Zobrazeno 1 - 10
of 519
pro vyhledávání: '"Harry L T Mobley"'
Autor:
Harry L T Mobley, Mark T Anderson, Bridget S Moricz, Geoffrey B Severin, Caitlyn L Holmes, Elizabeth N Ottosen, Tad Eichler, Surbhi Gupta, Santosh Paudel, Ritam Sinha, Sophia Mason, Stephanie D Himpsl, Aric N Brown, Margaret Gaca, Christina M Kiser, Thomas H Clarke, Derrick E Fouts, Victor J DiRita, Michael A Bachman
Publikováno v:
PLoS Pathogens, Vol 20, Iss 8, p e1012495 (2024)
There is a critical gap in knowledge about how Gram-negative bacterial pathogens, using survival strategies developed for other niches, cause lethal bacteremia. Facultative anaerobic species of the Enterobacterales order are the most common cause of
Externí odkaz:
https://doaj.org/article/790cb40716724b9980c96102427a6fde
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT Gram-negative facultative anaerobes often cause bacteremia, a systemic infection associated with severe clinical outcomes. ArcAB, a two-component regulatory system that represses aerobic respiration, is a key mediator of metabolic adaptation
Externí odkaz:
https://doaj.org/article/db3186dd667640c39d947e61d0da2980
Autor:
Saroj Khadka, Brooke E. Ring, Ryan S. Walker, Lindsey R. Krzeminski, Drew A. Pariseau, Matthew Hathaway, Harry L. T. Mobley, Laura A. Mike
Publikováno v:
mSphere, Vol 8, Iss 5 (2023)
ABSTRACT Klebsiella pneumoniae is a hospital-associated pathogen primarily causing urinary tract infections (UTIs), pneumonia, and septicemia. Two challenging lineages include the hypervirulent strains, causing invasive community-acquired infections,
Externí odkaz:
https://doaj.org/article/2a39f57885284225b954598023adf05c
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 6 (2022)
ABSTRACT Ordered transposon libraries are a valuable resource for many bacterial species, especially those with difficult methods for generating targeted genetic mutations. Here, we present the construction of an ordered transposon library for the ba
Externí odkaz:
https://doaj.org/article/86e0f6610b2049aebecdd188d6732406
Autor:
Arwen E. Frick-Cheng, Anna Sintsova, Sara N. Smith, Ali Pirani, Evan S. Snitkin, Harry L. T. Mobley
Publikováno v:
mBio, Vol 13, Iss 3 (2022)
ABSTRACT More than half of women will experience a urinary tract infection (UTI), with uropathogenic Escherichia coli (UPEC) causing ~80% of uncomplicated cases. Iron acquisition systems are essential for uropathogenesis, and UPEC strains encode high
Externí odkaz:
https://doaj.org/article/44c625d9a85448c6b49a3823b1ef5635
Autor:
Kate R. Fortney, Sara N. Smith, Julia J. van Rensburg, Julie A. Brothwell, Jessi J. Gardner, Barry P. Katz, Nagib Ahsan, Adam S. Duerfeldt, Harry L. T. Mobley, Stanley M. Spinola
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 2 (2022)
ABSTRACT CpxRA is an envelope stress response system that is highly conserved in the Enterobacteriaceae. CpxA has kinase activity for CpxR and phosphatase activity for phospho-CpxR (CpxR-P), a transcription factor. In response to membrane stress, Cpx
Externí odkaz:
https://doaj.org/article/b2d258c8b6db425cba994f2c24fac80d
Autor:
Mark T Anderson, Stephanie D Himpsl, Lindsay A Mitchell, Leandra G Kingsley, Elizabeth P Snider, Harry L T Mobley
Publikováno v:
PLoS Pathogens, Vol 18, Iss 3, p e1010423 (2022)
Serratia marcescens is a versatile opportunistic pathogen that can cause a variety of infections, including bacteremia. Our previous work established that the capsule polysaccharide (CPS) biosynthesis and translocation locus contributes to the surviv
Externí odkaz:
https://doaj.org/article/7096f0dbe46d4182beaf3659cbfe5336
Autor:
Mark T. Anderson, Aric N. Brown, Ali Pirani, Sara N. Smith, Amanda L. Photenhauer, Yuang Sun, Evan S. Snitkin, Michael A. Bachman, Harry L. T. Mobley
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
ABSTRACT Bloodstream infections (BSI) are a major public health burden due to high mortality rates and the cost of treatment. The impact of BSI is further compounded by a rise in antibiotic resistance among Gram-negative species associated with these
Externí odkaz:
https://doaj.org/article/ddd4a91eb3004209a0e9be83e9243df5
Autor:
Laura A Mike, Andrew J Stark, Valerie S Forsyth, Jay Vornhagen, Sara N Smith, Michael A Bachman, Harry L T Mobley
Publikováno v:
PLoS Pathogens, Vol 17, Iss 3, p e1009376 (2021)
Hypervirulent K. pneumoniae (hvKp) is a distinct pathotype that causes invasive community-acquired infections in healthy individuals. Hypermucoviscosity (hmv) is a major phenotype associated with hvKp characterized by copious capsule production and p
Externí odkaz:
https://doaj.org/article/9c527e2000c44b9c93b2cdaf8183b5c6
Autor:
Wangshu Jiang, Wimal Ubhayasekera, Michael C Breed, Allison N Norsworthy, Nina Serr, Harry L T Mobley, Melanie M Pearson, Stefan D Knight
Publikováno v:
PLoS Pathogens, Vol 16, Iss 8, p e1008707 (2020)
Proteus mirabilis, a Gram-negative uropathogen, is a major causative agent in catheter-associated urinary tract infections (CAUTI). Mannose-resistant Proteus-like fimbriae (MR/P) are crucially important for P. mirabilis infectivity and are required f
Externí odkaz:
https://doaj.org/article/fd82efa38e6245fdb58119c198e16692