Zobrazeno 1 - 10
of 313
pro vyhledávání: '"Harry J, Flint"'
Publikováno v:
AIMS Microbiology, Vol 10, Iss 2, Pp 311-319 (2024)
The microbial community of the human large intestine mainly ferments dietary fiber to short chain fatty acids (SCFAs), which are efficiently absorbed by the host. The three major SCFAs (acetate, propionate, and butyrate) have different fates within t
Externí odkaz:
https://doaj.org/article/16a2dd9e3d4f4873958e5e12a430f4e2
Autor:
Maria LaBouyer, Grietje Holtrop, Graham Horgan, Silvia W. Gratz, Alvaro Belenguer, Nicola Smith, Alan W. Walker, Sylvia H. Duncan, Alexandra M. Johnstone, Petra Louis, Harry J. Flint, Karen P. Scott
Publikováno v:
Gut Microbiome, Vol 3 (2022)
Metabolites produced by microbial fermentation in the human intestine, especially short-chain fatty acids (SCFAs), are known to play important roles in colonic and systemic health. Our aim here was to advance our understanding of how and why their co
Externí odkaz:
https://doaj.org/article/ca3c3b1c7ffa4cc98d83d0e78f434359
Autor:
Shui Ping Wang, Luis A. Rubio, Sylvia H. Duncan, Gillian E. Donachie, Grietje Holtrop, Galiana Lo, Freda M. Farquharson, Josef Wagner, Julian Parkhill, Petra Louis, Alan W. Walker, Harry J. Flint
Publikováno v:
mSystems, Vol 5, Iss 5 (2020)
ABSTRACT Lactate can be produced by many gut bacteria, but in adults its accumulation in the colon is often an indicator of microbiota perturbation. Using continuous culture anaerobic fermentor systems, we found that lactate concentrations remained l
Externí odkaz:
https://doaj.org/article/db6f39ae6a11410391e6b9fe0187e8e1
Autor:
Eva C. Soto-Martin, Ines Warnke, Freda M. Farquharson, Marilena Christodoulou, Graham Horgan, Muriel Derrien, Jean-Michel Faurie, Harry J. Flint, Sylvia H. Duncan, Petra Louis
Publikováno v:
mBio, Vol 11, Iss 4 (2020)
ABSTRACT We investigated the requirement of 15 human butyrate-producing gut bacterial strains for eight B vitamins and the proteinogenic amino acids by a combination of genome sequence analysis and in vitro growth experiments. The Ruminococcaceae spe
Externí odkaz:
https://doaj.org/article/ee6163f5a430469b87af383f1c5d142a
Autor:
Emmanuelle H. Crost, Gwenaelle Le Gall, Jenny A. Laverde-Gomez, Indrani Mukhopadhya, Harry J. Flint, Nathalie Juge
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
Dietary and host glycans shape the composition of the human gut microbiota with keystone carbohydrate-degrading species playing a critical role in maintaining the structure and function of gut microbial communities. Here, we focused on two major huma
Externí odkaz:
https://doaj.org/article/5f50d8f939f64ad6a8cfef37c0e6536d
Publikováno v:
Journal of The Royal Society Interface. 19
The human colon contains a dynamic microbial community whose composition has important implications for human health. In this work we build a process-based model of the colonic microbial ecosystem and compare with general empirical observations and t
Publikováno v:
Environmental Microbiology. 23:1527-1540
Type IV pili (T4P) are bacterial surface-exposed appendages that have been extensively studied in Gram-negative pathogenic bacteria. Despite recent sequencing efforts, little is known regarding these structures in non-pathogenic anaerobic Gram-positi
Autor:
Paul O. Sheridan, Petra Louis, Eleni Tsompanidou, Sophie Shaw, Hermie J. Harmsen, Sylvia H. Duncan, Harry J. Flint, Alan W. Walker
Publikováno v:
Microbial genomics, 8(1):000739. AMER SOC MICROBIOLOGY
Lactate accumulation in the human gut is linked to a range of deleterious health impacts. However, lactate is consumed and converted to the beneficial short-chain fatty acids butyrate and propionate by indigenous lactate-utilizing bacteria. To better
Autor:
Xiaolei Ze, Yonit Ben David, Jenny A. Laverde-Gomez, Bareket Dassa, Paul O. Sheridan, Sylvia H. Duncan, Petra Louis, Bernard Henrissat, Nathalie Juge, Nicole M. Koropatkin, Edward A. Bayer, Harry J. Flint
Publikováno v:
mBio, Vol 6, Iss 5 (2015)
ABSTRACT Ruminococcus bromii is a dominant member of the human gut microbiota that plays a key role in releasing energy from dietary starches that escape digestion by host enzymes via its exceptional activity against particulate “resistant” starc
Externí odkaz:
https://doaj.org/article/2a363ea495f24b07a2f9cf311e4aa5d8
Autor:
Oriana Rossi, M Tanweer Khan, Martin Schwarzer, Tomas Hudcovic, Dagmar Srutkova, Sylvia H Duncan, Ellen H Stolte, Hana Kozakova, Harry J Flint, Janneke N Samsom, Hermie J M Harmsen, Jerry M Wells
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0123013 (2015)
A decrease in the abundance and biodiversity of intestinal bacteria within the Firmicutes phylum has been associated with inflammatory bowel disease (IBD). In particular, the anti-inflammatory bacterium Faecalibacterium prausnitzii, member of the Fir
Externí odkaz:
https://doaj.org/article/416c46016e9b45f990e8cc362e750ea0