Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Harry J. Whitwell"'
Autor:
Nicole Trainor, Harry J. Whitwell, Beatriz Jiménez, Katie Addison, Emily Leonidou, Peter A. DiMaggio, Matthew J. Fuchter
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-7 (2024)
Abstract Epigenetic processes influence health and disease through mechanisms which alter gene expression. In contrast to genetic changes which affect DNA sequences, epigenetic marks include DNA base modifications or post-translational modification (
Externí odkaz:
https://doaj.org/article/87335fc7f7724a2092e84a1f9df73312
Autor:
Nuno R. Nené, Alexander Ney, Tatiana Nazarenko, Oleg Blyuss, Harvey E. Johnston, Harry J. Whitwell, Eva Sedlak, Aleksandra Gentry-Maharaj, Sophia Apostolidou, Eithne Costello, William Greenhalf, Ian Jacobs, Usha Menon, Justin Hsuan, Stephen P. Pereira, Alexey Zaikin, John F. Timms
Publikováno v:
Communications Medicine, Vol 3, Iss 1, Pp 1-14 (2023)
Nené et al. construct machine learning models based on serum protein biomarker data to detect pancreatic ductal adenocarcinoma in a nested case-control study from the UKCTOCS cohort. Their ensemble modelling approach outperforms existing combination
Externí odkaz:
https://doaj.org/article/7cece6036b8243379037823c6a8d4e33
Autor:
Alexander J. Ainscough, Timothy J. Smith, Maike Haensel, Christopher J. Rhodes, Adam Fellows, Harry J. Whitwell, Eleni Vasilaki, Kelly Gray, Adrian Freeman, Luke S. Howard, John Wharton, Benjamin Dunmore, Paul D. Upton, Martin R. Wilkins, Joshua B. Edel, Beata Wojciak-Stothard
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
A biomimetic inducible model of pulmonary arterial hypertension (PAH) is presented, combining natural and induced BMPR2 dysfunction with hypoxia in lung endothelial cells and blood-derived PAH cells to induce smooth muscle activation & proliferation.
Externí odkaz:
https://doaj.org/article/23b65781f0864f158a058def624a88d9
Autor:
Vadim Demichev, Pinkus Tober-Lau, Tatiana Nazarenko, Oliver Lemke, Simran Kaur Aulakh, Harry J. Whitwell, Annika Röhl, Anja Freiwald, Mirja Mittermaier, Lukasz Szyrwiel, Daniela Ludwig, Clara Correia-Melo, Lena J. Lippert, Elisa T. Helbig, Paula Stubbemann, Nadine Olk, Charlotte Thibeault, Nana-Maria Grüning, Oleg Blyuss, Spyros Vernardis, Matthew White, Christoph B. Messner, Michael Joannidis, Thomas Sonnweber, Sebastian J. Klein, Alex Pizzini, Yvonne Wohlfarter, Sabina Sahanic, Richard Hilbe, Benedikt Schaefer, Sonja Wagner, Felix Machleidt, Carmen Garcia, Christoph Ruwwe-Glösenkamp, Tilman Lingscheid, Laure Bosquillon de Jarcy, Miriam S. Stegemann, Moritz Pfeiffer, Linda Jürgens, Sophy Denker, Daniel Zickler, Claudia Spies, Andreas Edel, Nils B. Müller, Philipp Enghard, Aleksej Zelezniak, Rosa Bellmann-Weiler, Günter Weiss, Archie Campbell, Caroline Hayward, David J. Porteous, Riccardo E. Marioni, Alexander Uhrig, Heinz Zoller, Judith Löffler-Ragg, Markus A. Keller, Ivan Tancevski, John F. Timms, Alexey Zaikin, Stefan Hippenstiel, Michael Ramharter, Holger Müller-Redetzky, Martin Witzenrath, Norbert Suttorp, Kathryn Lilley, Michael Mülleder, Leif Erik Sander, Florian Kurth, Markus Ralser
Publikováno v:
PLOS Digital Health, Vol 1, Iss 1 (2022)
Global healthcare systems are challenged by the COVID-19 pandemic. There is a need to optimize allocation of treatment and resources in intensive care, as clinically established risk assessments such as SOFA and APACHE II scores show only limited per
Externí odkaz:
https://doaj.org/article/ca9c7a2e20b1488b8dd4b7e2dbf10ad7
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Parenclitic networks provide a powerful and relatively new way to coerce multidimensional data into a graph form, enabling the application of graph theory to evaluate features. Different algorithms have been published for constructing parenclitic net
Externí odkaz:
https://doaj.org/article/ec9d7cbb8a034b1d9972ecfdb59090a5
Autor:
Harry J. Whitwell, Maria Giulia Bacalini, Oleg Blyuss, Shangbin Chen, Paolo Garagnani, Susan Yu Gordleeva, Sarika Jalan, Mikhail Ivanchenko, Oleg Kanakov, Valentina Kustikova, Ines P. Mariño, Iosif Meyerov, Ekkehard Ullner, Claudio Franceschi, Alexey Zaikin
Publikováno v:
Frontiers in Aging Neuroscience, Vol 12 (2020)
Biological aging is a complex process involving multiple biological processes. These can be understood theoretically though considering them as individual networks—e.g., epigenetic networks, cell-cell networks (such as astroglial networks), and pop
Externí odkaz:
https://doaj.org/article/039b5d79b83f4355bb48fbe7f3ae3b2a
Autor:
Shibu Krishnan, Harry J. Whitwell, Joy Cuenco, Aleksandra Gentry-Maharaj, Usha Menon, Stephen P. Pereira, Marco Gaspari, John F. Timms
Publikováno v:
International Journal of Molecular Sciences, Vol 18, Iss 12, p 2670 (2017)
Biomarkers for the early detection of pancreatic cancer are urgently needed. The aim of this pilot study was to evaluate changes in serum N-glycoproteins and their glycosylation status prior to clinical presentation of pancreatic cancer that may be p
Externí odkaz:
https://doaj.org/article/60388bddca554cdf89d6a2ac885d4ece
Autor:
Anna M. Kowalka, Kleopatra Alexiadou, Joyceline Cuenco, Rosemary E. Clarke, Stephane Camuzeaux, James Minnion, Emma L. Williams, Paul Bech, Sanjay Purkayastha, Ahmed R. Ahmed, Zoltan Takats, Bernard Khoo, Harry J. Whitwell, Maria G. Romero, Stephen R. Bloom, Matthew R. Lewis, Tricia M.‐M. Tan
Publikováno v:
Clinical Endocrinology. 98:763-765
Autor:
Ho Kwong Li, Xiangyun Zhi, Ana Vieira, Harry J. Whitwell, Amelia Schricker, Elita Jauneikaite, Hanqi Li, Ahmed Yosef, Ivan Andrew, Laurence Game, Claire E. Turner, Theresa Lamagni, Juliana Coelho, Shiranee Sriskandan
Publikováno v:
Microbial Genomics. 9
Streptococcus pyogenes genotype emm1 is a successful, globally distributed epidemic clone that is regarded as inherently virulent. An emm1 sublineage, M1UK, that produces increased levels of SpeA toxin was associated with increased scarlet fever and
Autor:
Ho Kwong Li, Xiangyun Zhi, Ana Vieira, Harry J Whitwell, Amelia Schricker, Elita Jauneikaite, Hanqi Li, Ahmed Yosef, Ivan Andrew, Laurence Game, Claire E. Turner, Theresa Lamagni, Juliana Coelho, Shiranee Sriskandan
Emm1Streptococcus pyogenesis a successful, globally-distributed epidemic clone that is regarded as inherently invasive. Anemm1 sublineage, M1UK, that expresses increased SpeA toxin, was associated with increased scarlet fever and invasive infections
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2ce7e0e8ae4f394735d427b254aa89f
https://doi.org/10.1101/2022.12.27.522030
https://doi.org/10.1101/2022.12.27.522030