Zobrazeno 1 - 10
of 172
pro vyhledávání: '"Harry Holthöfer"'
Autor:
Om Prakash Dwivedi, Karina Barreiro, Annemari Käräjämäki, Erkka Valo, Anil K. Giri, Rashmi B. Prasad, Rishi Das Roy, Lena M. Thorn, Antti Rannikko, Harry Holthöfer, Kim M. Gooding, Steven Sourbron, Denis Delic, Maria F. Gomez, Per-Henrik Groop, Tiinamaija Tuomi, Carol Forsblom, Leif Groop, Maija Puhka
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106686- (2023)
Summary: Urinary extracellular vesicles (uEV) are a largely unexplored source of kidney-derived mRNAs with potential to serve as a liquid kidney biopsy. We assessed ∼200 uEV mRNA samples from clinical studies by genome-wide sequencing to discover m
Externí odkaz:
https://doaj.org/article/5b53c14dd8ee490b811a4f2dffd31175
Autor:
Shrey Kohli, Khurrum Shahzad, Annukka Jouppila, Harry Holthöfer, Berend Isermann, Riitta Lassila
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Hemostasis, thrombosis, and inflammation are tightly interconnected processes which may give rise to thrombo-inflammation, involved in infectious and non-infectious acute and chronic diseases, including cardiovascular diseases (CVD). Traditionally, d
Externí odkaz:
https://doaj.org/article/b61a50fdc41a4b93a12d28326398bda3
Autor:
Uta Erdbrügger, Charles J. Blijdorp, Irene V. Bijnsdorp, Francesc E. Borràs, Dylan Burger, Benedetta Bussolati, James Brian Byrd, Aled Clayton, James W. Dear, Juan M. Falcón‐Pérez, Cristina Grange, Andrew F. Hill, Harry Holthöfer, Ewout J. Hoorn, Guido Jenster, Connie R. Jimenez, Kerstin Junker, John Klein, Mark A. Knepper, Erik H. Koritzinsky, James M. Luther, Metka Lenassi, Janne Leivo, Inge Mertens, Luca Musante, Eline Oeyen, Maija Puhka, Martin E. vanRoyen, Catherine Sánchez, Carolina Soekmadji, Visith Thongboonkerd, Volkert vanSteijn, Gerald Verhaegh, Jason P. Webber, Kenneth Witwer, Peter S.T. Yuen, Lei Zheng, Alicia Llorente, Elena S. Martens‐Uzunova
Publikováno v:
Journal of Extracellular Vesicles, Vol 10, Iss 7, Pp n/a-n/a (2021)
Abstract Urine is commonly used for clinical diagnosis and biomedical research. The discovery of extracellular vesicles (EV) in urine opened a new fast‐growing scientific field. In the last decade urinary extracellular vesicles (uEVs) were shown to
Externí odkaz:
https://doaj.org/article/11056fe3164342fca660fd4db4496dcd
Autor:
Pauliina Saurus, Tuomas A. Tolvanen, Sonja Lindfors, Sara Kuusela, Harry Holthöfer, Eero Lehtonen, Sanna Lehtonen
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Lack of CD2-associated protein (CD2AP) in mice increases podocyte apoptosis and leads to glomerulosclerosis and renal failure. We showed previously that SHIP2, a negative regulator of the PI3K/AKT signalling pathway, interacts with CD2AP. He
Externí odkaz:
https://doaj.org/article/d18126741d1541cb94450899dbf983bc
Autor:
Satu Hepojoki, Lauri Kareinen, Tomas Strandin, Antti Vaheri, Harry Holthöfer, Jukka Mustonen, Satu Mäkelä, Klaus Hedman, Olli Vapalahti, Jussi Hepojoki
Publikováno v:
Viruses, Vol 11, Iss 9, p 809 (2019)
Rapid point-of-care testing is a megatrend in infectious disease diagnosis. We have introduced a homogeneous immunoassay concept, which is based on the simultaneous binding of antigen and protein L to a given immunoglobulin molecule. The complex form
Externí odkaz:
https://doaj.org/article/e6741371e8f441a3b7a8501398e339a0
Autor:
Shanying Chen, Hongmei Liu, Xinyu Liu, Yongqiang Li, Mi Li, Yan Liang, Xiaofei Shao, Harry Holthöfer, Hequn Zou
Publikováno v:
Kidney & Blood Pressure Research, Vol 37, Iss 4-5, Pp 392-401 (2013)
Objective: Previous studies have shown that central obesity is associated with chronic kidney disease (CKD). We hypothesized that the association of central obesity with CKD is modified by the presence of inflammation. To test this hypothesis, we per
Externí odkaz:
https://doaj.org/article/73410b2da26342419ba762b04e33a33b
Autor:
Yongqiang Li, Chaomin Zhou, Xiaofei Shao, Xinyu Liu, Jia Guo, Ying Zhang, Honglei Wang, Xiaohong Wang, Bin Li, Kangping Deng, Qin Liu, Harry Holthöfer, Hequn Zou
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92322 (2014)
OBJECTIVE: To examine the relationship between the HW phenotype and risk for CKD in a community population aged 40 years and older. METHODS: A cross-sectional study was conducted in Zhuhai from June to October 2012. The participants were divided into
Externí odkaz:
https://doaj.org/article/a1ae1d474f964dfcad71f9a6f26c3701
Autor:
Shanying Chen, Youming Chen, Xinyu Liu, Mi Li, Bide Wu, Yongqiang Li, Yan Liang, Xiaofei Shao, Harry Holthöfer, Hequn Zou
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74058 (2013)
OBJECTIVE: To the best of our knowledge, the association of insulin resistance (IR) with chronic kidney disease (CKD) has not been well studied in normal-weight individuals. The aim of this study is to examine whether IR is associated with CKD in non
Externí odkaz:
https://doaj.org/article/73afc74e1ccd4251a5ba84d6552b48f6
Autor:
Sandeep Kumar Vashist, Harry Holthöfer
Publikováno v:
Measurement + Control, Vol 43 (2010)
Microelectromechanical Systems (MEMS) (1–2) has come into existence only in the last decade. Microcantilevers are the most simplified MEMS based devices. Diverse applications of microcantilevers in the field of sensors have been explored by researc
Externí odkaz:
https://doaj.org/article/0e8eb55b3ec240fba93144a525257527
Autor:
Puhka, Karina Barreiro, Om Prakash Dwivedi, Antti Rannikko, Harry Holthöfer, Tiinamaija Tuomi, Per-Henrik Groop, Maija
Publikováno v:
Genes; Volume 14; Issue 7; Pages: 1415
Urinary extracellular vesicles (uEV) hold non-invasive RNA biomarkers for genitourinary tract diseases. However, missing knowledge about reference genes and effects of preanalytical choices hinder biomarker studies. We aimed to assess how preanalytic