PLoS Pathogens, Vol 16, Iss 2, p e1008382 (2020)
The energy required for a bacterium to grow and colonize the host is generated by metabolic and respiratory functions of the cell. Proton motive force, produced by these processes, drives cellular mechanisms including redox balance, membrane potentia
Externí odkaz:
https://doaj.org/article/412617a5ad7c4f62b2dc303ce0f68b5d
Autor:
Jay Vornhagen, Yuang Sun, Paul Breen, Valerie Forsyth, Lili Zhao, Harry L T Mobley, Michael A Bachman
Publikováno v:
PLoS Pathogens, Vol 15, Iss 8, p e1008010 (2019)
Klebsiella pneumoniae (Kp), one of the most common causes of healthcare-associated infections, increases patient morbidity, mortality, and hospitalization costs. Kp must acquire nutrients from the host for successful infection; however, the host is a
Externí odkaz:
https://doaj.org/article/a36a514dc4da4de5afb137ec3baa90d1
Autor:
Chelsie E Armbruster, Valerie S Forsyth, Alexandra O Johnson, Sara N Smith, Ashley N White, Aimee L Brauer, Brian S Learman, Lili Zhao, Weisheng Wu, Mark T Anderson, Michael A Bachman, Harry L T Mobley
Publikováno v:
PLoS Pathogens, Vol 15, Iss 4, p e1007653 (2019)
The Gram-negative bacterium Proteus mirabilis is a common cause of catheter-associated urinary tract infections (CAUTI), which can progress to secondary bacteremia. While numerous studies have investigated experimental infection with P. mirabilis in
Externí odkaz:
https://doaj.org/article/3b1cfff69ee54e98a7399e8f7df5af4c
Autor:
Christopher J Alteri, Stephanie D Himpsl, Kevin Zhu, Haley L Hershey, Ninette Musili, Jessa E Miller, Harry L T Mobley
Publikováno v:
PLoS Pathogens, Vol 13, Iss 11, p e1006729 (2017)
Type VI secretion systems (T6SS) function to deliver lethal payloads into target cells. Many studies have shown that protection against a single, lethal T6SS effector protein requires a cognate antidote immunity protein, both of which are often encod
Externí odkaz:
https://doaj.org/article/cdf4bb52acc4429c951fedd0ed7525f0
Autor:
Chelsie E Armbruster, Valerie Forsyth-DeOrnellas, Alexandra O Johnson, Sara N Smith, Lili Zhao, Weisheng Wu, Harry L T Mobley
Publikováno v:
PLoS Pathogens, Vol 13, Iss 6, p e1006434 (2017)
The Gram-negative bacterium Proteus mirabilis is a leading cause of catheter-associated urinary tract infections (CAUTIs), which are often polymicrobial. Numerous prior studies have uncovered virulence factors for P. mirabilis pathogenicity in a muri
Externí odkaz:
https://doaj.org/article/b07668fdcd7542e18be917316ffaf268
Publikováno v:
PLoS Pathogens, Vol 11, Iss 1, p e1004601 (2015)
The human genitourinary tract is a common anatomical niche for polymicrobial infection and a leading site for the development of bacteremia and sepsis. Most uncomplicated, community-acquired urinary tract infections (UTI) are caused by Escherichia co
Externí odkaz:
https://doaj.org/article/1428afe358594ba8959542cd2d2d5f2d