Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Harry J. Gould"'
Autor:
Steven D. Scahill, Kelly Jean Sherman, Jessie J. Guidry, Whitney Walkowski, Theresa Nguyen, Durwood B. Ray, David H. Jones, Harry J. Gould, III, Dennis Paul
Publikováno v:
Advances in Cancer Biology - Metastasis, Vol 7, Iss , Pp 100101- (2023)
To evaluate a potentially valuable tool to study cancer progression and metastasis, we characterized a novel murine model composed of a parental oncogene-transformed embryonic fibroblast line and five cell lines isolated from progressively advanced t
Externí odkaz:
https://doaj.org/article/09ef3146b0a846429b53ae3fd4abef97
Autor:
Harry J. Gould, Paige R. Miller, Samantha Edenfield, Kelly Jean Sherman, Chad K. Brady, Dennis Paul
Publikováno v:
Current Oncology, Vol 28, Iss 3, Pp 2115-2122 (2021)
Upregulation of voltage-gated sodium channels (VGSCs) and Na+/K+-ATPase (sodium pumps) is common across most malignant carcinomas. Targeted osmotic lysis (TOL) is a developing technology in which the concomitant stimulation of VGSCs and pharmacologic
Externí odkaz:
https://doaj.org/article/34690d1de6b64c57b9ebf0d43ee732a4
Autor:
Harry J. Gould, Samantha Edenfield, Paige R. Miller, Kelly Jean Sherman, Brian Melius, Alissa Whitney, Robert P. Hunter, Fabio Del Piero, Dennis Tracey, Dennis Paul
Publikováno v:
Case Reports in Veterinary Medicine, Vol 2022 (2022)
Background. Targeted osmotic lysis (TOL) is a novel technology that involves concomitant stimulation of voltage-gated sodium channels (VGSCs) and the pharmacological blockade of Na+, K+-ATPase causing lysis of highly malignant cancer cells. Hypothesi
Externí odkaz:
https://doaj.org/article/40e47e30c88e4c4abff320e6a3008993
Publikováno v:
Cells, Vol 11, Iss 20, p 3240 (2022)
Voltage-gated sodium channels (VGSCs) are the target for many therapies. Variation in membrane potential occurs throughout the cell cycle, yet little attention has been devoted to the role of VGSCs and Na+,K+-ATPases. We hypothesized that in addition
Externí odkaz:
https://doaj.org/article/5310eb9c4b624574b4f2ad0010ea2b80
Autor:
Harry J. Gould, Dennis Paul
Publikováno v:
Biomedicines, Vol 10, Iss 4, p 838 (2022)
The conventional treatment of cancer has been based on the delivery of non-selective toxins and/or ionizing energy that affect both the cancer and normal tissues in the hope of destroying the offending disease before killing the patient. Unfortunatel
Externí odkaz:
https://doaj.org/article/37e2299cd9ad4e16aed2de5b72ab93f8
Autor:
Harry J. Gould, III, MD, PhD
An estimated 50 million Americans suffer from chronic pain, and an additional 25 million experience acute pain as a result of surgery or injury. Many people assume they must live with pain, but this is simply untrue. Most pain can be managed or great
Autor:
Chad K. Brady, Samantha Edenfield, Paige R. Miller, Dennis Paul, Harry J. Gould, Kelly Jean Sherman
Publikováno v:
Current Oncology, Vol 28, Iss 196, Pp 2115-2122 (2021)
Current Oncology
Current Oncology
Upregulation of voltage-gated sodium channels (VGSCs) and Na+/K+-ATPase (sodium pumps) is common across most malignant carcinomas. Targeted osmotic lysis (TOL) is a developing technology in which the concomitant stimulation of VGSCs and pharmacologic
Autor:
Harry J. Gould, Dennis Paul
Publikováno v:
Cancers. 14(19)
Life depends upon the ability of cells to evaluate and adapt to a constantly changing environment and to maintain internal stability to allow essential biochemical reactions to occur. Ions and ion channels play a crucial role in this process and are
Publikováno v:
The FASEB Journal. 36
Publikováno v:
The FASEB Journal. 36